{
  "id": 7155,
  "label": "brain glioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005499",
  "properties": {
    "xrefs": [
      "DOID:0060108",
      "GARD:0024195",
      "MEDGEN:91163",
      "NCIT:C162993",
      "SCTID:254937005",
      "UMLS:C0349661"
    ],
    "synonyms": [
      "brain malignant glioma",
      "malignant glioma of brain"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A malignant glioma that involves the brain."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 3853,
      "label": "brain cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20429
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2006-2736",
          "DOID:1319",
          "GARD:0027584",
          "ICD10CM:C71",
          "ICD9:191",
          "ICD9:191.8",
          "ICD9:191.9",
          "ICD9:239.6",
          "MEDGEN:57796",
          "MESH:D001932",
          "NCIT:C3568",
          "SCTID:428061005",
          "UMLS:C0153633",
          "icd11.foundation:189650925"
        ],
        "synonyms": [
          "brain neoplasm",
          "tumor of the brain",
          "tumour of the brain",
          "brain cancer",
          "brain neoplasms, malignant",
          "cancer of brain",
          "cancer of the brain",
          "malignant brain neoplasm",
          "malignant brain tumor",
          "malignant neoplasm of brain",
          "malignant neoplasm of the brain",
          "malignant tumor of brain",
          "malignant tumor of the brain",
          "malignant tumour of brain",
          "malignant tumour of the brain",
          "adult brain tumor",
          "adult brain tumour",
          "adult malignant brain neoplasm",
          "malignant primary brain neoplasm",
          "malignant primary brain tumor",
          "malignant primary brain tumour",
          "malignant tumor of adult brain",
          "malignant tumour of adult brain",
          "BT - brain tumor",
          "BT - brain tumour",
          "brain neoplasm, adult",
          "brain tumor, adult",
          "neoplasm of unspecified nature of brain",
          "primary brain neoplasm",
          "primary brain tumor",
          "primary brain tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the brain."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001657"
    },
    {
      "id": 24071,
      "label": "malignant glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20078,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3070",
          "GARD:0026148",
          "ICDO:9380/3",
          "MEDGEN:107826",
          "MedDRA:10018338",
          "NCIT:C4822",
          "UMLS:C0555198"
        ],
        "synonyms": [
          "glioma",
          "neuroglial tumor",
          "neuroglial tumour",
          "glial cell tumour",
          "glioma, malignant",
          "high grade glioma",
          "high-grade glioma",
          "malignant glial neoplasm",
          "malignant glial tumor",
          "malignant glial tumour",
          "malignant glioma",
          "malignant neuroglial neoplasm",
          "malignant neuroglial tumor",
          "malignant neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0100342"
    }
  ],
  "children": [
    {
      "id": 4576,
      "label": "brain glioblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7155,
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3073",
          "EFO:0006545",
          "GARD:0023150",
          "MEDGEN:138100",
          "NCIT:C4642",
          "SCTID:276828006",
          "UMLS:C0349543"
        ],
        "synonyms": [
          "brain glioblastoma",
          "brain glioblastoma (disease)",
          "brain glioblastoma multiforme",
          "brain glioblastoma multiforme (disease)",
          "glioblastoma multiforme of brain",
          "glioblastoma multiforme of the brain",
          "grade IV astrocytic tumour of brain",
          "grade IV brain astrocytic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002501"
    },
    {
      "id": 4610,
      "label": "brain oligodendroglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7155,
        17158
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3187",
          "GARD:0023160",
          "MEDGEN:91095",
          "NCIT:C9377",
          "SCTID:254940005",
          "UMLS:C0346286"
        ],
        "synonyms": [
          "brain oligodendroglioma",
          "oligodendroglioma of brain",
          "oligodendroglioma of the brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A oligodendroglioma that involves the brain."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002544"
    },
    {
      "id": 4918,
      "label": "brain stem glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4919,
        7155
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4202",
          "EFO:1000142",
          "GARD:0023297",
          "MEDGEN:195650",
          "NCIT:C8501",
          "SCTID:444545003",
          "UMLS:C0677865"
        ],
        "synonyms": [
          "brain stem glioma",
          "brain stem neuroglial neoplasm",
          "brain stem neuroglial tumor",
          "brain stem neuroglial tumour",
          "brainstem glioma",
          "brainstem malignant glioma",
          "brainstem neuroglial neoplasm",
          "brainstem neuroglial tumor",
          "brainstem neuroglial tumour",
          "diffuse brainstem glioma",
          "glioma of brain stem",
          "glioma of brainstem",
          "glioma of the brain stem",
          "glioma of the brainstem",
          "malignant glioma of brainstem"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroglial tumor that arises from the brain stem."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002911"
    },
    {
      "id": 5133,
      "label": "diencephalic astrocytomas",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4814,
        7155,
        20687
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4855",
          "GARD:0023393",
          "MEDGEN:272542",
          "NCIT:C5128",
          "UMLS:C1333284"
        ],
        "synonyms": [
          "astrocytoma (excluding glioblastoma) of diencephalon",
          "astrocytoma of diencephalon",
          "astrocytoma of the diencephalon",
          "diencephalic astrocytoma",
          "diencephalon astrocytoma",
          "diencephalon astrocytoma (excluding glioblastoma)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A astrocytoma that involves the diencephalon."
