{
  "id": 7207,
  "label": "ovarian disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005558",
  "properties": {
    "xrefs": [
      "DOID:1100",
      "EFO:0005771",
      "MEDGEN:892314",
      "MESH:D010049",
      "NCIT:C26841",
      "SCTID:5552004",
      "UMLS:C4021818"
    ],
    "synonyms": [
      "disease of ovary",
      "disease or disorder of ovary",
      "disorder of ovary",
      "ovarian disease",
      "ovarian disorder",
      "ovary disease",
      "ovary disease or disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A disease involving the ovary."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 4375,
      "label": "gonadal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2277",
          "MEDGEN:9074",
          "MESH:D006058",
          "NCIT:C26786",
          "UMLS:C0018050"
        ],
        "synonyms": [
          "disease of gonad",
          "disease or disorder of gonad",
          "disorder of gonad",
          "disorder of gonads",
          "gonad disease",
          "gonad disease or disorder",
          "gonadal disorder",
          "gonadal disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the testis or the ovary."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002259"
    },
    {
      "id": 4379,
      "label": "female reproductive system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:229",
          "EFO:0009549",
          "ICD9:629.9",
          "MEDGEN:65928",
          "MESH:D005831",
          "NCIT:C27020",
          "SCTID:310789003",
          "UMLS:C0236100"
        ],
        "synonyms": [
          "disease of female reproductive system",
          "disease or disorder of female reproductive system",
          "disorder of female genital system",
          "disorder of female reproductive system",
          "female reproductive disease",
          "female reproductive system disease",
          "female reproductive system disease or disorder",
          "female reproductive system disorder",
          "disease of female genital system",
          "disorder of female genital tract",
          "gynaecological disease",
          "gynecological disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A disease involving the female reproductive system."
      },
      "child_count": 34,
      "reference_id": "MONDO:0002263"
    }
  ],
  "children": [
    {
      "id": 4064,
      "label": "ovarian dysfunction",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1414",
          "EFO:0009003",
          "ICD10CM:E28",
          "ICD10WHO:E28",
          "ICD9:256.3",
          "ICD9:256.39",
          "ICD9:256.8",
          "ICD9:256.9",
          "MEDGEN:509544",
          "NCIT:C113351",
          "SCTID:37102008",
          "UMLS:C0154208",
          "icd11.foundation:1801368748"
        ],
        "synonyms": [
          "ovarian failure",
          "ovarian hypofunction",
          "ovarian insufficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "The inability of the ovaries to function."
      },
      "child_count": 1,
      "reference_id": "MONDO:0001889"
    },
    {
      "id": 4806,
      "label": "anovulation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3781",
          "MEDGEN:1951",
          "MESH:D000858",
          "UMLS:C0003128",
          "icd11.foundation:563648258"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "The absence of ovulation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002775"
    },
    {
      "id": 5223,
      "label": "ovarian cyst",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5119",
          "HP:0000138",
          "ICD9:620.2",
          "MEDGEN:14540",
          "MESH:D010048",
          "SCTID:79883001",
          "UMLS:C0029927"
        ],
        "synonyms": [
          "ovarian cyst",
          "ovarian cyst (disease)",
          "corpus luteum cyst",
          "corpus luteum cysts",
          "cyst, corpus luteum",
          "cyst, ovarian",
          "cysts, corpus luteum",
          "cysts, ovarian"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0003282"
    },
    {
      "id": 6016,
      "label": "ovarian stromal hyperthecosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7347",
          "MEDGEN:309519",
          "NCIT:C40446",
          "UMLS:C1518743"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-neoplastic disorder that usually affects postmenopausal women. It is characterized by the leuteinization of ovarian stromal cells. The ovaries are bilaterally involved and enlarged. When it affects women in reproductive age, it causes virilization, high blood pressure, and increased insulin levels."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004194"
    },
    {
      "id": 6200,
      "label": "luteoma of pregnancy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7207,
        21520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7880",
          "MEDGEN:137726",
          "MESH:D018311",
          "NCIT:C40445",
          "UMLS:C0334209"
        ],
        "synonyms": [
          "leuteoma of pregnancy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-neoplastic and self-limited condition that occurs during pregnancy. It is characterized by proliferation of luteinized stromal cells that replace the normal ovarian stromal cells. It is usually manifested with bilateral multinodular ovarian masses. Treatment is not required."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004387"
    },
    {
      "id": 7866,
      "label": "ovarian endometriosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6857,
