{ "id": 7266, "label": "head and neck cancer", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0005627", "properties": { "xrefs": [ "DOID:11934", "EFO:0006859", "MEDGEN:78920", "NCIT:C4013", "UMLS:C0278996" ], "synonyms": [ "head and neck neoplasm", "head and neck tumors", "head and neck tumours", "head/neck neoplasm", "tumour of head and neck", "cancer of craniocervical region", "cancer of head and neck", "cancer of the head and neck", "craniocervical region cancer", "head and neck cancer", "head and neck malignant neoplasia", "malignant craniocervical region neoplasm", "malignant head and neck neoplasm", "malignant head and neck tumor", "malignant head and neck tumour", "malignant neoplasm of craniocervical region", "malignant neoplasm of head and neck", "malignant neoplasm of the head and neck", "malignant tumor of head and neck", "malignant tumor of the head and neck", "malignant tumour of head and neck", "malignant tumour of the head and neck" ], "definition": "A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma." }, "isLeaf": false, "isRoot": false, "child_count": 16, "parents": [ { "id": 6733, "label": "cancer", "isLeaf": false, "isRoot": false, "parents": [ 6798 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050686", "DOID:0050687", "DOID:162", "ICD9:195.8", "ICD9:199", "ICD9:199.1", "ICDO:8000/3", "MEDGEN:14297", "NCIT:C9305", "ONCOTREE:MT", "SCTID:363346000", "UMLS:C0006826", "birnlex:406" ], "synonyms": [ "CA", "cancer", "cell type cancer", "malignancy", "malignant growth", "malignant neoplasm", "malignant neoplasm (disease)", "malignant neoplastic disease", "malignant tumor", "malignant tumour", "neoplasm (disease), malignant", "neoplasm, malignant", "MT" ], "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas." }, "child_count": 33, "reference_id": "MONDO:0004992" }, { "id": 7231, "label": "head and neck neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6798 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0005950", "ICD9:239.89", "MEDGEN:6728", "NCIT:C3077", "ONCOTREE:HEADNECK", "SCTID:255055008", "UMLS:C0018671" ], "synonyms": [ "craniocervical region neoplasm", "craniocervical region neoplasm (disease)", "craniocervical region tumor", "craniocervical region tumour", "head and neck neoplasm", "head and neck neoplasm (excluding central nervous system)", "head and neck tumor", "head and neck tumour", "neoplasm of craniocervical region", "neoplasm of head and neck", "neoplasm of the head and neck", "tumor of craniocervical region", "tumor of head and neck", "tumor of the head and neck", "tumour of craniocervical region", "tumour of head and neck", "tumour of the head and neck" ], "definition": "A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma." }, "child_count": 37, "reference_id": "MONDO:0005586" } ], "children": [ { "id": 3375, "label": "nasal cavity cancer", "isLeaf": false, "isRoot": false, "parents": [ 2875, 3050, 6527, 7266 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10811", "ICD10CM:C30.0", "ICD9:160.0", "MEDGEN:152601", "NCIT:C4918", "SCTID:363422006", "UMLS:C0728864", "icd11.foundation:1078206702" ], "synonyms": [ "cancer of nasal cavity", "malignant nasal cavity neoplasm", "malignant nasal cavity tumor", "malignant nasal cavity tumour", "malignant neoplasm of nasal cavities", "malignant neoplasm of nasal cavity", "malignant neoplasm of the nasal cavity", "malignant tumor of nasal cavity", "malignant tumor of the nasal cavity", "malignant tumour of nasal cavity", "malignant tumour of the nasal cavity", "nasal cavity cancer" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A malignant neoplasm involving the nasal cavity" }, "child_count": 12, "reference_id": "MONDO:0001128" }, { "id": 4185, "label": "head and neck carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6734, 7266 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1542", "MEDGEN:854345", "NCIT:C35850", "UMLS:C3887461" ], "synonyms": [ "carcinoma of