{
  "id": 7255,
  "label": "plasmacytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005615",
  "properties": {
    "xrefs": [
      "DOID:3721",
      "EFO:0006738",
      "GARD:0013446",
      "ICD9:238.6",
      "ICDO:9731/3",
      "MEDGEN:18506",
      "MESH:D010954",
      "MedDRA:10035484",
      "NCIT:C9349",
      "Orphanet:86855",
      "SCTID:415112005",
      "UMLS:C0032131",
      "icd11.foundation:1811140613"
    ],
    "synonyms": [
      "plasmacytoma",
      "solitary plasmacytoma",
      "anaplastic plasmacytoma",
      "anaplastic skeletal plasmacytoma (type)",
      "anaplastic solitary extramedullary plasmacytoma of the cecum (type)",
      "extramedullary anaplastic plasmacytoma (type)",
      "myeloma - solitary",
      "myeloma, solitary",
      "solitary myeloma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Plasmacytoma is a localized mass of neoplastic monoclonal plasma cells that represents approximately 5% of all plasma cell neoplasms. There are two separate entities: primary plasmacytoma of the bone and extramedullary plasmacytoma of the soft tissues. Of the extramedullary plasmacytomas, 80% occur in the head and neck, usually in the upper respiratory tract. The median age at diagnosis is 50 years and the male to female ratio is 3:1. Long-term survival is possible following local radiotherapy, particularly for soft tissue presentations."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6702,
      "label": "plasma cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6536",
          "EFO:0000200",
          "GARD:0019440",
          "ICD9:238.6",
          "MEDGEN:368758",
          "MESH:D054219",
          "NCIT:C4665",
          "Orphanet:98282",
          "SCTID:415111003",
          "UMLS:C1959632"
        ],
        "synonyms": [
          "plasma cell dyscrasia",
          "plasma cell neoplasm",
          "plasma cell tumor",
          "plasma cell tumor, malignant",
          "plasmacytic neoplasm",
          "plasmacytic tumor",
          "plasmacytic tumour",
          "plasma cell disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance."
      },
      "child_count": 7,
      "reference_id": "MONDO:0004959"
    }
  ],
  "children": [
    {
      "id": 4788,
      "label": "extramedullary plasmacytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3720",
          "GARD:0023233",
          "ICD10CM:C90.2",
          "ICD9:203.80",
          "ICDO:9734/3",
          "MEDGEN:75843",
          "NCIT:C4002",
          "ONCOTREE:EP",
          "SCTID:188718006",
          "UMLS:C0278619",
          "icd11.foundation:246947217"
        ],
        "synonyms": [
          "extramedullary plasmacytoma",
          "extramedullary plasmacytoma (clinical)",
          "extraosseous plasmacytoma",
          "plasmacytoma, extramedullary",
          "plasmacytoma, extramedullary (not occurring in bone)",
          "EP"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A plasma cell neoplasm arising at an extraosseous site. There is no involvement of the bone marrow. It most frequently involves the oropharynx, nasopharynx, sinuses, and larynx. Other sites of involvement include the gastrointestinal tract, central nervous system, breast, skin, lymph nodes, and bladder. A minority of patients have a monoclonal gammopathy. Treatment includes radiation therapy. Progression to plasma cell myeloma occurs in a minority of patients."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002754"
    },
    {
      "id": 4789,
      "label": "solitary osseous plasmacytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3722",
          "GARD:0023234",
          "ICD9:238.6",
          "MEDGEN:75777",
          "NCIT:C7812",
          "ONCOTREE:SPB",
          "SCTID:426336007",
          "UMLS:C0272256"
        ],
        "synonyms": [
          "isolated plasmacytoma of bone",
          "solitary plasmacytoma of bone",
          "SPB"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A localized, clonal (malignant) plasma cell infiltrate in the bone, without peripheral blood involvement. The most commonly affected bones are the vertebrae, ribs, skull, pelvis and femur. X-rays examination reveals a solitary lytic lesion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002755"
    },
    {
      "id": 4790,
      "label": "solitary plasmacytoma of chest wall",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        5839,
        7255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3723",
          "GARD:0023235",
          "MEDGEN:232340",
          "NCIT:C6711",
          "UMLS:C1332936"
        ],
        "synonyms": [
          "chest wall plasmacytoma",
          "chest wall solitary plasmacytoma",
          "plasmacytoma of chest wall",
          "solitary plasmacytoma of chest wall",
          "solitary plasmacytoma of the chest wall"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A solitary plasmacytoma that arises from the chest wall."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002756"
    },
    {
      "id": 16018,
      "label": "primary plasmacytoma of the bone",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019739",
          "Orphanet:100021"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015042"
    },
    {
      "id": 16019,
      "label": "extramedullary soft tissue plasmacytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019740",
          "MEDGEN:1842608",
          "Orphanet:100022",
          "UMLS:C2211567"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015043"
    }
  ],
  "roots": [
    {
      "id": 6702,
      "label": "plasma cell neoplasm"
    }
  ]
}