{
  "id": 7211,
  "label": "nut midline carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005563",
  "properties": {
    "xrefs": [
      "DOID:0060463",
      "EFO:0005783",
      "GARD:0021852",
      "MEDGEN:312999",
      "NCIT:C45716",
      "ONCOTREE:NMCHN",
      "Orphanet:443167",
      "UMLS:C1707291",
      "Wikipedia:NUT_midline_carcinoma"
    ],
    "synonyms": [
      "Midline carcinoma of children and Young adults with NUT rearrangement",
      "NMC",
      "NUT Midline carcinoma",
      "NUT carcinoma",
      "carcinoma with t(15;19)(q13;p13.1) translocation",
      "nuclear protein in testis midline carcinoma",
      "NUT midline carcinoma of the head and neck"
    ],
    "definition": "A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly the head, neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) is present that results in the creation of a fusion gene involving the NUT gene, most commonly BRD4-NUT fusion gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7257,
      "label": "undifferentiated carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006772",
          "ICDO:8020/3",
          "ICDO:8021/3",
          "MEDGEN:60010",
          "NCIT:C3692",
          "UMLS:C0205698"
        ],
        "synonyms": [
          "anaplastic carcinoma",
          "carcinoma, undifferentiated",
          "carcinoma, undifferentiated, malignant",
          "undifferentiated carcinoma"
        ],
        "definition": "A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or transitional cell differentiation."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005617"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7257,
      "label": "undifferentiated carcinoma"
    }
  ]
}