{
  "id": 7199,
  "label": "renal cell adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005549",
  "properties": {
    "xrefs": [
      "EFO:0005708",
      "GARD:0024205",
      "ICDO:8311/1",
      "ICDO:8312/3",
      "NANDO:2200045",
      "NCIT:C9385"
    ],
    "synonyms": [
      "renal cell carcinoma",
      "RCC",
      "adenocarcinoma of kidney",
      "adenocarcinoma of the kidney",
      "carcinoma, renal cell, malignant",
      "kidney adenocarcinoma",
      "renal cell adenocarcinoma",
      "renal cell cancer",
      "renal cell carcinoma, stage unspecified"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A carcinoma arising from the renal parenchyma. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6814,
      "label": "renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6923
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4450",
          "EFO:0000681",
          "GARD:0013215",
          "HP:0005584",
          "ICD9:189.0",
          "MEDGEN:766",
          "MESH:D002292",
          "MedDRA:10067946",
          "NANDO:2200045",
          "NORD:1657",
          "ONCOTREE:RCC",
          "Orphanet:217071",
          "SCTID:702391001",
          "UMLS:C0007134"
        ],
        "synonyms": [
          "RCC",
          "renal cell carcinoma",
          "renal cell carcinoma (disease)",
          "kidney adenocarcinoma",
          "renal cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the kidney"
      },
      "child_count": 22,
      "reference_id": "MONDO:0005086"
    }
  ],
  "children": [
    {
      "id": 5005,
      "label": "childhood kidney cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7199,
        22942
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4454",
          "GARD:0023325",
          "MEDGEN:232070",
          "NCIT:C6568",
          "UMLS:C1333001"
        ],
        "synonyms": [
          "renal cell cancer",
          "childhood kidney cell carcinoma",
          "childhood renal cell carcinoma",
          "childhood renal cell carcinoma (disease)",
          "paediatric kidney cell carcinoma",
          "paediatric renal cell carcinoma",
          "paediatric renal cell carcinoma (disease)",
          "pediatric kidney cell carcinoma",
          "pediatric renal cell carcinoma",
          "pediatric renal cell carcinoma (disease)",
          "renal cell carcinoma (disease) of childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A renal cell carcinoma that occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003007"
    },
    {
      "id": 5006,
      "label": "hereditary renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7199,
        23932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4455",
          "GARD:0023326",
          "MEDGEN:392857",
          "MESH:C536851",
          "NCIT:C39789",
          "SCTID:717736007",
          "UMLS:C2608055"
        ],
        "synonyms": [
          "hereditary renal cell cancer",
          "hereditary renal cell carcinoma",
          "hereditary renal cell carcinoma (disease)",
          "familial renal carcinoma",
          "hereditary renal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "An instance of renal cell carcinoma (disease) that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 14,
      "reference_id": "MONDO:0003008"
    },
    {
      "id": 5010,
      "label": "sarcomatoid renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7199,
        7925
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4473",
          "GARD:0023327",
          "ICDO:8318/3",
          "MEDGEN:220411",
          "NCIT:C27893",
          "ONCOTREE:SRCC",
          "UMLS:C1266043"
        ],
        "synonyms": [
          "RCC w/ sarcomatoid features",
          "renal cell carcinoma with sarcomatoid features",
          "sarcomatoid renal cell cancer",
          "sarcomatoid renal cell carcinoma",
          "SRCC"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A high grade carcinoma of the kidney. It is not a distinct clinicopathological entity and includes a diverse group of renal cell carcinomas which have been transformed from a lower to a higher grade."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003012"
    },
    {
      "id": 6743,
      "label": "clear cell renal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6742,
        7199,
        9112
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4467",
          "EFO:0000349",
          "GARD:0009574",
          "ICD9:189.0",
          "MEDGEN:76018",
          "NCIT:C4033",
          "ONCOTREE:CCRCC",
          "Orphanet:319276",
          "SCTID:254915003",
          "UMLS:C0279702"
        ],
        "synonyms": [
          "Grawitz tumor",
          "Grawitz tumour",
          "RCC, clear cell adenocarcinoma",
          "clear cell adenocarcinoma of kidney",
          "clear cell adenocarcinoma of the kidney",
          "clear cell adenocarcinoma, kidney",
          "clear cell carcinoma of kidney",
          "clear cell carcinoma of the kidney",
          "clear cell renal cell cancer",
          "clear cell renal cell carcinoma",
          "conventional (clear cell) renal cell adenocarcinoma",
          "conventional (clear cell) renal cell carcinoma",
          "conventional renal cell carcinoma",
          "kidney clear cell adenocarcinoma",
          "kidney clear cell carcinoma",
          "renal cell carcinoma, clear cell adenocarcinoma",
          "renal clear cell adenocarcinoma",
          "renal clear cell carcinoma",
          "clear-cell metastatic renal cell carcinoma",
          "hypernephroma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005005"
    },
    {
      "id": 7917,
      "label": "renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081415",
          "EFO:1000508",
          "GARD:0024396",
          "ICDO:0000/0",
          "MEDGEN:235005",
          "NCIT:C27891",
          "ONCOTREE:TRCC",
          "UMLS:C1337036"
        ],
        "synonyms": [
          "TFE3-Rearranged renal cell carcinoma",
          "Xp11.2 translocation-related renal cell carcinoma",
          "renal cell cancer associated with Xp11.2 translocations/TFE3 Gene fusions",
