{
  "id": 7257,
  "label": "undifferentiated carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005617",
  "properties": {
    "xrefs": [
      "EFO:0006772",
      "ICDO:8020/3",
      "ICDO:8021/3",
      "MEDGEN:60010",
      "NCIT:C3692",
      "UMLS:C0205698"
    ],
    "synonyms": [
      "anaplastic carcinoma",
      "carcinoma, undifferentiated",
      "carcinoma, undifferentiated, malignant",
      "undifferentiated carcinoma"
    ],
    "definition": "A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or transitional cell differentiation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 14,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 7211,
      "label": "nut midline carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060463",
          "EFO:0005783",
          "GARD:0021852",
          "MEDGEN:312999",
          "NCIT:C45716",
          "ONCOTREE:NMCHN",
          "Orphanet:443167",
          "UMLS:C1707291",
          "Wikipedia:NUT_midline_carcinoma"
        ],
        "synonyms": [
          "Midline carcinoma of children and Young adults with NUT rearrangement",
          "NMC",
          "NUT Midline carcinoma",
          "NUT carcinoma",
          "carcinoma with t(15;19)(q13;p13.1) translocation",
          "nuclear protein in testis midline carcinoma",
          "NUT midline carcinoma of the head and neck"
        ],
        "definition": "A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly the head, neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) is present that results in the creation of a fusion gene involving the NUT gene, most commonly BRD4-NUT fusion gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005563"
    },
    {
      "id": 7754,
      "label": "endometrial undifferentiated carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4530,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000242",
          "MEDGEN:274013",
          "NCIT:C40156",
          "UMLS:C1516865",
          "icd11.foundation:130578959"
        ],
        "synonyms": [
          "endometrial undifferentiated carcinoma",
          "undifferentiated endometrial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary carcinoma of the endometrium characterized by the presence of malignant cells that lack evidence of differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006199"
    },
    {
      "id": 7923,
      "label": "salivary gland large cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2972,
        6943,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000517",
          "GARD:0027753",
          "MEDGEN:810975",
          "NCIT:C35735",
          "UMLS:C2111671"
        ],
        "synonyms": [
          "large cell salivary gland carcinoma",
          "large cell undifferentiated salivary gland carcinoma",
          "saliva-secreting gland large cell carcinoma",
          "salivary gland large cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A rare, highly aggressive carcinoma that arises from the salivary gland, predominantly the parotid gland. It is characterized by the presence of large pleomorphic malignant cells with abundant cytoplasm. Patients usually present with a rapidly growing mass."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006404"
    },
    {
      "id": 7930,
      "label": "sinonasal undifferentiated carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080799",
          "EFO:1000527",
          "MEDGEN:313704",
          "MESH:C537344",
          "NCIT:C54294",
          "ONCOTREE:SNUC",
          "SCTID:697993003",
          "UMLS:C1710096"
        ],
        "synonyms": [
          "Sinonasal anaplastic carcinoma",
          "sinonasal undifferentiated carcinoma",
          "undifferentiated Sinonasal cancer",
          "SNUC",
          "highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses"
        ],
        "definition": "A rare, highly aggressive carcinoma that arises from the sinonasal tract. It is characterized by the presence of small to medium size malignant cells. The prognosis is poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006411"
    },
    {
      "id": 7958,
      "label": "thymic undifferentiated carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7257,
        7956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000580",
          "GARD:0024416",
          "MEDGEN:1864846",
          "NCIT:C35718",
          "UMLS:C2188088"
        ],
        "synonyms": [
          "thymic undifferentiated carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare primary thymic carcinoma, characterized by an undifferentiated solid tumor growth, without associated sarcomatoid features."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006455"
    },
    {
      "id": 7968,
      "label": "thyroid gland undifferentiated (anaplastic) carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6943,
        7257,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080522",
          "EFO:1000595",
          "GARD:0000664",
