{
  "id": 7225,
  "label": "esophageal squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005580",
  "properties": {
    "xrefs": [
      "DOID:3748",
      "EFO:0005922",
      "GARD:0018901",
      "MEDGEN:124635",
      "MESH:C562729",
      "MESH:D000077277",
      "NCIT:C4024",
      "ONCOTREE:ESCC",
      "Orphanet:99977",
      "SCTID:276804009",
      "UMLS:C0279626",
      "icd11.foundation:1417891145"
    ],
    "synonyms": [
      "ESCC",
      "esophageal epidermoid carcinoma",
      "esophageal scc",
      "esophageal squamous cell cancer",
      "esophageal squamous cell carcinoma",
      "esophagus scc",
      "esophagus squamous cell carcinoma",
      "oesophagus scc",
      "scc of esophagus",
      "scc of the esophagus",
      "scc of the oesophagus",
      "squamous cell car. - esophagus",
      "squamous cell car. - oesophagus",
      "squamous cell carcinoma of esophagus",
      "squamous cell carcinoma of oesophagus",
      "squamous cell carcinoma of the esophagus",
      "squamous cell carcinoma of the oesophagus"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma (EC) that can affect any part of the esophagus, but is usually located in the upper or middle third."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7738,
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1107",
          "EFO:0002916",
          "GARD:0006383",
          "MEDGEN:56256",
          "MedDRA:10030155",
          "NCIT:C3513",
          "Orphanet:70482",
          "SCTID:372138000",
          "UMLS:C0152018"
        ],
        "synonyms": [
          "Esophageal cancer",
          "carcinoma of esophagus",
          "carcinoma of the esophagus",
          "carcinoma of the oesophagus",
          "esophageal carcinoma",
          "esophagus carcinoma",
          "oesophagus carcinoma",
          "cancer of esophagus",
          "cancer of oesophagus",
          "cancer of the esophagus",
          "cancer of the oesophagus",
          "esophageal cancer",
          "esophageal cancer, NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)."
      },
      "child_count": 10,
      "reference_id": "MONDO:0019086"
    }
  ],
  "children": [
    {
      "id": 4796,
      "label": "esophagus verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7225,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3747",
          "GARD:0023238",
          "MEDGEN:272594",
          "NCIT:C27420",
          "UMLS:C1333470"
        ],
        "synonyms": [
          "esophageal verrucous cancer",
          "esophageal verrucous carcinoma",
          "esophagus verrucous carcinoma",
          "verrucous carcinoma of esophagus",
          "verrucous carcinoma of the esophagus",
          "verrucous carcinoma of the oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare variant of esophageal squamous cell carcinoma. It is an exophytic, cauliflower-like or papillary mass that can arise in any part of the esophagus. This variant of squamous cell carcinoma grows slowly and invades locally, with a very low metastasizing potential. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0002762"
    },
    {
      "id": 5454,
      "label": "esophageal adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7225,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5625",
          "GARD:0023558",
          "MEDGEN:389165",
          "NCIT:C27421",
          "UMLS:C2063886"
        ],
        "synonyms": [
          "esophageal adenosquamous cancer",
          "esophageal adenosquamous carcinoma",
          "esophagus adenosquamous carcinoma",
          "oesophagus adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An esophageal carcinoma characterized by the presence of distinguishable squamous and glandular carcinomatous components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003550"
    },
    {
      "id": 5928,
      "label": "esophageal basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        7225
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7051",
          "GARD:0023816",
          "MEDGEN:232156",
          "NCIT:C7032",
          "UMLS:C1333443"
        ],
        "synonyms": [
          "basaloid squamous carcinoma of esophagus",
          "basaloid squamous carcinoma of oesophagus",
          "esophageal basaloid cancer",
          "esophageal basaloid carcinoma",
          "basaloid squamous carcinoma of the esophagus",
          "basaloid squamous carcinoma of the oesophagus",
          "esophageal basaloid squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare morphologic variant of esophageal squamous cell carcinoma. Histologically, it is composed of closely packed cells with hyperchromatic nuclei and scant basophilic cytoplasm. It has a similar prognosis to the conventional squamous cell carcinoma of the esophagus. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004093"
    },
    {
      "id": 18520,
      "label": "undifferentiated carcinoma of esophagus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7225,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021742",
          "MEDGEN:412163",
          "NCIT:C27422",
          "Orphanet:418951",
          "UMLS:C2188058"
        ],
        "synonyms": [
          "esophageal undifferentiated carcinoma",
          "esophagus undifferentiated carcinoma",
          "oesophagus undifferentiated carcinoma",
          "undifferentiated esophageal cancer",
          "undifferentiated esophageal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An esophageal carcinoma characterized by the absence of microscopic features of squamous differentiation. However, there is immunohistochemical evidence of squamous differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018481"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus"
    }
  ]
}