{
  "id": 7383,
  "label": "Flaviviridae infectious disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005763",
  "properties": {
    "xrefs": [
      "EFO:0007274",
      "MESH:D018178",
      "SCTID:111865007"
    ],
    "synonyms": [
      "Flaviviridae caused disease or disorder",
      "Flaviviridae disease or disorder"
    ],
    "definition": "Infections with viruses of the family flaviviridae."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 24062,
      "label": "primary viral infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6834
      ],
      "type_id": 0,
      "properties": {
        "definition": "The initial viral infectious disase that causes illness."
      },
      "child_count": 32,
      "reference_id": "MONDO:0100329"
    }
  ],
  "children": [
    {
      "id": 2812,
      "label": "Powassan encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        7600,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050179",
          "GARD:0022741",
          "ICD9:063.8",
          "MEDGEN:18601",
          "SCTID:416707008",
          "UMLS:C0032858",
          "icd11.foundation:1674038791"
        ],
        "synonyms": [
          "Powassan virus caused disease or disorder",
          "Powassan virus disease or disorder",
          "Powassan virus infectious disease",
          "powassan encephalitis virus infection",
          "encephalitis, powassan"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease caused by infection with Powassan virus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000276"
    },
    {
      "id": 3383,
      "label": "Murray valley encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10842",
          "ICD10CM:A83.4",
          "ICD9:062.4",
          "MEDGEN:509134",
          "SCTID:66454007",
          "UMLS:C0153066",
          "icd11.foundation:1040970454"
        ],
        "synonyms": [
          "Australian X disease",
          "Australian encephalitis",
          "Murray Valley encephalitis virus caused disease or disorder",
          "Murray Valley encephalitis virus disease or disorder",
          "Murray Valley encephalitis virus infectious disease"
        ],
        "definition": "An disease caused by infection with Murray Valley encephalitis virus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001137"
    },
    {
      "id": 4396,
      "label": "West Nile fever",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7383,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2366",
          "ICD10CM:A92.3",
          "ICD9:066.4",
          "ICD9:066.40",
          "MEDGEN:22705",
          "MESH:D014901",
          "SCTID:417093003",
          "UMLS:C0043124"
        ],
        "synonyms": [
          "West Nile virus caused disease or disorder",
          "West Nile virus disease or disorder",
          "West Nile virus infectious disease"
        ],
        "definition": "A mosquito-borne viral illness caused by the west nile virus, a flavivirus and endemic to regions of Africa, Asia, and Europe. Common clinical features include headache; fever; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. meningitis; encephalitis; and myelitis may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)"
      },
      "child_count": 2,
      "reference_id": "MONDO:0002282"
    },
    {
      "id": 7158,
      "label": "dengue disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7383,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12205",
          "EFO:0005547",
          "GARD:0006254",
          "ICD10CM:A90",
          "ICD9:061",
          "MEDGEN:3721",
          "MESH:D003715",
          "MedDRA:10012310",
          "NCIT:C34528",
          "Orphanet:99828",
          "SCTID:38362002",
          "UMLS:C0011311"
        ],
        "synonyms": [
          "DF",
          "Dengue",
          "Dengue fever",
          "Dengue virus caused disease or disorder",
          "Dengue virus disease or disorder",
          "Dengue virus infection",
          "Dengue virus infectious disease",
          "break bone fever",
          "Philippine hemorrhagic fever",
          "Singapore hemorrhagic fever",
          "Thai hemorrhagic fever",
          "hemorrhagic dengue"
        ],
        "definition": "Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005502"
    },
    {
      "id": 7511,
      "label": "pestivirus infectious disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007432",
          "MEDGEN:60191",
          "MESH:D018182",
          "UMLS:C0206611"
        ],
        "synonyms": [
          "Pestivirus caused disease or disorder",
          "Pestivirus disease or disorder",
          "Pestivirus infectious disease",
          "Pestivirus infection",
          "infection, Pestivirus",
