{
  "id": 7210,
  "label": "aortic disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005561",
  "properties": {
    "xrefs": [
      "DOID:520",
      "EFO:0005775",
      "ICD9:447.9",
      "MEDGEN:1618",
      "MESH:D001018",
      "NCIT:C101253",
      "SCTID:47040006",
      "UMLS:C0003493"
    ],
    "synonyms": [
      "aorta disease",
      "aorta disease or disorder",
      "disease of aorta",
      "disease or disorder of aorta",
      "disorder of aorta"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Pathology involving the thoracic, thoracoabdominal, or abdominal aorta (including aneurysms). (ACC)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 17,
  "parents": [
    {
      "id": 2933,
      "label": "arterial disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050828",
          "ICD9:447.8",
          "ICD9:447.9",
          "MEDGEN:208875",
          "NCIT:C35317",
          "SCTID:359557001",
          "UMLS:C0852949"
        ],
        "synonyms": [
          "arterial disease",
          "arterial disorder",
          "arteriopathy",
          "artery disease",
          "artery disease or disorder",
          "disease of artery",
          "disease or disorder of artery",
          "disorder of artery"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An impairment of the structure or function of the blood vessels which carry blood away from the heart."
      },
      "child_count": 30,
      "reference_id": "MONDO:0000473"
    }
  ],
  "children": [
    {
      "id": 3249,
      "label": "aortic atherosclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7003,
        7210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10230",
          "HP:0012397",
          "ICD10CM:I70.0",
          "ICD9:440.0",
          "MEDGEN:510061",
          "SCTID:81817003",
          "UMLS:C0155733",
          "icd11.foundation:1600740300"
        ],
        "synonyms": [
          "aorta atherosclerosis",
          "aortic atherosclerosis",
          "aortic atherosclerosis (disease)",
          "atherosclerosis of aorta"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A atherosclerosis that involves the aorta."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000980"
    },
    {
      "id": 4040,
      "label": "aorta atresia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14037",
          "ICD10CM:Q25.2",
          "ICD9:747.22",
          "MEDGEN:576689",
          "SCTID:204431007",
          "UMLS:C0345010"
        ],
        "synonyms": [
          "congenital atresia and stenosis of aorta"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An aortic disease that is characterized by an absence of an opening from the left ventricle of the heart into the aorta."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001863"
    },
    {
      "id": 4399,
      "label": "renal artery disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6948,
        7210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2388",
          "ICD9:593.81",
          "MEDGEN:768693",
          "NCIT:C101254",
          "SCTID:16934004",
          "UMLS:C3640053"
        ],
        "synonyms": [
          "vascular disorder of kidney"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease involving the renal artery."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002286"
    },
    {
      "id": 4733,
      "label": "superior mesenteric artery syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        4734,
        7210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3557",
          "GARD:0007712",
          "MEDGEN:21404",
          "MESH:D013478",
          "NCIT:C85175",
          "NORD:1955",
          "Orphanet:622099",
          "SCTID:197006009",
          "UMLS:C0038828"
        ],
        "synonyms": [
          "superior mesenteric artery syndrome",
          "superior mesenteric artery syndromic disease",
          "syndromic disease of superior mesenteric artery",
          "Arteriomesenteric duodenal compression syndrome",
          "Cast syndrome",
          "Wilkie syndrome",
          "vascular compression of the duodenum"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Superior mesenteric artery syndrome (SMAS) is a digestive condition that occurs when the duodenum (the first part of the small intestine) is compressed between two arteries (the aorta and the superior mesenteric artery). This compression causes partial or complete blockage of the duodenum. Symptoms vary based on severity, but can be severely debilitating. Symptoms may include abdominal pain, fullness, nausea, vomiting, and/or weight loss. SMAS typically is due toloss of the mesenteric fat pad (fatty tissue that surrounds the superior mesenteric artery). The most common cause is significant weight loss caused by medical disorders, psychological disorders, or surgery. In younger patients, it most commonly occurs after corrective spinal surgery for scoliosis. Delays in diagnosis may result in significant complications. Depending on the cause and severity, treatment options may include addressing the underlying cause, dietary changes (small feedings or a liquid diet), and/or surgery. Symptoms may not resolve completely after treatment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002687"
    },
    {
      "id": 5678,
      "label": "aortic valve disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4883,
        7210,
        23501
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:62",
          "EFO:0009531",
          "ICD9:395",
          "ICD9:424.1",
          "MEDGEN:226776",
          "NCIT:C78650",
          "UMLS:C1260873",
          "icd11.foundation:1609206873"
        ],
        "synonyms": [
          "aortic valve disease",
          "aortic valve disease or disorder",
          "aortic valve disorder",
          "disease of aortic valve",
          "disease or disorder of aortic valve",
          "disorder of aortic valve"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease involving the aortic valve."