          "HP:0011779",
          "MEDGEN:116064",
          "MESH:D065646",
          "MedDRA:10002240",
          "NCIT:C3878",
          "ONCOTREE:THAP",
          "Orphanet:142",
          "SCTID:255031003",
          "UMLS:C0238461",
          "icd11.foundation:320540024"
        ],
        "synonyms": [
          "Dedifferentiated thyroid gland carcinoma",
          "anaplastic carcinoma of the thyroid",
          "anaplastic carcinoma of the thyroid gland",
          "anaplastic carcinoma of thyroid",
          "anaplastic carcinoma of thyroid gland",
          "anaplastic thyroid cancer",
          "anaplastic thyroid carcinoma",
          "anaplastic thyroid gland carcinoma",
          "metaplastic thyroid gland carcinoma",
          "pleomorphic thyroid gland carcinoma",
          "sarcomatoid thyroid gland carcinoma",
          "thyroid gland carcinosarcoma",
          "thyroid gland undifferentiated (anaplastic) carcinoma",
          "thyroid gland undifferentiated carcinoma",
          "undifferentiated (anaplastic) thyroid gland cancer",
          "undifferentiated (anaplastic) thyroid gland carcinoma",
          "undifferentiated carcinoma of the thyroid",
          "undifferentiated carcinoma of the thyroid gland",
          "undifferentiated carcinoma of thyroid",
          "undifferentiated carcinoma of thyroid gland",
          "undifferentiated thyroid carcinoma",
          "undifferentiated thyroid gland carcinoma",
          "undifferentiated thyroid tumor",
          "undifferentiated thyroid tumour",
          "THAP",
          "thyroid cancer, anaplastic",
          "thyroid carcinoma, anaplastic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006468"
    },
    {
      "id": 7973,
      "label": "undifferentiated gallbladder carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5174,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000604",
          "GARD:0024427",
          "MEDGEN:76010",
          "NCIT:C9167",
          "UMLS:C0279653"
        ],
        "synonyms": [
          "anaplastic carcinoma of gallbladder",
          "anaplastic carcinoma of the gallbladder",
          "anaplastic gallbladder carcinoma",
          "gall bladder undifferentiated carcinoma",
          "gallbladder undifferentiated carcinoma",
          "undifferentiated carcinoma of gallbladder",
          "undifferentiated carcinoma of the gallbladder",
          "undifferentiated gallbladder cancer",
          "undifferentiated gallbladder carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma without evidence of differentiation arising from the gallbladder. The most common variant is the spindle and giant cell type which resembles a sarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006476"
    },
    {
      "id": 7974,
      "label": "undifferentiated ovarian carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6864,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000605",
          "GARD:0024428",
          "MEDGEN:83410",
          "NCIT:C4509",
          "SCTID:254856004",
          "UMLS:C0346167"
        ],
        "synonyms": [
          "anaplastic carcinoma of ovary",
          "anaplastic carcinoma of the ovary",
          "anaplastic ovarian carcinoma",
          "ovarian undifferentiated carcinoma",
          "ovary undifferentiated carcinoma",
          "undifferentiated carcinoma of ovary",
          "undifferentiated carcinoma of the ovary",
          "undifferentiated ovarian cancer",
          "undifferentiated ovarian carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive carcinoma arising from the ovary. Most patients present with advanced disease. Microscopically, it is characterized by significant cytologic atypia, increased mitotic activity, and necrosis. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006477"
    },
    {
      "id": 7975,
      "label": "undifferentiated pancreatic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6905,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000606",
          "GARD:0027757",
          "MEDGEN:237030",
          "NCIT:C5722",
          "ONCOTREE:UCP",
          "UMLS:C1336861"
        ],
        "synonyms": [
          "pancreas undifferentiated carcinoma",
          "pancreatic carcinosarcoma",
          "pleomorphic large cell pancreatic carcinoma",
          "sarcomatoid pancreatic carcinoma",
          "spindle cell pancreatic carcinoma",
          "undifferentiated (anaplastic) pancreatic carcinoma",
          "undifferentiated carcinoma of pancreas",
          "undifferentiated carcinoma of the pancreas",
          "undifferentiated pancreatic carcinoma",
          "UCP"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma with poor prognosis that arises from the pancreas. It is characterized by the presence of a significant malignant component that does not show differentiation. The malignant cells represent a mixture of large, pleomorphic cells and giant cells, or adenocarcinoma cells and spindle cells, or spindle cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006478"
