{
  "id": 7252,
  "label": "bladder transitional cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005611",
  "properties": {
    "xrefs": [
      "DOID:4006",
      "EFO:0006544",
      "MEDGEN:76013",
      "NCIT:C39851",
      "ONCOTREE:BLCA",
      "SCTID:255109008",
      "UMLS:C0279680"
    ],
    "synonyms": [
      "bladder transitional cell carcinoma",
      "bladder urothelial cancer",
      "bladder urothelial carcinoma",
      "transitional cell carcinoma of the urinary bladder",
      "urinary bladder transitional cell carcinoma",
      "urinary bladder urothelial carcinoma",
      "urothelial carcinoma of the urinary bladder",
      "BLCA"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6727,
      "label": "urinary bladder carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3431,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4007",
          "HP:0002862",
          "MEDGEN:147071",
          "NCIT:C4912",
          "SCTID:255108000",
          "UMLS:C0699885"
        ],
        "synonyms": [
          "bladder cancer",
          "cancer of bladder",
          "cancer of the bladder",
          "cancer of the urinary bladder",
          "cancer of urinary bladder",
          "urinary bladder cancer",
          "bladder carcinoma",
          "carcinoma bladder",
          "carcinoma of bladder",
          "carcinoma of the bladder",
          "carcinoma of the urinary bladder",
          "carcinoma of urinary bladder",
          "urinary bladder carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the urinary bladder"
      },
      "child_count": 18,
      "reference_id": "MONDO:0004986"
    },
    {
      "id": 23006,
      "label": "urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        7972,
        21366
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0008528",
          "GARD:0025829",
          "MEDGEN:760495",
          "NCIT:C4030",
          "UMLS:C2145472"
        ],
        "synonyms": [
          "Uroepithelial carcinoma",
          "transitional cell car. -uroth.",
          "transitional cell carcinoma of the urinary tract",
          "transitional cell carcinoma of the urothelial tract",
          "urothelial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis). It is frequently papillary."
      },
      "child_count": 15,
      "reference_id": "MONDO:0040679"
    }
  ],
  "children": [
    {
      "id": 5752,
      "label": "infiltrating bladder urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7252,
        23005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6477",
          "GARD:0023716",
          "MEDGEN:233582",
          "NCIT:C27885",
          "UMLS:C1334281"
        ],
        "synonyms": [
          "infiltrating bladder urothelial carcinoma",
          "infiltrating transitional cell carcinoma of the urinary bladder",
          "invasive bladder transitional cell carcinoma",
          "invasive bladder urothelial carcinoma",
          "invasive transitional cell carcinoma of the urinary bladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "An invasive transitional cell carcinoma that arises from the urinary bladder urothelium."
      },
      "child_count": 18,
      "reference_id": "MONDO:0003890"
    },
    {
      "id": 5789,
      "label": "non-invasive bladder urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7252
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6571",
          "GARD:0023742",
          "MEDGEN:233466",
          "NCIT:C6188",
          "UMLS:C1336089"
        ],
        "synonyms": [
          "non-invasive bladder urothelial carcinoma",
          "stage 0 bladder urothelial cancer",
          "stage 0 bladder urothelial carcinoma",
          "stage 0 bladder urothelial carcinoma aJCC v6",
          "stage 0 bladder urothelial carcinoma aJCC v6 and v7",
          "stage 0 bladder urothelial carcinoma aJCC v7",
          "stage 0 transitional cell carcinoma of bladder",
          "stage 0 transitional cell carcinoma of the bladder",
          "stage 0 transitional cell carcinoma of the urinary bladder",
          "stage 0 transitional cell carcinoma of urinary bladder",
          "stage 0 urinary bladder transitional cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0). Ta: Noninvasive papillary carcinoma. Tis: Carcinoma in situ: \"flat tumor\". N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)"
      },
      "child_count": 1,
      "reference_id": "MONDO:0003930"
    },
    {
      "id": 5897,
      "label": "bladder papillary urothelial carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5368,
        7252,
        7876
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6975",
          "GARD:0023797",
          "MEDGEN:309552",
          "NCIT:C7383",
          "UMLS:C1518882"
        ],
        "synonyms": [
          "bladder papillary urothelial carcinoma",
          "urinary bladder papillary transitional cell carcinoma",
          "urothelial papillary carcinoma of the bladder",
          "bladder urothelial papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "An invasive or non-invasive papillary transitional cell carcinoma of the urinary bladder. It is classified as low - or high-grade. -- 2003"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004056"
    },
    {
      "id": 5988,
      "label": "bladder urachal urothelial carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5596,
        7252
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7244",
          "GARD:0023857",
          "MEDGEN:267744",
          "NCIT:C39844",
          "UMLS:C1511207"
        ],
        "synonyms": [
          "bladder urachal urothelial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A transitional cell carcinoma of the urinary bladder that arises from the urachal epithelium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004163"
    },
    {
      "id": 25209,
      "label": "bladder sarcomatoid transitional cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4854,
        7252
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080901",
          "GARD:0026608"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A sarcomatoid transitional cell carcinoma that is located in the bladder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850347"
    }
  ],
  "roots": [
    {
      "id": 6727,
      "label": "urinary bladder carcinoma"
    },
    {
      "id": 23006,
      "label": "urothelial carcinoma"
    }
  ]
}