      },
      "child_count": 15,
      "reference_id": "MONDO:0003803"
    },
    {
      "id": 6338,
      "label": "aortic malignant tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7210,
        23003
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8352",
          "MEDGEN:235290",
          "NCIT:C5375",
          "UMLS:C1334560"
        ],
        "synonyms": [
          "aorta cancer",
          "aortic malignant neoplasm",
          "cancer of aorta",
          "malignant aorta neoplasm",
          "malignant aortic neoplasm",
          "malignant neoplasm of aorta",
          "malignant neoplasm of the aorta",
          "malignant tumor of aorta",
          "malignant tumor of the aorta",
          "malignant tumour of aorta",
          "malignant tumour of the aorta"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A cancer that involves the aorta."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004539"
    },
    {
      "id": 6883,
      "label": "aortic aneurysm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3627",
          "EFO:0001666",
          "HP:0004942",
          "ICD9:441.1",
          "ICD9:441.3",
          "ICD9:441.5",
          "ICD9:441.6",
          "MEDGEN:362",
          "MESH:D001014",
          "NANDO:2100101",
          "NANDO:2200294",
          "SCTID:73067008",
          "UMLS:C0003486"
        ],
        "synonyms": [
          "abdominal aortic aneurysm, ruptured",
          "aortic aneurysm",
          "aortic aneurysm (disease)",
          "aortic aneurysm of unspecified site, ruptured",
          "ruptured abdominal aortic aneurysm",
          "ruptured thoracic aneurysm",
          "ruptured thoracic aortic aneurysm",
          "ruptured thoracoabdominal aortic aneurysm",
          "thoracic aortic aneurysm which HAS ruptured",
          "thoracic aortic aneurysm, ruptured",
          "thoracoabdominal aortic aneurysm, ruptured"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A ruptured aneurysm located in the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005160"
    },
    {
      "id": 7588,
      "label": "tricuspid valve stenosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2932,
        7210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4078",
          "EFO:0007525",
          "HP:0010446",
          "MEDGEN:21678",
          "MESH:D014264",
          "NANDO:2200300",
          "NCIT:C50783",
          "SCTID:49915006",
          "UMLS:C0040963",
          "icd11.foundation:442626161"
        ],
        "synonyms": [
          "tricuspid stenosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Narrowing or stricture of the tricuspid orifice of the heart."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005997"
    },
    {
      "id": 8128,
      "label": "aortitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:519",
          "EFO:1000816",
          "GARD:0024455",
          "MEDGEN:8154",
          "MESH:D001025",
          "MedDRA:10002921",
          "NANDO:1200251",
          "NANDO:2200423",
          "NCIT:C97085",
          "SCTID:70933002",
          "UMLS:C0003509"
        ],
        "synonyms": [
          "aorta inflammation",
          "inflammation of aorta"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Inflammation of the aorta. Causes include trauma, infectious disorders, and connective tissue disorders."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006656"
    },
    {
      "id": 8424,
      "label": "tricuspid valve prolapse",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210,
        19774
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5644",
          "EFO:1001218",
          "HP:0001704",
          "MEDGEN:11912",
          "MESH:D014263",
          "MedDRA:10066862",
          "Orphanet:95458",
          "SCTID:253383003",
          "UMLS:C0040962",
          "icd11.foundation:973833808"
        ],
        "synonyms": [
          "tricuspid valve prolapse",
          "tricuspid valve prolapse (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Abnormal protrusion of one or more of the leaflets of tricuspid valve into the right atrium during systole. This allows the backflow of blood into right atrium leading to tricuspid valve insufficiency; systolic murmurs. Its most common cause is not primary valve abnormality but rather the dilation of the right ventricle and the tricuspid annulus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007001"
    },
    {
      "id": 8740,
      "label": "aorta coarctation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7210,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0051054",
          "EFO:1001267",
          "GARD:0005828",
          "ICD10CM:Q25.1",
          "ICD9:747.10",
          "MEDGEN:1617",
          "MESH:D001017",
          "MedDRA:10009807",
          "NANDO:2200283",
          "NANDO:2200284",
          "NCIT:C84567",
          "OMIM:120000",
          "Orphanet:1457",
          "SCTID:7305005",
          "UMLS:C0003492",
          "icd11.foundation:1524185114"
        ],
        "synonyms": [
          "aortic coarctation",
          "coarctation of aorta",
          "coarctation of the aorta"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Congenital narrowing of a segment of the aorta. Signs and symptoms include hypertension, muscle weakness, shortness of breath, headaches and leg cramps."
