{
  "id": 7262,
  "label": "autoimmune thyroid disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005623",
  "properties": {
    "xrefs": [
      "EFO:0006812",
      "MEDGEN:183088",
      "MESH:D013967",
      "UMLS:C0920350",
      "Wikipedia:Autoimmune_thyroiditis"
    ],
    "synonyms": [
      "autoimmune thyroid gland inflammation",
      "autoimmune thyroiditides",
      "autoimmune thyroiditis",
      "lymphocytic thyroiditides",
      "lymphocytic thyroiditis",
      "lymphomatous thyroiditides",
      "lymphomatous thyroiditis",
      "thyroiditides, autoimmune",
      "thyroiditides, lymphocytic",
      "thyroiditides, lymphomatous",
      "thyroiditis, lymphocytic",
      "thyroiditis, lymphomatous"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 2997,
      "label": "autoimmune disorder of endocrine system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060005",
          "ICD9:279.49",
          "MEDGEN:575099",
          "SCTID:237822008",
          "UMLS:C0342552"
        ],
        "synonyms": [
          "endocrine system autoimmune disease",
          "endocrine system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the endocrine system."
      },
      "child_count": 26,
      "reference_id": "MONDO:0000569"
    },
    {
      "id": 5955,
      "label": "thyroiditis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7166",
          "HP:0100646",
          "ICD10CM:E06",
          "ICD10WHO:E06",
          "ICD9:245",
          "ICD9:245.9",
          "MEDGEN:21548",
          "MESH:D013966",
          "NCIT:C26894",
          "SCTID:82119001",
          "UMLS:C0040147",
          "icd11.foundation:587793334"
        ],
        "synonyms": [
          "inflammation of thyroid gland",
          "thyroid gland inflammation",
          "thyroiditis",
          "thyroiditis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Inflammation of the thyroid gland. This category includes Hashimoto thyroiditis, Riedel thyroiditis, acute thyroiditis, subacute thyroiditis, and radiation-induced thyroiditis."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004126"
    }
  ],
  "children": [
    {
      "id": 7047,
      "label": "Graves disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3354,
        7262,
        29358
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12361",
          "EFO:0004237",
          "ICD9:242.0",
          "MEDGEN:6677",
          "MESH:D006111",
          "NANDO:2200328",
          "NCIT:C3071",
          "SCTID:353295004",
          "UMLS:C0018213"
        ],
        "synonyms": [
          "Graves disease",
          "Basedow disease",
          "Graves' hyperthyroidism",
          "parry disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005364"
    },
    {
      "id": 7263,
      "label": "atrophic thyroiditis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7262
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006813",
          "MEDGEN:536775",
          "NANDO:2200336",
          "SCTID:83664006",
          "UMLS:C0238183"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Atrophic thyroiditis is an organ-specific autoimmune disease characterized by thyroid autoantibodies, functional hypothyroidism, and absence of goiter."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005624"
    },
    {
      "id": 9054,
      "label": "Hashimoto thyroiditis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7262
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7188",
          "EFO:0003779",
          "ICD10CM:E06.3",
          "ICD9:245.2",
          "MEDGEN:151769",
          "MESH:D050031",
          "NANDO:2200335",
          "NCIT:C27191",
          "OMIM:140300",
          "Orphanet:855",
          "UMLS:C0677607",
          "Wikipedia:Hashimoto's_thyroiditis",
          "icd11.foundation:972507934"
        ],
        "synonyms": [
          "lymphocytic thyroiditis",
          "Hashimoto disease",
          "Hashimoto hypothyroidism",
          "Hashimoto thyroiditis",
          "Hashimoto's disease",
          "Hashimoto's syndrome",
          "Hashimoto's thyroiditis",
          "chronic lymphocytic thyroiditis",
          "HT",
          "Hashimoto struma",
          "Hashimoto syndrome",
          "Hashimoto thyroiditides",
          "Hashimoto's struma",
          "Hashimoto's syndromes",
          "Hashimotos disease",
          "Hashimotos syndrome",
          "Ht",
          "autoimmune thyroiditis",
          "chronic lymphocytic thyroiditides",
          "disease, Hashimoto",
          "disease, Hashimoto's",
          "hypothyroidism, autoimmune",
          "hypothyroidism, autoimmune thyroid autoantibodies, included",
          "lymphocytic thyroiditides, chronic",
          "lymphocytic thyroiditis, chronic",
          "syndrome, Hashimoto's",
          "syndromes, Hashimoto's",
          "thyroid autoantibodies",
          "thyroiditides, Hashimoto",
          "thyroiditides, chronic lymphocytic",
          "thyroiditis, Hashimoto",
          "thyroiditis, chronic lymphocytic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autoimmune disorder caused by the production of autoantibodies against thyroid tissue. There is progressive destruction of the thyroid follicles leading to hypothyroidism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007699"
    },
    {
      "id": 18908,
      "label": "IgG4-related thyroid disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7262,
        17611
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14351",
          "GARD:0018866",
          "MEDGEN:509536",
          "MedDRA:10039142",
          "NCIT:C35827",
          "Orphanet:64744",
          "SCTID:89024000",
          "UMLS:C0154162",
          "icd11.foundation:1357889668"
        ],
        "synonyms": [
          "Riedel disease",
          "Riedel fibrosing thyroiditis",
          "Riedel thyroiditis",
          "Riedel's fibrosing thyroiditis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Riedel thyroiditis is a fibroinflammatory disorder of the thyroid gland, occurring more frequently in females, characterized a large, hard thyroid mass, and presenting with pressure symptoms (breathing difficulB,ties and dysphagia) or voice hoarseness and aphonia (impingement of recurrent laryngeal nerve). It can often be associated with extracervical fibroinflammatory disorders such as retroperitoneal fibrosis, primary scleroisng cholangitis and autoimmune diseases such as Hashimoto struma, Addison disease, and Biermer disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018992"
    },
    {
      "id": 23274,
      "label": "postpartum thyroiditis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7262,
        23273
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001403",
          "MEDGEN:78787",
          "MESH:D050032",
          "NCIT:C114389",
          "SCTID:52772002",
          "UMLS:C0271815",
          "icd11.foundation:1577113218"
        ],
        "synonyms": [
          "postpartum thyroiditis",
          "post partum thyroiditis",
          "post-partum thyroiditides",
          "post-partum thyroiditis",
          "postpartum thyroiditides",
          "thyroiditides, post-partum",
          "thyroiditides, postpartum",
          "thyroiditis, post-partum",
          "thyroiditis, postpartum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A transient autoimmune Inflammatory disorder of thyroid gland that occurs postpartum due to any partum problem. It is characterized by the presence of high titers of autoantibodies against thyroid peroxidase and thyroglobulin. Clinical signs include the triphasic thyroid hormone pattern: beginning with thyrotoxicosis, followed with hypothyroidism, then return to euthyroid state by 1 year postpartum"
      },
      "child_count": 0,
      "reference_id": "MONDO:0044014"
    }
  ],
  "roots": [
    {
      "id": 2997,
      "label": "autoimmune disorder of endocrine system"
    },
    {
      "id": 5955,
      "label": "thyroiditis"
    }
  ]
}