          "renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions",
          "tRCC",
          "translocation-associated renal cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A group of kidney carcinomas characterized by the presence of different translocations involving the chromosome Xp11.2. These translocations result in the creation of gene fusions involving the TFE3 gene. Patients are usually children and young adults. Morphologically, the malignant epithelial cells form papillary patterns."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006397"
    },
    {
      "id": 18097,
      "label": "papillary renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        7199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4465",
          "EFO:0000640",
          "GARD:0009572",
          "MEDGEN:266300",
          "NCIT:C6975",
          "ONCOTREE:PRCC",
          "Orphanet:319298",
          "SCTID:733608000",
          "UMLS:C1306837"
        ],
        "synonyms": [
          "HPRCC",
          "chromophil carcinoma of kidney",
          "chromophil carcinoma of the kidney",
          "chromophil renal cell carcinoma",
          "papillary (chromophil) renal cell carcinoma",
          "papillary renal cell adenocarcinoma",
          "papillary renal cell cancer",
          "papillary renal cell carcinoma",
          "renal cell carcinoma, papillary, type 1",
          "RCCP",
          "RCCP1",
          "chromophil RCC",
          "papillary renal carcinoma, malignant - (subtype)",
          "papillary renal cell carcinoma, bilateral - (subtype)",
          "papillary renal cell carcinoma, familial - (subtype)",
          "papillary renal cell carcinoma, multiple - (subtype)",
          "papillary renal cell carcinoma, sporadic - (subtype)",
          "renal adenocarcinoma",
          "renal cell carcinoma, papillary, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare subtype of renal cell carcinoma, arising from the renal tubular epithelium and showing a papillary growth pattern, which typically manifests with hematuria, flank pain, palpable abdominal mass or nonspecific symptoms, such as fatigue, weight loss or fever. Symptoms related to metastatic spread, such as bone pain or persistent cough, are frequently associated since early diagnosis is not common. It is typically multifocal, bilateral, and in most cases sporadic, although different hereditary syndromes, such as Hereditary leiomyoma renal cell carcinoma, Birt-Hogg-DubC) syndrome and Tuberous sclerosis, may predispose to the development of papillary renal cell carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017884"
    },
    {
      "id": 18098,
      "label": "chromophobe renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4471",
          "EFO:0000335",
          "GARD:0006064",
          "ICDO:8270/3",
          "ICDO:8317/3",
          "MEDGEN:266091",
          "NCIT:C4146",
          "ONCOTREE:CHRCC",
          "Orphanet:319303",
          "SCTID:733471003",
          "UMLS:C1266042"
        ],
        "synonyms": [
          "chromophobe adenocarcinoma",
          "chromophobe carcinoma",
          "chromophobe carcinoma of kidney",
          "chromophobe carcinoma of the kidney",
          "chromophobe cell carcinoma of kidney",
          "chromophobe cell carcinoma of the kidney",
          "chromophobe renal cell adenocarcinoma",
          "chromophobe renal cell cancer",
          "chromophobe renal cell carcinoma",
          "renal cell carcinoma, chromophobe type",
          "CHRCC",
          "CRCC",
          "ChRCC"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Chromophobe renal cell carcinoma is a rare subtype of renal cell carcinoma, originating from the intercalating cells of the collecting ducts and macroscopically manifesting as a well-circumscribed, highly lobulated, solid tumor that is usually diagnosed at an early stage. It is frequently asymptomatic, or may present with nonspecific symptoms, such as weight loss, fever or fatigue. The classic presentation observed in renal tumors (hematuria, flank pain and palpable mass) is occasionally observed and usually indicates an advanced stage of the disease. It is most frequently sporadic however, several familial cases, associated with Birt-Hogg DubC) syndrome, have been described."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017885"
    },
    {
      "id": 18100,
      "label": "renal cell carcinoma associated with neuroblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025123",
          "MEDGEN:473928",
          "NCIT:C100051",
          "Orphanet:319314",
          "UMLS:C3272295"
        ],
        "synonyms": [
          "renal cell cancer associated with neuroblastoma",
          "renal cell carcinoma after neuroblastoma",
          "renal cell carcinoma associated with neuroblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Renal cell carcinoma that develops in patients who are long-term survivors of childhood neuroblastoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017887"
    },
    {
      "id": 18101,
      "label": "tubulocystic renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021419",
          "MEDGEN:925623",
          "NCIT:C126303",
          "Orphanet:319325",
          "SCTID:733603009",
          "UMLS:C4288091"
        ],
        "synonyms": [
          "Tubulocystic renal cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Tubulocystic renal cell carcinoma is an extremely rare subtype of renal cell carcinoma most frequently characterized by a small, solitary, well-circumscribed, unencapsulated renal tumor composed of multiple small to medium-sized cysts with a white or gray, spongy (\"bubble wrap-like\") cut surface. Patients are usually asymptomatic or could manifest with abdominal pain, abdominal distension and/or hematuria. Progression, recurrence and metastasis rarely occur although lymph node, bone, pleura and liver mestatsis have been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017890"
    }
  ],
  "roots": [
    {
      "id": 6814,
      "label": "renal cell carcinoma"
    }
  ]
}