      },
      "child_count": 9,
      "reference_id": "MONDO:0003169"
    },
    {
      "id": 5909,
      "label": "childhood cerebral astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4578,
        4768,
        7155,
        8005,
        20689
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7007",
          "GARD:0009302",
          "MEDGEN:137828",
          "NCIT:C4347",
          "UMLS:C0338070"
        ],
        "synonyms": [
          "cerebral astrocytoma",
          "childhood astrocytic tumor of telencephalon",
          "childhood astrocytic tumour of telencephalon",
          "childhood astrocytoma of cerebrum",
          "childhood astrocytoma of the cerebrum",
          "paediatric astrocytoma of cerebrum",
          "paediatric astrocytoma of the cerebrum",
          "paediatric cerebral astrocytoma",
          "pediatric astrocytoma of cerebrum",
          "pediatric astrocytoma of the cerebrum",
          "pediatric cerebral astrocytoma",
          "telencephalon childhood astrocytic tumor",
          "telencephalon childhood astrocytic tumour",
          "telencephalon juvenile astrocytoma",
          "cerebral astrocytoma, childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An astrocytoma, without designation of benign or malignant, that is found in the supratentorial region. The infratentorial location is more common in children."
      },
      "child_count": 5,
      "reference_id": "MONDO:0004071"
    },
    {
      "id": 6066,
      "label": "ependymal tumor of brain",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        7155
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7497",
          "GARD:0023897",
          "MEDGEN:116038",
          "NCIT:C3861",
          "SCTID:254939008",
          "UMLS:C0238029"
        ],
        "synonyms": [
          "brain ependymal tumor",
          "brain ependymal tumour",
          "ependymal tumor of brain",
          "brain ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A tumor arising from the ependymal lining of the ventricles."
      },
      "child_count": 12,
      "reference_id": "MONDO:0004245"
    },
    {
      "id": 17147,
      "label": "gliomatosis cerebri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7155,
        17144
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6128",
          "GARD:0006514",
          "ICDO:9381/3",
          "MEDGEN:87267",
          "MedDRA:10066254",
          "NCIT:C4318",
          "Orphanet:251582",
          "UMLS:C0334576",
          "icd11.foundation:373131154"
        ],
        "synonyms": [
          "astrocytosis cerebri",
          "gliomatosis",
          "gliomatosis cerebri",
          "gliomatosis cerebri (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A diffuse glial tumor which infiltrates the brain extensively, involving more than two lobes. It is frequently bilateral and often extends to the infratentorial structures, even to the spinal cord. It is probably of astrocytic origin, although GFAP expression may be scant or absent. (Adapted from WHO.)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0016683"
    },
    {
      "id": 17167,
      "label": "chordoid glioma of the third ventricle",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4729,
        4814,
        7155,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3773",
          "DOID:3774",
          "GARD:0020715",
          "ICDO:9444/1",
          "MEDGEN:232956",
          "NCIT:C5592",
          "ONCOTREE:CHGL",
          "Orphanet:251674",
          "SCTID:715900001",
          "UMLS:C1322252"
        ],
        "synonyms": [
          "chordoid glioma",
          "chordoid glioma (morphologic abnormality)",
          "chordoid glioma of 3rd ventricle",
          "chordoid glioma of the 3rd ventricle",
          "chordoid glioma of the third ventricle",
          "chordoid glioma of the third ventricle (WHO grade II)",
          "chordoid glioma of third ventricle",
          "third ventricle chordoid glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare, slow-growing neuroepithelial neoplasm of uncertain origin affecting adults. It is located in the third ventricle. It is characterized by the presence of epithelioid cells which express GFAP, and mucinous stroma which contains lymphoplasmacytic infiltrates."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016706"
    }
  ],
  "roots": [
    {
      "id": 3853,
      "label": "brain cancer"
    },
    {
      "id": 24071,
      "label": "malignant glioma"
    }
  ]
}