{
  "id": 7222,
  "label": "cryoglobulinemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005576",
  "properties": {
    "xrefs": [
      "DOID:2917",
      "EFO:0005846",
      "ICD10CM:D89.1",
      "ICD9:273.2",
      "MEDGEN:3673",
      "MESH:D003449",
      "NCIT:C26736",
      "SCTID:30911005",
      "UMLS:C0010403"
    ],
    "synonyms": [
      "cryoglobulinemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4539,
      "label": "type IV hypersensitivity disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2916",
          "MEDGEN:9371",
          "NCIT:C3115",
          "UMLS:C0020522"
        ],
        "synonyms": [
          "DTH",
          "delayed hypersensitivity reaction",
          "delayed-type hypersensitivity",
          "delayed-type hypersensitivity response",
          "disorder of type IV hypersensitivity",
          "type 4 hypersensitivity reaction",
          "type IV hypersensitivity",
          "type IV hypersensitivity reaction",
          "hypersensitivity reaction type IV disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disease that has its basis in the disruption of type IV hypersensitivity."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002459"
    },
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [
    {
      "id": 21052,
      "label": "cryofibrinogenemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7222
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:286.9",
          "MEDGEN:78798",
          "MESH:C536218",
          "SCTID:10934005",
          "UMLS:C0272263"
        ],
        "synonyms": [
          "cryofibrinogenemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0022904"
    }
  ],
  "roots": [
    {
      "id": 4539,
      "label": "type IV hypersensitivity disease"
    },
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}