craniocervical region", "carcinoma of head and neck", "carcinoma of neck", "carcinoma of the head and neck", "craniocervical region carcinoma", "head and neck carcinoma", "neck carcinoma", "carcinoma of the neck", "head and neck cancer" ], "definition": "A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma." }, "child_count": 32, "reference_id": "MONDO:0002038" }, { "id": 4265, "label": "skull cancer", "isLeaf": false, "isRoot": false, "parents": [ 4262, 7266, 21561 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1863", "GARD:0023073", "MEDGEN:1662558", "NCIT:C155790", "UMLS:C2062986" ], "synonyms": [ "cancer of skull", "malignant neoplasm of skull", "malignant skull neoplasm", "skull cancer" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0003900", "name": "connective tissue disorder" } ], "definition": "A malignant neoplasm involving the skull." }, "child_count": 18, "reference_id": "MONDO:0002132" }, { "id": 4353, "label": "ocular cancer", "isLeaf": false, "isRoot": false, "parents": [ 3050, 7266, 20431 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2174", "ICD9:190.8", "ICD9:239.89", "MEDGEN:105418", "MESH:D005134", "NCIT:C4767", "SCTID:371486001", "UMLS:C0496836" ], "synonyms": [ "eye neoplasm", "neoplasm of eye", "ocular tumor", "ocular tumour", "cancer of eye", "cancer of eyeball of camera-type eye", "cancer of the eye", "eye cancer", "eye neoplasm, malignant", "eyeball of camera-type eye cancer", "malignant eye neoplasm", "malignant eye tumor", "malignant eye tumour", "malignant eyeball of camera-type eye neoplasm", "malignant neoplasm of eye", "malignant neoplasm of eyeball of camera-type eye", "malignant neoplasm of the eye", "malignant ocular neoplasm", "malignant ocular tumor", "malignant ocular tumour", "malignant tumor of eye", "malignant tumor of the eye", "malignant tumour of eye", "malignant tumour of the eye", "neoplasm of eye proper" ], "categories": [ { "ref": "MONDO:0002022", "name": "disorder of orbital region" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0024458", "name": "disorder of visual system" } ], "definition": "A benign or malignant neoplasm affecting the structures of the eye." }, "child_count": 30, "reference_id": "MONDO:0002236" }, { "id": 4519, "label": "malignant cranial nerve neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4684, 7266, 20329 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2815", "ICD9:192.0", "MEDGEN:57567", "NCIT:C3571", "SCTID:188307009", "UMLS:C0153644" ], "synonyms": [ "cancer of cranial nerve", "cranial nerve cancer", "cranial nerve neoplasm, malignant", "malignant cranial nerve neoplasm", "malignant cranial nerve tumor", "malignant cranial nerve tumour", "malignant neoplasm of cranial nerve", "malignant neoplasm of cranial nerves", "malignant neoplasm of the cranial nerve", "malignant tumor of cranial nerve", "malignant tumor of the cranial nerve", "malignant tumour of cranial nerve", "malignant tumour of the cranial nerve", "cranial nerve malignant neoplasm" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Abnormal malignant growth of the cells that comprise the cranial nerve." }, "child_count": 15, "reference_id": "MONDO:0002433" }, { "id": 5218, "label": "malignant ear neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 3050, 7266, 20443 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5101", "MEDGEN:418247", "MESH:D004428", "NCIT:C9337", "SCTID:443648003", "UMLS:C2350059" ], "synonyms": [ "cancer of ear", "ear cancer", "malignant Ear neoplasm", "malignant Ear tumor", "malignant Ear tumour", "malignant ear neoplasm", "malignant neoplasm of Ear", "malignant neoplasm of ear", "malignant neoplasm of the Ear", "malignant tumor of Ear", "malignant tumor of ear", "malignant tumor of the Ear", "malignant tumour of Ear", "malignant tumour of ear", "malignant tumour of the Ear", "auricular cancer" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A malignant neoplasm that affects the ear. Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear." }, "child_count": 9, "reference_id": "MONDO:0003277" }, { "id": 6418, "label": "tongue cancer", "isLeaf": false, "isRoot": false, "parents": [ 3050, 7170, 7266, 20449 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8649", "GARD:0027692", "ICD9:141", "ICD9:141.0", "ICD9:141.1", "ICD9:141.2", "ICD9:141.3", "ICD9:141.4", "ICD9:141.5", "ICD9:141.6", "ICD9:141.9", "MEDGEN:102262", "MESH:D014062", "NCIT:C9345", "SCTID:363360003", "UMLS:C0153349" ], "synonyms": [ "cancer of tongue", "malignant neoplasm of tongue", "malignant tongue neoplasm", "malignant tongue tumor", "malignant tongue tumour", "malignant tumor of the tongue", "malignant tumor of tongue", "malignant tumour of the tongue", "malignant tumour of tongue", "tongue cancer", "tongue neoplasm malignant", "tongue neoplasm, malignant", "malignant neoplasm of anterior 2/3 of tongue", "malignant neoplasm of anterior two-thirds of tongue", "malignant neoplasm of anterior two-thirds of tongue, part unspecified", "malignant neoplasm of base of tongue", "malignant neoplasm of border of tongue", "malignant neoplasm of dorsal surface of tongue", "malignant neoplasm of dorsal tongue", "malignant neoplasm of dorsal tongue NOS", "malignant neoplasm of dorsum of tongue", "malignant neoplasm of fixed part of tongue", "malignant neoplasm of fixed part of tongue NOS", "malignant neoplasm of junctional zone of tongue", "malignant neoplasm of mobile part of tongue", "malignant neoplasm of mobile part of tongue NOS", "malignant neoplasm of other sites of tongue", "malignant neoplasm of the tongue", "malignant neoplasm of tip and lateral border of tongue", "malignant neoplasm of tip and/or lateral border of tongue", "malignant neoplasm of tongue NOS", "malignant neoplasm of tongue, NOS", "malignant neoplasm of tongue, tip and lateral border", "malignant neoplasm of ventral surface of tongue", "malignant neoplasm of ventral tongue surface", "malignant tumor of anterior two-thirds of tongue", "malignant tumor of base of tongue", "malignant tumor of lingual tonsil", "malignant tumor of mobile part of tongue", "malignant tumor of posterior tongue", "malignant tumour of anterior two-thirds of tongue", "malignant tumour of base of tongue", "malignant tumour of lingual tonsil", "malignant tumour of mobile part of tongue", "malignant tumour of posterior tongue", "tongue neoplasm malignant stage unspecified", "malignant neoplasm of lingual tonsil", "malignant tumor of lingual tonsil (disorder)", "malignant tumour of lingual tonsil (disorder)", "tongue carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas." }, "child_count": 8, "reference_id": "MONDO:0004631" }, { "id": 6431, "label": "cheek mucosa cancer", "isLeaf": false, "isRoot": false, "parents": [ 7170, 7266, 20450 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8702", "ICD9:145.0", "MEDGEN:57550", "NCIT:C9320", "SCTID:363386008", "UMLS:C0153373" ], "synonyms": [ "buccal mucosa cancer", "cancer of buccal mucosa", "malignant buccal mucosa neoplasm", "malignant buccal mucosa tumor", "malignant buccal mucosa tumour", "malignant neoplasm of buccal mucosa", "malignant neoplasm of the buccal mucosa", "malignant tumor of buccal mucosa", "malignant tumor of the buccal mucosa", "malignant tumour of buccal mucosa", "malignant tumour of the buccal mucosa" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A malignant neoplasm involving the buccal mucosa." }, "child_count": 3, "reference_id": "MONDO:0004645" }, { "id": 6436, "label": "malignant carotid body paraganglioma", "isLeaf": true, "isRoot": false, "parents": [ 4753, 7266, 20296, 20310, 20329 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8731", "GARD:0024080", "ICD10CM:C75.4", "ICD9:194.5", "MEDGEN:56318", "NCIT:C3574", "SCTID:447883002", "UMLS:C0153656" ], "synonyms": [ "carotid body paraganglioma, malignant", "malignant carotid body paraganglioma", "malignant carotid body tumor (morphologic abnormality)", "malignant carotid body tumour (morphologic abnormality)", "carotid body cancer", "chemodectoma, malignant", "malignant carotid body neoplasm", "malignant carotid body tumor", "malignant carotid body tumour", "malignant neoplasm of carotid body", "malignant neoplasm of the carotid body", "malignant tumor of carotid body", "malignant tumor of the carotid body", "malignant tumour of carotid body", "malignant tumour of the carotid body" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A carotid body paraganglioma that metastasizes to other anatomic sites." }, "child_count": 0, "reference_id": "MONDO:0004650" }, { "id": 6453, "label": "salivary gland cancer", "isLeaf": false, "isRoot": false, "parents": [ 7170, 7266, 20523 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8850", "GARD:0027698", "ICD10CM:C08", "ICD9:142.8", "MEDGEN:65079", "MESH:D012468", "NCIT:C3811", "SCTID:255072001", "UMLS:C0220636" ], "synonyms": [ "cancer of saliva-secreting gland", "cancer of salivary gland", "cancer of the salivary gland", "malignant neoplasm of saliva-secreting gland", "malignant neoplasm of salivary gland", "malignant neoplasm of salivary gland duct", "malignant neoplasm of the salivary gland", "malignant saliva-secreting gland neoplasm", "malignant salivary gland neoplasm", "malignant salivary gland tumor", "malignant salivary gland tumour", "malignant tumor of salivary gland", "malignant tumor of the salivary gland", "malignant tumour of salivary gland", "malignant tumour of the salivary gland", "saliva-secreting gland cancer", "salivary gland cancer", "malignant neoplasm of major salivary gland", "malignant tumour of the major salivary gland" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A primary or metastatic malignant neoplasm that affects the major or minor salivary glands. Representative examples include carcinoma, lymphoma, and sarcoma." }, "child_count": 9, "reference_id": "MONDO:0004669" }, { "id": 6497, "label": "hard palate cancer", "isLeaf": false, "isRoot": false, "parents": [ 6981, 7170, 7266 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9149", "ICD10CM:C05.0", "ICD9:145.2", "MEDGEN:57551", "NCIT:C3528", "SCTID:363387004", "UMLS:C0153375" ], "synonyms": [ "cancer of hard palate", "hard palate", "hard palate cancer", "malignant hard palate neoplasm", "malignant hard palate tumor", "malignant hard palate tumour", "malignant neoplasm of hard palate", "malignant neoplasm of the hard palate", "malignant tumor of hard palate", "malignant tumor of the hard palate", "malignant tumour of the hard palate" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A malignant neoplasm involving the hard palate." }, "child_count": 3, "reference_id": "MONDO:0004719" }, { "id": 7163, "label": "gingival cancer", "isLeaf": false, "isRoot": false, "parents": [ 3041, 7170, 7266, 20327 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8602", "EFO:0005557", "GARD:0024198", "ICD10CM:C03", "ICD9:143", "ICD9:143.8", "ICD9:143.9", "MEDGEN:57549", "MedDRA:10067807", "NCIT:C9317", "SCTID:363382005", "UMLS:C0153364", "icd11.foundation:1719710858" ], "synonyms": [ "cancer of gingiva", "gingiva cancer", "malignant gingiva neoplasm", "malignant gingival neoplasm", "malignant gingival tumor", "malignant gingival tumour", "malignant gum neoplasm", "malignant gum tumor", "malignant gum tumour", "malignant neoplasm of gingiva", "malignant neoplasm of gum", "malignant neoplasm of the gingiva", "malignant neoplasm of the gum", "malignant tumor of gingiva", "malignant tumor of gum", "malignant tumor of the gingiva", "malignant tumor of the gum", "malignant tumour of gingiva", "malignant tumour of gum", "malignant tumour of the gingiva", "malignant tumour of the gum", "gum cancer" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A primary or metastatic malignant neoplasm that affects the gums." }, "child_count": 8, "reference_id": "MONDO:0005507" }, { "id": 8278, "label": "lip