    },
    {
      "id": 16830,
      "label": "undifferentiated carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7257,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020480",
          "ICD10CM:C54.9",
          "MEDGEN:1638762",
          "Orphanet:213721",
          "UMLS:C4707822"
        ],
        "synonyms": [
          "body of uterus undifferentiated carcinoma",
          "endometrial undifferentiated carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Undifferentiated carcinoma of the corpus uteri is a rare cancer of corpus uteri presenting as a large, polypoid, intraluminal mass with necrosis, composed of small to intermediate-size, relatively uniform, dyshesive cells displaying no differentiation. It usually presents with dysfunctional bleeding or vaginal discharge and, less often, abdominal pain. Association with Lynch syndrome was reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016267"
    },
    {
      "id": 18520,
      "label": "undifferentiated carcinoma of esophagus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7225,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021742",
          "MEDGEN:412163",
          "NCIT:C27422",
          "Orphanet:418951",
          "UMLS:C2188058"
        ],
        "synonyms": [
          "esophageal undifferentiated carcinoma",
          "esophagus undifferentiated carcinoma",
          "oesophagus undifferentiated carcinoma",
          "undifferentiated esophageal cancer",
          "undifferentiated esophageal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An esophageal carcinoma characterized by the absence of microscopic features of squamous differentiation. However, there is immunohistochemical evidence of squamous differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018481"
    },
    {
      "id": 18538,
      "label": "undifferentiated carcinoma of stomach",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6695,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021759",
          "MEDGEN:237029",
          "NCIT:C5476",
          "ONCOTREE:USTAD",
          "Orphanet:423786",
          "SCTID:766757006",
          "UMLS:C1336858"
        ],
        "synonyms": [
          "Gastric undifferentiated carcinoma",
          "anaplastic carcinoma of stomach",
          "anaplastic carcinoma of the stomach",
          "anaplastic gastric carcinoma",
          "stomach undifferentiated carcinoma",
          "undifferentiated carcinoma of stomach",
          "undifferentiated carcinoma of the stomach",
          "undifferentiated gastric (stomach) cancer",
          "undifferentiated gastric carcinoma",
          "undifferentiated stomach adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the stomach and is characterized by the absence of microscopic features of glandular or squamous differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018504"
    },
    {
      "id": 18552,
      "label": "undifferentiated carcinoma of liver and intrahepatic biliary tract",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7257,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021788",
          "MEDGEN:1656437",
          "Orphanet:424970",
          "UMLS:C4749401"
        ],
        "synonyms": [
          "undifferentiated carcinoma of liver and IBT"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Undifferentiated carcinoma of liver and intrahepatic biliary tract is an extremely rare epithelial tumor of the liver and biliary tract which presents heterogenous histological findings and not yet fully defined clinicopathological characteristics. Patients usually present with nonspecific signs and symptoms, such as abdominal pain, nausea, vomiting, anorexia, weight loss and/or jaundice. Invasive growth, high metastatic potential and a rapid clinical course are typically associated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018533"
    },
    {
      "id": 20653,
      "label": "undifferentiated carcinoma of nasopharynx",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7257,
        16301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025334",
          "MEDGEN:124650",
          "NCIT:C8023",
          "SCTID:422541001",
          "UMLS:C0279748",
          "icd11.foundation:584112926"
        ],
        "synonyms": [
          "lymphoepithelioma of nasopharynx",
          "lymphoepithelioma of the nasopharynx",
          "nasopharyngeal lymphoepithelioma",
          "nasopharyngeal nonkeratinizing undifferentiated carcinoma",
          "nasopharyngeal undifferentiated carcinoma",
          "nasopharynx undifferentiated carcinoma",
          "undifferentiated carcinoma of the nasopharynx",
          "undifferentiated nasopharyngeal throat cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A undifferentiated carcinoma that involves the nasopharynx."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021537"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}