{
  "id": 7223,
  "label": "arthritic joint disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005578",
  "properties": {
    "xrefs": [
      "DOID:848",
      "EFO:0005856",
      "MEDGEN:2043",
      "MESH:D001168",
      "NCIT:C2883",
      "SCTID:3723001",
      "UMLS:C0003864",
      "Wikipedia:Arthritis"
    ],
    "synonyms": [
      "arthritis",
      "inflammation of skeletal joint",
      "skeletal joint inflammation",
      "inflammatory disorder of joint"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 4665,
      "label": "bone inflammation disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7061
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3342",
          "MEDGEN:10492",
          "MESH:D010000",
          "SCTID:274144001",
          "UMLS:C0029400"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Inflammation of the bone."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002614"
    },
    {
      "id": 8264,
      "label": "arthropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6893
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:381",
          "EFO:1000999",
          "ICD9:711",
          "ICD9:716.80",
          "ICD9:716.88",
          "ICD9:716.9",
          "ICD9:716.90",
          "ICD9:716.98",
          "ICD9:719.80",
          "ICD9:719.88",
          "ICD9:719.89",
          "ICD9:719.9",
          "ICD9:719.90",
          "ICD9:719.98",
          "MEDGEN:7190",
          "MESH:D007592",
          "MedDRA:10003285",
          "NCIT:C35760",
          "SCTID:399269003",
          "UMLS:C0022408"
        ],
        "synonyms": [
          "Joint disorder",
          "arthropathy",
          "disease of skeletal joint",
          "disease or disorder of skeletal joint",
          "disorder of skeletal joint",
          "disorder, Joint",
          "skeletal joint disease",
          "skeletal joint disease or disorder",
          "Joint ankylosis of the ankle and foot",
          "Joint ankylosis of the forearm",
          "Joint ankylosis of the hand",
          "Joint ankylosis of the lower leg",
          "Joint ankylosis of the pelvic region and thigh",
          "Joint ankylosis of the shoulder region",
          "Joint ankylosis of the upper arm",
          "ankylosis of ankle and foot joint",
          "ankylosis of forearm joint",
          "ankylosis of hand joint",
          "ankylosis of joint of multiple sites",
          "ankylosis of joint of pelvic region and thigh",
          "ankylosis of joint of shoulder region",
          "ankylosis of lower leg joint",
          "ankylosis of multiple joints",
          "ankylosis of upper arm joint",
          "infectious arthropathy",
          "arthrosis",
          "disorder of joint",
          "joint disease",
          "joint disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Any disorder of the joints."
      },
      "child_count": 24,
      "reference_id": "MONDO:0006816"
    },
    {
      "id": 20399,
      "label": "inflammatory disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:799.89",
          "MEDGEN:452939",
          "NCIT:C93210",
          "SCTID:128139000",
          "UMLS:C1290884"
        ],
        "synonyms": [
          "anatomical structure inflammation",
          "inflammation of anatomical structure",
          "inflammatory disease",
          "inflammatory disorder"
        ],
        "definition": "A disease involving a pathogenic inflammatory response in the anatomical structure."
      },
      "child_count": 94,
      "reference_id": "MONDO:0021166"
    }
  ],
  "children": [
    {
      "id": 3545,
      "label": "chondrocalcinosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6795,
        7223,
        25070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1156",
          "HP:0000934",
          "ICD9:275.49",
          "ICD9:712.1",
          "MEDGEN:154303",
          "MESH:D002805",
          "NCIT:C34955",
          "SCTID:239832006",
          "UMLS:C0553730",
          "icd11.foundation:2041797033"
        ],
        "synonyms": [
          "calcium pyrophosphate deposition disease",
          "pseudogout"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An acute episode of pain, swelling, and redness, sometimes associated with fever. It is caused by the deposition of calcium pyrophosphate crystals in the joints."
