{
  "id": 7215,
  "label": "substance withdrawal syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005567",
  "properties": {
    "xrefs": [
      "DOID:0060001",
      "EFO:0005800",
      "ICD9:292.0",
      "MEDGEN:20990",
      "MESH:D013375",
      "NCIT:C35046",
      "SCTID:363101005",
      "UMLS:C0038587"
    ],
    "synonyms": [
      "drug withdrawal",
      "drug withdrawal syndrome",
      "substance withdrawal",
      "substance withdrawal disorder",
      "substance withdrawal syndrome",
      "withdrawal syndrome",
      "withdrawal disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "A substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of a substance (including alcohol, prescribed medications and recreational drugs). Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 4573,
      "label": "substance-related disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4172
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:303",
          "ICD10CM:F10-F19",
          "MEDGEN:66746",
          "MESH:D019966",
          "NCIT:C92203",
          "UMLS:C0236969"
        ],
        "synonyms": [
          "substance induced mood disorders",
          "substance-related disorder"
        ],
        "definition": "A category of psychiatric disorders which include disorders related to the taking of a drug of abuse (including alcohol, prescribed medications and recreational drugs)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002494"
    }
  ],
  "children": [
    {
      "id": 7100,
      "label": "alcohol withdrawal",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7215
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004777",
          "ICD9:291.81",
          "MEDGEN:536543",
          "SCTID:191480000",
          "UMLS:C0236663",
          "icd11.foundation:998231424"
        ],
        "synonyms": [
          "alcohol withdrawal syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0005433"
    },
    {
      "id": 7214,
      "label": "neonatal abstinence syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7215
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9828",
          "EFO:0005799",
          "ICD10CM:P96.1",
          "ICD9:760.8",
          "ICD9:779.5",
          "MEDGEN:10207",
          "MESH:D009357",
          "NCIT:C87101",
          "SCTID:414819007",
          "UMLS:C0027609"
        ],
        "synonyms": [
          "NAS",
          "neonatal narcotic withdrawal syndrome",
          "neonatal withdrawal"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005566"
    },
    {
      "id": 24442,
      "label": "baclofen withdrawal syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7215
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Withdrawal syndrome involving the abrupt discontinuation of baclofen therapy (intrathecal or oral). Baclofen withdrawal syndrome can result in high fever, altered mental status (including agitation, insomnia, confusion, delusions, hallucinations, seizures, visual changes, or psychosis), and potentially profound muscular rigidity that sometimes progresses to fatal rhabdomyolysis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700046"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 4573,
      "label": "substance-related disorder"
    }
  ]
}