cancer", "isLeaf": false, "isRoot": false, "parents": [ 7170, 7266, 20457 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8564", "EFO:1001019", "GARD:0027767", "ICD10CM:C00", "ICD9:140", "ICD9:140.5", "ICD9:140.6", "ICD9:140.8", "MEDGEN:57548", "MESH:D008048", "MedDRA:10007089", "NCIT:C7485", "SCTID:187622006", "UMLS:C0153340", "icd11.foundation:304997495" ], "synonyms": [ "cancer of lip", "lip cancer", "malignant Lip neoplasm", "malignant Lip tumor", "malignant Lip tumour", "malignant lip neoplasm", "malignant neoplasm of Lip", "malignant neoplasm of lip", "malignant neoplasm of lip, inner aspect", "malignant neoplasm of lip, unspecified", "malignant neoplasm of lip, unspecified, inner aspect", "malignant neoplasm of lip, unspecified, vermilion border", "malignant neoplasm of oral aspect of lip, not specified whether upper or lower", "malignant neoplasm of the Lip", "malignant tumor of Lip", "malignant tumor of commissure of lip", "malignant tumor of labial commissure", "malignant tumor of lip", "malignant tumor of the Lip", "malignant tumour of Lip", "malignant tumour of commissure of lip", "malignant tumour of labial mucosa", "malignant tumour of lip", "malignant tumour of lower labial mucosa", "malignant tumour of the Lip" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the lip." }, "child_count": 9, "reference_id": "MONDO:0006834" }, { "id": 20492, "label": "malignant tumor of neck", "isLeaf": false, "isRoot": false, "parents": [ 7266, 20519 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:155434", "NCIT:C4940", "SCTID:363489000", "UMLS:C0746787" ], "synonyms": [ "cancer of neck", "cancer of the neck", "malignant neck neoplasm", "malignant neck tumor", "malignant neck tumour", "malignant neoplasm of neck", "malignant neoplasm of the neck", "malignant tumor of the neck", "malignant tumour of the neck", "neck cancer" ], "definition": "A cancer that involves the neck." }, "child_count": 2, "reference_id": "MONDO:0021310" }, { "id": 20499, "label": "malignant tumor of floor of mouth", "isLeaf": false, "isRoot": false, "parents": [ 4587, 7266, 20540 ], "type_id": 0, "properties": { "xrefs": [ "ICD10CM:C04", "ICD9:144.8", "ICD9:144.9", "MEDGEN:102264", "NCIT:C9318", "SCTID:363385007", "UMLS:C0153368", "icd11.foundation:359540510" ], "synonyms": [ "cancer of mouth floor", "malignant floor of mouth neoplasm", "malignant floor of mouth tumor", "malignant floor of mouth tumour", "malignant floor of the mouth neoplasm", "malignant floor of the mouth tumor", "malignant floor of the mouth tumour", "malignant mouth floor neoplasm", "malignant neoplasm of floor of mouth", "malignant neoplasm of mouth floor", "malignant neoplasm of the floor of the mouth", "malignant tumor of the floor of the mouth", "malignant tumour of the floor of the mouth", "mouth floor cancer" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A cancer that involves the mouth floor." }, "child_count": 3, "reference_id": "MONDO:0021320" }, { "id": 20861, "label": "angiosarcoma of the scalp", "isLeaf": true, "isRoot": false, "parents": [ 7266, 17394 ], "type_id": 0, "properties": { "synonyms": [ "angiosarcoma (disease) of scalp", "scalp angiosarcoma (disease)" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" } ], "definition": "Angiosarcoma of the scalp is a rare cancer which most commonly affects the elderly. This condition is characterized by bruise-like lesions that escalate to elevated, nodular, or ulcerated tumors. Extensive local growth is common and metastasis to regional lymph nodes and to the lungs may occur. The cause of angiosarcoma of the scalp is unknown, although several associations have been reported, including lymphedema, prior radiation treatment, and environmental exposures. Treatment may include surgery, radiation and chemotherapy." }, "child_count": 0, "reference_id": "MONDO:0022454" } ], "roots": [ { "id": 6733, "label": "cancer" }, { "id": 7231, "label": "head and neck neoplasm" } ] }