{
  "id": 7238,
  "label": "severe cutaneous adverse reaction",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005594",
  "properties": {
    "xrefs": [
      "EFO:0006346",
      "MEDGEN:1843455",
      "MESH:D002921",
      "MedDRA:20000020",
      "UMLS:C5554042"
    ],
    "synonyms": [
      "SCAR"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A group of skin disorders including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6820,
      "label": "skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:37",
          "EFO:0000701",
          "ICD9:702",
          "ICD9:702.8",
          "ICD9:709.8",
          "MEDGEN:20777",
          "MESH:D012871",
          "NANDO:2100281",
          "NCIT:C3371",
          "SCTID:95320005",
          "UMLS:C0037274"
        ],
        "synonyms": [
          "cutaneous disorder",
          "disease of zone of skin",
          "disease or disorder of zone of skin",
          "disorder of skin",
          "disorder of zone of skin",
          "skin diseases and manifestations",
          "skin disorder",
          "zone of skin disease",
          "zone of skin disease or disorder",
          "dermatosis",
          "genodermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005093"
    }
  ],
  "children": [
    {
      "id": 16203,
      "label": "drug rash with eosinophilia and systemic symptoms",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        7148,
        7238,
        17704
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013629",
          "ICD10CM:D72.12",
          "MEDGEN:762193",
          "MESH:D063926",
          "MedDRA:10058919",
          "NCIT:C112208",
          "Orphanet:139402",
          "SCTID:702809001",
          "UMLS:C3541994",
          "icd11.foundation:516577496"
        ],
        "synonyms": [
          "DHS",
          "DRESS",
          "DRESS syndrome",
          "Drug hypersensitivity syndrome",
          "Drug reaction with eosinophilia and Systemic symptoms",
          "dress",
          "drug reaction eosinophilic systemic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015340"
    },
    {
      "id": 17693,
      "label": "acute generalized exanthematous pustulosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4496,
        7238,
        17704,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021164",
          "ICD9:709.8",
          "MEDGEN:209091",
          "MESH:D056150",
          "MedDRA:10048799",
          "NCIT:C112122",
          "Orphanet:293173",
          "SCTID:702617007",
          "UMLS:C0877055"
        ],
        "synonyms": [
          "AGEP",
          "pustular drug eruption",
          "toxic pustuloderma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A widespread acute rash characterized by fever and multiple small pustules on a reddish background."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017384"
    },
    {
      "id": 23415,
      "label": "Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7238,
        19551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022066",
          "MEDGEN:783034",
          "Orphanet:506784",
          "UMLS:C3661878",
          "icd11.foundation:496418968"
        ],
        "synonyms": [
          "SJS/TEN overlap syndrome",
          "Stevens-Johnson/TEN overlap syndrome",
          "Stevens-Johnson/toxic epidermal necrolysis overlap syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0044739"
    }
  ],
  "roots": [
    {
      "id": 6820,
      "label": "skin disorder"
    }
  ]
}