      },
      "child_count": 9,
      "reference_id": "MONDO:0001314"
    },
    {
      "id": 4327,
      "label": "transient arthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3648,
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2092",
          "ICD9:716.4",
          "MEDGEN:854445",
          "SCTID:6011000119108",
          "UMLS:C3887596",
          "icd11.foundation:846745561"
        ],
        "synonyms": [
          "transient arthropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Arthritis that is not permanent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002204"
    },
    {
      "id": 4490,
      "label": "synovitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5762,
        7223,
        23249,
        23662
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2703",
          "EFO:0008997",
          "HP:0100769",
          "MEDGEN:21051",
          "MESH:D013585",
          "NCIT:C50766",
          "SCTID:416209007",
          "UMLS:C0039103"
        ],
        "synonyms": [
          "inflammation of synovial membrane of synovial joint",
          "synovial membrane of synovial joint inflammation",
          "synovitis",
          "synovitis (disease)",
          "Synovitides"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Inflammation of a synovial membrane."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002400"
    },
    {
      "id": 6899,
      "label": "osteoarthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8398",
          "HP:0002758",
          "ICD10CM:M15-M19",
          "ICD10CM:M19",
          "ICD9:715.3",
          "MEDGEN:45244",
          "MESH:D010003",
          "NCIT:C3293",
          "SCTID:396275006",
          "UMLS:C0029408",
          "icd11.foundation:558562409"
        ],
        "synonyms": [
          "degenerative joint disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A noninflammatory degenerative joint disease occurring chiefly in older persons, characterized by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity."
      },
      "child_count": 5,
      "reference_id": "MONDO:0005178"
    },
    {
      "id": 8336,
      "label": "periarthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4551,
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2964",
          "EFO:1001097",
          "MEDGEN:45397",
          "MESH:D010489",
          "MedDRA:10034464",
          "SCTID:50921008",
          "UMLS:C0031037"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Inflammation of the tissues around a joint. (Dorland, 27th ed)"
      },
      "child_count": 2,
      "reference_id": "MONDO:0006898"
    },
    {
      "id": 9682,
      "label": "rheumatoid arthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3005,
        7203,
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7148",
          "EFO:0000685",
          "HP:0001370",
          "ICD9:714.0",
          "MEDGEN:2078",
          "MESH:D001172",
          "NCIT:C2884",
          "OMIM:180300",
          "Orphanet:284130",
          "SCTID:69896004",
          "UMLS:C0003873",
          "icd11.foundation:576319925"
        ],
        "synonyms": [
          "RA",
          "rheumatoid arthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor."
      },
      "child_count": 21,
      "reference_id": "MONDO:0008383"
    },
    {
      "id": 12534,
      "label": "juvenile idiopathic arthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7203,
        7223,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:676",
          "EFO:0002609",
          "GARD:0018677",
          "ICD9:714.3",
          "ICD9:714.31",
          "ICD9:714.33",
          "MEDGEN:760659",
          "MESH:D001171",
          "MedDRA:10059177",
          "NANDO:1200469",
          "NANDO:2200415",
          "NCIT:C114357",
          "NORD:808",
          "OMIM:604302",
          "Orphanet:92",
          "SCTID:410502007",
          "UMLS:C3495559",
          "icd11.foundation:1322678686"
        ],
        "synonyms": [
          "Arthritis, Juvenile Rheumatoid",
          "JIA",
          "Juvenile idiopathic arthritis",
          "juvenile idiopathic arthritis",
          "juvenile rheumatoid arthritis",
          "rheumatoid arthritis, systemic juvenile, susceptibility to",
          "acute juvenile rheumatoid arthritis",
          "monarticular juvenile rheumatoid arthritis",
          "pauciarticular juvenile arthritis",
          "pauciarticular onset juvenile chronic arthritis",
          "systemic juvenile rheumatoid arthritis",
          "juvenile chronic arthritis",
          "juvenile chronic polyarthritis",
          "rheumatoid arthritis, systemic juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Juvenile idiopathic arthritis (JIA) is the term used to describe a group of inflammatory articular disorders of unknown cause that begin before the age of 16 and last over 6 weeks. The term juvenile idiopathic arthritis was chosen to signify the absence of any known mechanism underlying the disorder and to highlight the necessity of excluding other types of arthritis occurring in well defined diseases (in particular arthritis occurring in association with infectious, inflammatory and haematooncologic diseases)."