      },
      "child_count": 6,
      "reference_id": "MONDO:0007345"
    },
    {
      "id": 11269,
      "label": "subaortic stenosis, membranous",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        7210,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018242",
          "MEDGEN:336468",
          "MESH:C564793",
          "OMIM:271950",
          "UMLS:C1848979"
        ],
        "synonyms": [
          "subaortic stenosis, membranous"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010081"
    },
    {
      "id": 16109,
      "label": "aneurysm of sinus of Valsalva",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000670",
          "ICD9:747.29",
          "MEDGEN:853730",
          "NANDO:2200293",
          "Orphanet:1054",
          "SCTID:54160000",
          "UMLS:C2239253",
          "icd11.foundation:364348641"
        ],
        "synonyms": [
          "SVA",
          "sinus of Valsalva aneurysm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Sinus of Valsalva aneurysm (SVA) is a rare congenital heart malformation of one or more of the aortic sinuses, consisting of a dilation that when unruptured is usually asymptomatic but when ruptured presents with progressive exertional dyspnea, fatigue, chest pain and that can lead to congestive heart failure if left untreated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015197"
    },
    {
      "id": 20544,
      "label": "neoplasm of aortic body",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210,
        20295,
        20321,
        20518,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025316",
          "ICD9:239.7",
          "ICDO:8691/1",
          "MEDGEN:87236",
          "NCIT:C4218",
          "SCTID:127029006",
          "UMLS:C0334417"
        ],
        "synonyms": [
          "aortic body neoplasm",
          "aortic body neoplasm (disease)",
          "aortic body paraganglioma",
          "aortic body tumor",
          "aortic body tumour",
          "aorticopulmonary paraganglioma",
          "neoplasm of aortic body",
          "neoplasm of the aortic body",
          "paraganglioma of aortic body",
          "paraganglioma of the aortic body",
          "tumor of aortic body",
          "tumor of the aortic body",
          "tumour of aortic body",
          "tumour of the aortic body"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant extra-adrenal parasympathetic paraganglioma that arises from paraganglia adjacent to the base of the heart and great vessels."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021389"
    },
    {
      "id": 23235,
      "label": "Leriche syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        7210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:44114",
          "MESH:D007925",
          "NCIT:C34773",
          "SCTID:307816004",
          "UMLS:C0023370"
        ],
        "synonyms": [
          "Leriche syndrome",
          "leriche's syndrome",
          "Leriche's syndrome",
          "Leriches syndrome",
          "syndrome, Leriche",
          "syndrome, Leriche's"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An atherosclerotic disorder of the peripheral vascular system affecting mostly males in their later decades. It is caused by thrombotic occlusion of the abdominal aorta just above the level of the bifurcation. Clinical signs include impotence, intermittent claudication, diminished femoral pulses and cold, pallid lower extremities. Prognosis is favorable with surgical or endovascular intervention."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043683"
    },
    {
      "id": 25133,
      "label": "X-linked severe syndromic thoracic aortic aneurysm and dissection",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022490",
          "Orphanet:622925"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850095"
    },
    {
      "id": 26411,
      "label": "fibromuscular dysplasia of the renal arteries",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210,
        8215
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:698043"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0980998"
    }
  ],
  "roots": [
    {
      "id": 2933,
      "label": "arterial disorder"
    }
  ]
}