{
  "id": 7239,
  "label": "laryngeal squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005595",
  "properties": {
    "xrefs": [
      "DOID:2876",
      "EFO:0006352",
      "GARD:0017908",
      "MEDGEN:83630",
      "NCIT:C4044",
      "ONCOTREE:LXSC",
      "Orphanet:494550",
      "SCTID:405822008",
      "UMLS:C0280324"
    ],
    "synonyms": [
      "epidermoid carcinoma of larynx",
      "epidermoid carcinoma of the larynx",
      "laryngeal epidermoid carcinoma",
      "laryngeal squamous cell carcinoma",
      "laryngeal throat squamous cell cancer",
      "larynx epidermoid carcinoma",
      "larynx squamous cell carcinoma",
      "squamous cell carcinoma of larynx",
      "squamous cell carcinoma of the larynx",
      "LXSC"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4457,
      "label": "laryngeal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4451,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2600",
          "GARD:0006862",
          "MEDGEN:108889",
          "NCIT:C4855",
          "SCTID:276975007",
          "UMLS:C0595989"
        ],
        "synonyms": [
          "cancer of larynx",
          "cancer of the larynx",
          "laryngeal cancer",
          "laryngeal throat cancer",
          "carcinoma of larynx",
          "carcinoma of the larynx",
          "laryngeal carcinoma",
          "larynx carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Carcinoma that arises from the laryngeal epithelium. More than 90% of laryngeal carcinomas are squamous cell carcinomas. The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002358"
    },
    {
      "id": 11332,
      "label": "head and neck squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4185,
        6823
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5520",
          "EFO:0000181",
          "GARD:0008503",
          "MEDGEN:257911",
          "MESH:C535575",
          "MedDRA:10060121",
          "NCIT:C34447",
          "OMIM:275355",
          "ONCOTREE:HNSC",
          "Orphanet:67037",
          "SCTID:716659002",
          "UMLS:C1168401"
        ],
        "synonyms": [
          "HNSCC",
          "SCCHN",
          "craniocervical region squamous cell carcinoma",
          "head and neck squamous cell carcinoma",
          "squamous cell carcinoma of head and neck",
          "squamous cell carcinoma of the head and neck",
          "squamous cell carcinoma, head and neck, somatic",
          "carcinoma of the head and neck",
          "squamous cell carcinoma, head and neck"
        ],
        "definition": "A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands."
      },
      "child_count": 26,
      "reference_id": "MONDO:0010150"
    }
  ],
  "children": [
    {
      "id": 4800,
      "label": "larynx verrucous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7239,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3752",
          "GARD:0023239",
          "MEDGEN:76097",
          "NCIT:C8188",
          "SCTID:707427000",
          "UMLS:C0280328"
        ],
        "synonyms": [
          "laryngeal throat verrucous cancer",
          "laryngeal verrucous carcinoma",
          "larynx verrucous carcinoma",
          "verrucous carcinoma of larynx",
          "verrucous carcinoma of the larynx"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A well differentaited, non-metastasizing squamous cell carcinoma arising from the larynx. It is an exophytic, warty, and slow growing tumor affecting predominantly older men. It is associated with tobacco smoking. Symptoms include hoarseness, airway obstruction, weight loss, dysphagia, and throat pain. If left untreated, it may cause extensive local destruction."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002766"
    },
    {
      "id": 5916,
      "label": "glottis squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4454,
        7239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7031",
          "GARD:0023807",
          "MEDGEN:76096",
          "NCIT:C8186",
          "UMLS:C0280325"
        ],
        "synonyms": [
          "epidermoid carcinoma of glottis",
          "epidermoid carcinoma of the glottis",
          "glottic epidermoid carcinoma",
          "glottic squamous cell carcinoma",
          "glottis epidermoid carcinoma",
          "glottis squamous cell carcinoma",
          "squamous cell carcinoma of glottis",
          "squamous cell carcinoma of the glottis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma of the larynx that arises from the glottic area. It may remain localized for a long period then in late disease stage, it may spread to the opposite true vocal cord, supraglottic and subglottic areas, and the soft tissues of the neck. Hoarseness is the presenting symptom."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004080"
    },
    {
      "id": 6108,
      "label": "subglottis squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6172,
        7239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7585",
          "GARD:0023914",
          "MEDGEN:124720",
          "NCIT:C8187",
          "UMLS:C0280326"
        ],
        "synonyms": [
          "epidermoid carcinoma of subglottis",
          "epidermoid carcinoma of the subglottis",
          "squamous cell carcinoma of subglottis",
          "squamous cell carcinoma of the subglottis",
          "subglottic epidermoid carcinoma",
          "subglottic squamous cell carcinoma",
          "subglottis epidermoid carcinoma",
          "subglottis squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma of the larynx that arises from the subglottic area. Symptoms include dyspnea and stridor. It spreads to the hypopharynx, trachea, and thyroid gland."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004291"
    },
    {
      "id": 6110,
      "label": "supraglottis squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6171,
        7239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7587",
          "GARD:0023916",
          "MEDGEN:152890",
          "NCIT:C4945",
          "UMLS:C0749163"
        ],
        "synonyms": [
          "epidermoid carcinoma of supraglottis",
          "epidermoid carcinoma of the supraglottis",
          "squamous cell carcinoma of supraglottis",
          "squamous cell carcinoma of the supraglottis",
          "supraglottic epidermoid carcinoma",
          "supraglottic part of larynx squamous cell carcinoma",
          "supraglottic squamous cell carcinoma",
          "supraglottis epidermoid carcinoma",
          "supraglottis squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma of the larynx that arises from the supraglottic area. Signs and symptoms include dysphagia, a sensation of foreign body in the throat, and hemoptysis. It spreads to the space anterior to the epiglottis, pyriform sinus, and base of the tongue."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004293"
    }
  ],
  "roots": [
    {
      "id": 4457,
      "label": "laryngeal carcinoma"
    },
    {
      "id": 11332,
      "label": "head and neck squamous cell carcinoma"
    }
  ]
}