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11432",
          "EFO:1000418",
          "ICD10CM:N80.1",
          "ICD9:617.1",
          "MEDGEN:102350",
          "NCIT:C27628",
          "SCTID:266589005",
          "UMLS:C0156344"
        ],
        "synonyms": [
          "endometriosis (disease) of ovary",
          "endometriosis of ovary",
          "ovarian endometriosis",
          "ovary endometriosis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-neoplastic disorder characterized by the growth of endometrial tissue in the ovaries. It results in the development of blood filled ovarian cysts (chocolate cysts), and creation of scars and adhesions."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006337"
    },
    {
      "id": 8316,
      "label": "oophoritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7207,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10974",
          "EFO:1001071",
          "MEDGEN:14486",
          "MESH:D009869",
          "MedDRA:10030345",
          "SCTID:76047005",
          "UMLS:C0029051"
        ],
        "synonyms": [
          "inflammation of ovary",
          "ovary inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Inflammation of the ovary, generally caused by an ascending infection of organisms from the endocervix."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006877"
    },
    {
      "id": 13043,
      "label": "ovarian hyperstimulation syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5425",
          "GARD:0016668",
          "ICD9:256.1",
          "MEDGEN:38966",
          "MESH:D016471",
          "MedDRA:10033266",
          "OMIM:608115",
          "Orphanet:64739",
          "SCTID:129635004",
          "UMLS:C0085083",
          "icd11.foundation:1216664013"
        ],
        "synonyms": [
          "OHSS",
          "ovarian hyperstimulation syndrome",
          "ovarian hyperstimulation syndrome, familial gestational spontaneous"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A complication of ovulation induction in infertility treatment. It is graded by the severity of symptoms which include ovary enlargement, multiple ovarian follicles; ovarian cysts; ascites; and generalized edema. The full-blown syndrome may lead to renal failure, respiratory distress, and even death. Increased capillary permeability is caused by the vasoactive substances, such as vascular endothelial growth factors, secreted by the overly-stimulated ovaries."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011972"
    },
    {
      "id": 20309,
      "label": "ovarian neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7207,
        20384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003893",
          "ICD9:239.5",
          "MEDGEN:181539",
          "NCIT:C4984",
          "SCTID:123843001",
          "UMLS:C0919267"
        ],
        "synonyms": [
          "neoplasm of ovary",
          "neoplasm of the ovary",
          "ovarian neoplasm",
          "ovarian tumor",
          "ovarian tumors",
          "ovarian tumour",
          "ovarian tumours",
          "ovary neoplasm",
          "ovary neoplasm (disease)",
          "ovary tumor",
          "ovary tumour",
          "tumor of ovary",
          "tumor of the ovary",
          "tumour of ovary",
          "tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant neoplasm involving the ovary."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021068"
    },
    {
      "id": 21722,
      "label": "ovarian remnant syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1856973",
          "UMLS:C5886744",
          "icd11.foundation:584962583"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Ovarian remnant syndrome (ORS) is characterized by the presence of residual ovarian tissue after a woman has had surgery to remove one ovary or both ovaries (oophorectomy). Signs and symptoms may include pelvic pain, a pelvic mass, or the absence of menopause after oophorectomy. The condition may be caused by surgical factors leading to incomplete removal of ovarian tissue, including factors that limit surgical exposure of the ovary or compromise surgical technique. Factors may include pelvic adhesions (limiting ability to see the ovary or causing it to adhere to other tissues); anatomic variations; bleeding during surgery; or poor surgical technique. Treatment is indicated for people with symptoms and typically involves surgery to remove the residual tissue. Therapy for those who refuse surgery, cannot have surgery, or do not have a pelvic mass may include hormonal therapy to suppress ovarian function."
      },
      "child_count": 0,
      "reference_id": "MONDO:0025956"
    },
    {
      "id": 23282,
      "label": "ovarian ectopic pregnancy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3124,
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:46073",
          "MESH:D065172",
          "NCIT:C92945",
          "SCTID:9899009",
          "UMLS:C0032991"
        ],
        "synonyms": [
          "ectopic pregnancy of ovary",
          "ovarian pregnancy",
          "ovary ectopic pregnancy",
          "Pregnancies, ovarian",
          "ovarian Pregnancies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An abnormal pregnancy in which the conception is implanted on the ovary."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044098"
    }
  ],
  "roots": [
    {
      "id": 4375,
      "label": "gonadal disorder"
    },
    {
      "id": 4379,
      "label": "female reproductive system disorder"
    }
  ]
}