{
  "id": 7181,
  "label": "toxic encephalopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005527",
  "properties": {
    "xrefs": [
      "DOID:3602",
      "EFO:0005595",
      "GARD:0007199",
      "ICD10CM:G92",
      "ICD10WHO:G92",
      "ICD9:349.82",
      "MESH:D020258",
      "NCIT:C27961",
      "SCTID:28394000",
      "Wikipedia:Toxic_encephalopathy"
    ],
    "synonyms": [
      "neurotoxicity",
      "neurotoxicity syndrome",
      "neurotoxicity syndromes"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6799,
      "label": "nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:863",
          "EFO:0000618",
          "ICD10CM:G00-G99",
          "ICD9:349.89",
          "ICD9:349.9",
          "MEDGEN:14336",
          "MESH:D009422",
          "NCIT:C26835",
          "SCTID:118940003",
          "UMLS:C0027765",
          "Wikipedia:Nervous_system_disease"
        ],
        "synonyms": [
          "disease of nervous system",
          "disease or disorder of nervous system",
          "disorder of nervous system",
          "nervous system disease",
          "nervous system disease or disorder",
          "nervous system disorder",
          "neurologic disease",
          "neurologic disorder",
          "neurological disease",
          "neurological disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005071"
    }
  ],
  "children": [
    {
      "id": 3899,
      "label": "hepatic encephalopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7181,
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13413",
          "GARD:0027587",
          "ICD9:572.2",
          "MEDGEN:5513",
          "MESH:D006501",
          "NCIT:C79596",
          "SCTID:13920009",
          "UMLS:C0019151",
          "icd11.foundation:1769383160"
        ],
        "synonyms": [
          "portal-systemic encephalopathy",
          "Hepatoencephalopathy",
          "encephalopathy, hepatic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.Signs and symptomsmay be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may includepersonality or moodchanges, intellectual impairment, abnormal movements,a depressed level of consciousness, and other symptoms.There are several theories regarding the exact cause, butdevelopment of the condition isprobablyat least partiallydue to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001711"
    },
    {
      "id": 7149,
      "label": "carbon monoxide-induced delayed encephalopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7181,
        7209,
        24962
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "delayed encephalopathy after acute carbon monoxide poisoning",
          "delayed encephalopathy in patients with acute carbon monoxide poisoning"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anoxic encephalopathy resulting from acute CO intoxication, developing within 2-6 weeks of the poisoning event"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005493"
    },
    {
      "id": 17909,
      "label": "manganese poisoning",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7181,
        21773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001808",
          "GARD:0021264",
          "ICD9:503",
          "MESH:D020149",
          "MedDRA:10058951",
          "Orphanet:306682",
          "SCTID:88687001"
        ],
        "synonyms": [
          "Manganism",
          "manganese intoxication"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include confusion; hallucinations; and an extrapyramidal syndrome (Parkinson disease, secondary) that includes rigidity; dystonia; retropulsion; and tremor. (Adams, Principles of Neurology, 6th ed, p1213)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0017638"
    },
    {
      "id": 21301,
      "label": "Minamata disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7181
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027913",
          "MEDGEN:43368",
          "SCTID:39640004",
          "UMLS:C0086626"
        ],
        "synonyms": [
          "Chisso-Minamata disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neurological syndrome caused by severe mercury poisoning."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024251"
    },
    {
      "id": 22825,
      "label": "chronic bilirubin encephalopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7181,
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022198",
          "MEDGEN:1806573",
          "Orphanet:529808",
          "UMLS:C5575229"
        ],
        "synonyms": [
          "BIND",
          "Bilirubin-induced neurological dysfunction",
          "CBE",
          "KSD",
          "Kernicterus spectrum disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare neurologic disease characterized by the chronic consequences of bilirubin toxicity in the globus pallidus, sub-thalamic nuclei, and other brain regions, after exposure to high levels of unconjugated bilirubin in the neonatal period. Symptoms begin after the acute phase of bilirubin encephalopathy in the first year of life, evolve slowly over several years, and include mild to severe extrapyramidal disturbances (especially dystonia and athetosis), auditory neuropathy spectrum disorder, and oculomotor and dental abnormalities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0035345"
    }
  ],
  "roots": [
    {
      "id": 6799,
      "label": "nervous system disorder"
    }
  ]
}