{
  "id": 7234,
  "label": "breast ductal adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005590",
  "properties": {
    "xrefs": [
      "DOID:3007",
      "EFO:0006318",
      "MEDGEN:315942",
      "MESH:D018270",
      "NCIT:C4017",
      "UMLS:C1527349"
    ],
    "synonyms": [
      "duct adenocarcinoma",
      "duct carcinoma",
      "ductal adenocarcinoma",
      "ductal carcinoma",
      "breast ductal carcinoma",
      "ductal breast adenocarcinoma",
      "ductal breast carcinoma",
      "ductal carcinoma of breast",
      "ductal carcinoma of the breast",
      "mammary duct adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A breast carcinoma arising from the ducts. While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast. Ductal carcinomas account for about two thirds of all breast cancers. Two types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. The latter often spreads to the axillary lymph nodes and other anatomic sites. The two forms of ductal carcinoma often coexist."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6729,
      "label": "breast adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6712,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3458",
          "EFO:0000304",
          "MEDGEN:167809",
          "NCIT:C5214",
          "UMLS:C0858252"
        ],
        "synonyms": [
          "adenocarcinoma of breast",
          "adenocarcinoma of the breast",
          "breast adenocarcinoma",
          "mammary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the breast"
      },
      "child_count": 39,
      "reference_id": "MONDO:0004988"
    }
  ],
  "children": [
    {
      "id": 5440,
      "label": "breast papillary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        7234
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5592",
          "MEDGEN:818226",
          "NCIT:C9134",
          "UMLS:C3812899"
        ],
        "synonyms": [
          "Papillary breast cancer",
          "breast papillary carcinoma",
          "papillary breast carcinoma",
          "papillary carcinoma of breast",
          "papillary carcinoma of the breast",
          "breast solid papillary carcinoma",
          "solid papillary carcinoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast carcinoma characterized by the formation of irregular, finger-like projections of fibrous stroma covered with neoplastic epithelial cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003532"
    },
    {
      "id": 5793,
      "label": "breast apocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5169,
        7234
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6581",
          "GARD:0027657",
          "MEDGEN:272319",
          "NCIT:C5141",
          "UMLS:C1332316"
        ],
        "synonyms": [
          "apocrine adenocarcinoma of breast",
          "apocrine breast carcinoma",
          "apocrine carcinoma of breast",
          "apocrine carcinoma of the breast",
          "breast apocrine adenocarcinoma",
          "breast apocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An adenocarcinoma of the breast characterized by the presence of two intermingled cellular components: cells with abundant granular, eosinophilic cytoplasm, and cells with abundant cytoplasm containing fine empty vacuoles."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003934"
    },
    {
      "id": 6698,
      "label": "invasive ductal breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7234,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3008",
          "EFO:0000186",
          "ICD9:174.8",
          "ICDO:8500/3",
          "ICDO:8521/3",
          "MEDGEN:730612",
          "NCIT:C4194",
          "ONCOTREE:IDC",
          "SCTID:408643008",
          "UMLS:C1412014"
        ],
        "synonyms": [
          "infiltrating ductal adenocarcinoma",
          "infiltrating ductal breast carcinoma",
          "infiltrating ductal carcinoma",
          "infiltrating ductal carcinoma of breast",
          "infiltrating ductal carcinoma of the breast",
          "invasive ductal adenocarcinoma",
          "invasive ductal breast carcinoma",
          "invasive ductal carcinoma",
          "invasive ductal carcinoma of breast",
          "invasive ductal carcinoma of the breast",
          "invasive ductal carcinoma, NST",
          "invasive ductal carcinoma, No specific type",
          "breast invasive ductal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both."
      },
      "child_count": 20,
      "reference_id": "MONDO:0004953"
    },
    {
      "id": 6758,
      "label": "ductal breast carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5172,
        5857,
        6442,
        7234
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060074",
          "EFO:0000432",
          "ICDO:8500/2",
          "MEDGEN:765",
          "MESH:D002285",
          "NCIT:C2924",
          "ONCOTREE:DCIS",
          "UMLS:C0007124"
        ],
        "synonyms": [
          "DCIS",
          "carcinoma in situ of mammary duct",
          "ductal breast carcinoma in situ",
          "ductal carcinoma in situ",
          "ductal carcinoma in situ (DCIS)",
          "ductal carcinoma in situ of breast",
          "ductal carcinoma in situ of the breast",
          "intraductal breast carcinoma",
          "intraductal carcinoma",
          "intraductal carcinoma of breast",
          "intraductal carcinoma of the breast",
          "mammary duct carcinoma in situ",
          "mammary duct in situ carcinoma",
          "non-infiltrating ductal adenocarcinoma of breast",
          "non-infiltrating ductal adenocarcinoma of the breast",
          "non-infiltrating ductal breast adenocarcinoma",
          "non-infiltrating ductal breast carcinoma",
          "non-infiltrating ductal carcinoma of breast",
          "non-infiltrating ductal carcinoma of the breast",
          "non-infiltrating intraductal adenocarcinoma",
          "non-infiltrating intraductal adenocarcinoma of breast",
          "non-infiltrating intraductal adenocarcinoma of the breast",
          "non-infiltrating intraductal breast adenocarcinoma",
          "non-infiltrating intraductal carcinoma",
          "non-invasive ductal adenocarcinoma of breast",
          "non-invasive ductal adenocarcinoma of the breast",
          "non-invasive ductal breast adenocarcinoma",
          "non-invasive ductal breast carcinoma",
          "non-invasive ductal carcinoma of breast",
          "non-invasive ductal carcinoma of the breast",
          "non-invasive intraductal adenocarcinoma of breast",
          "non-invasive intraductal adenocarcinoma of the breast",
          "non-invasive intraductal breast adenocarcinoma",
          "stage 0 mammary duct carcinoma",
          "breast ductal carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005023"
    }
  ],
  "roots": [
    {
      "id": 6729,
      "label": "breast adenocarcinoma"
    }
  ]
}