{
  "id": 7220,
  "label": "tauopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005574",
  "properties": {
    "xrefs": [
      "DOID:680",
      "EFO:0005815",
      "MEDGEN:181880",
      "MESH:D024801",
      "UMLS:C0949664"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (tau proteins) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with alzheimer disease; dementia; parkinsonian disorders; progressive supranuclear palsy (supranuclear palsy, progressive); and corticobasal degeneration."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7208,
      "label": "neurodegenerative disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1289",
          "EFO:0005772",
          "ICD9:349.89",
          "MEDGEN:17999",
          "MESH:D019636",
          "NCIT:C4802",
          "SCTID:80690008",
          "UMLS:C0027746"
        ],
        "synonyms": [
          "degenerative disease",
          "brain degeneration",
          "central nervous system degenerative disorder",
          "central nervous system neurodegenerative disorder",
          "degenerative disorder of central nervous system",
          "cerebral degeneration disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005559"
    },
    {
      "id": 29384,
      "label": "disease by molecular mechanism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "definition": "A grouping class for human diseases classified by their underlying molecular or pathophysiological mechanism, such as protein aggregation, ion channel dysfunction, or signal transduction disruption."
      },
      "child_count": 5,
      "reference_id": "MONDO:7770011"
    }
  ],
  "children": [
    {
      "id": 6717,
      "label": "Alzheimer disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3823,
        7220
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10652",
          "HP:0002511",
          "ICD10CM:G30",
          "ICD10WHO:G30",
          "ICD9:290.1",
          "ICD9:331.0",
          "MEDGEN:1853",
          "MESH:D000544",
          "NCIT:C2866",
          "Orphanet:238616",
          "SCTID:142811000119104",
          "UMLS:C0002395",
          "birnlex:2092",
          "icd11.foundation:1611724421"
        ],
        "synonyms": [
          "AD",
          "Alzheimer dementia",
          "Alzheimer disease",
          "Alzheimer's dementia",
          "Alzheimer's disease",
          "Alzheimers disease",
          "presenile and senile dementia",
          "Alzheimer disease, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004975"
    },
    {
      "id": 24725,
      "label": "argyrophilic grain disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7220
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:572581",
          "UMLS:C0338460"
        ],
        "synonyms": [
          "AGD"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A tauopathy characterized pathologically by the presence of silver stain positive lesions called argyrophilic grains, oligodendrocytic coiled bodies, and neuronal tau-positive pretangles."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700351"
    }
  ],
  "roots": [
    {
      "id": 7208,
      "label": "neurodegenerative disease"
    },
    {
      "id": 29384,
      "label": "disease by molecular mechanism"
    }
  ]
}