      },
      "child_count": 18,
      "reference_id": "MONDO:0011429"
    },
    {
      "id": 17686,
      "label": "reactive arthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7203,
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6196",
          "EFO:0007460",
          "GARD:0005693",
          "ICD9:099.3",
          "ICD9:711.3",
          "ICD9:711.30",
          "ICD9:711.40",
          "MEDGEN:39047",
          "MESH:D016918",
          "MedDRA:10003267",
          "MedDRA:10038294",
          "NCIT:C128332",
          "NORD:1650",
          "Orphanet:29207",
          "SCTID:129133005",
          "UMLS:C0085435"
        ],
        "synonyms": [
          "Fiessinger-Leroy disease",
          "Fiessinger-Leroy-Reiter syndrome",
          "Reiter syndrome",
          "Reiter's disease",
          "Reiter's syndrome",
          "arthritis urethritica",
          "polyarthritis enterica",
          "reactive arthritis",
          "venereal arthritis",
          "PIRA",
          "post-infectious arthritis",
          "post-infectious reactive arthropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017376"
    },
    {
      "id": 19191,
      "label": "adult-onset Still disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7223,
        19503
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14256",
          "EFO:0007135",
          "GARD:0000436",
          "ICD10CM:M06.1",
          "ICD9:714.2",
          "ICD9:759.89",
          "MEDGEN:39007",
          "MESH:D016706",
          "MedDRA:10058493",
          "MedDRA:10064056",
          "NANDO:1200282",
          "NORD:737",
          "Orphanet:829",
          "SCTID:239920006",
          "SCTID:68190001",
          "UMLS:C0085253",
          "icd11.foundation:549009522"
        ],
        "synonyms": [
          "AOSD",
          "Adult-Onset Still's Disease",
          "Wissler-Fanconi syndrome",
          "adult-onset Still disease",
          "adult-onset Still's disease",
          "Still's disease adult onset",
          "adult Still's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019355"
    },
    {
      "id": 21316,
      "label": "polyarticular arthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:56408",
          "NCIT:C26996",
          "SCTID:416956002",
          "UMLS:C0162323"
        ],
        "synonyms": [
          "polyarthritis",
          "polyarticular arthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An arthritis affecting five or more separate joints."
      },
      "child_count": 2,
      "reference_id": "MONDO:0024280"
    },
    {
      "id": 23059,
      "label": "infective arthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200,
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006781",
          "MEDGEN:13918",
          "NCIT:C26700",
          "UMLS:C0003869"
        ],
        "synonyms": [
          "infective arthritis",
          "septic arthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "The inflammation of one or more joints caused by any infectious pathogen within the joint space. Symptoms include pain, stiffness, and decreased range of motion in the affected joint."
      },
      "child_count": 4,
      "reference_id": "MONDO:0042485"
    },
    {
      "id": 23143,
      "label": "negative rheumatoid factor polyarthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:444150",
          "MESH:C538347",
          "NANDO:2201057",
          "UMLS:C2931825"
        ],
        "synonyms": [
          "RF-ve CP",
          "rheumatoid factor negative erosive chronic polyarthritis",
          "rheumatoid factor-negative polyarthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0043152"
    },
    {
      "id": 23172,
      "label": "hemophilic arthropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:M36.2",
          "MEDGEN:120487",
          "NCIT:C27039",
          "SCTID:80813006",
          "UMLS:C0263725"
        ],
        "synonyms": [
          "hemophilic arthritis",
          "hemophilic arthropathy",
          "arthropathy in haemophilia",
          "arthropathy in hemophilia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A form of arthritis that affects hemophiliacs, which is characterized by bleeding into the joint space."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043240"
    }
  ],
  "roots": [
    {
      "id": 4665,
      "label": "bone inflammation disease"
    },
    {
      "id": 8264,
      "label": "arthropathy"
    },
    {
      "id": 20399,
      "label": "inflammatory disease"
    }
  ]
}