          "infections, Pestivirus"
        ],
        "definition": "Infections with viruses of the genus pestivirus, family flaviviridae."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005909"
    },
    {
      "id": 7561,
      "label": "st. Louis encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        20036
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10845",
          "EFO:0007495",
          "GARD:0019041",
          "ICD10CM:A83.3",
          "ICD9:062.3",
          "MEDGEN:41773",
          "MESH:D004674",
          "MedDRA:10041896",
          "Orphanet:83484",
          "SCTID:417607009",
          "UMLS:C0014060",
          "icd11.foundation:1306878274"
        ],
        "synonyms": [
          "Neuroinvasive St. Louis encephalitis virus infection",
          "Saint Louis encephalitis",
          "St. Louis encephalitis virus caused infectious encephalitis",
          "St. Louis encephalitis virus infectious encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A viral encephalitis caused by the St. Louis encephalitis virus (encephalitis virus, st. louis), a flavivirus. It is transmitted to humans and other vertebrates primarily by mosquitoes of the genus culex. The primary animal vectors are wild birds and the disorder is endemic to the midwestern and southeastern United States. Infections may be limited to an influenza-like illness or present as an aseptic meningitis or encephalitis. Clinical manifestations of the encephalitic presentation may include seizures, lethargy, myoclonus, focal neurologic signs, coma, and death. (From Adams et al., Principles of Neurology, 6th ed, p750)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005969"
    },
    {
      "id": 18095,
      "label": "Kyasanur forest disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7383,
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11320",
          "GARD:0008257",
          "ICD10CM:A98.2",
          "ICD9:065.2",
          "MEDGEN:5982",
          "MESH:D007733",
          "MedDRA:10023505",
          "Orphanet:319254",
          "SCTID:23097003",
          "UMLS:C0022810",
          "icd11.foundation:1288604967"
        ],
        "synonyms": [
          "Kyasanur forest disease virus caused disease or disorder",
          "Kyasanur forest disease virus disease or disorder",
          "Kyasanur forest disease virus infectious disease",
          "Kyasanur hemorrhagic fever",
          "KFD",
          "KFD virus",
          "monkey disease",
          "monkey fever"
        ],
        "definition": "Kyasanura forest disease (KFD), caused by the KFD virus, is an arbovirus characterized by an initial fever, headache and myalgia that can progress to a hemorrhagic disease and that in some cases is followed by a second phase characterized by neurological manifestations."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017881"
    },
    {
      "id": 18096,
      "label": "Omsk hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        18247,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:992",
          "GARD:0008254",
          "ICD10CM:A98.1",
          "ICD9:065.1",
          "MEDGEN:9212",
          "MESH:D006481",
          "MedDRA:10030310",
          "Orphanet:319266",
          "SCTID:48113006",
          "UMLS:C0019103",
          "icd11.foundation:946068954"
        ],
        "definition": "Omsk hemorrhagic fever (OHF), caused by Omsk hemorrhagic fever virus (OHFV), is a zoonotic disease characterized by fever, nausea, myalgia and moderately severe hemorrhagic manifestations as well as in some cases meningitis, pneumonia and nephrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017882"
    },
    {
      "id": 18653,
      "label": "Zika virus infectious disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060478",
          "GARD:0012894",
          "ICD10CM:A92.5",
          "MEDGEN:547236",
          "MESH:D000071243",
          "NCIT:C128423",
          "Orphanet:448237",
          "SCTID:3928002",
          "UMLS:C0276289",
          "icd11.foundation:1401438580"
        ],
        "synonyms": [
          "ZikV infection",
          "Zika",
          "Zika virus caused disease or disorder",
          "Zika virus disease",
          "Zika virus disease or disorder",
          "Zika virus infection",
          "Zika virus infectious disease",
          "congenital Zika syndrome",
          "congenital Zika virus infection",
          "Zika fever",
          "fever, Zika"
        ],
        "definition": "Mosquito-born virus disease characterized by a clinical course that may be asymptomatic or mild with fever, conjunctivitis, muscle and joint pain, headache, exanthema, but may also be associated with severe neurological (meningitis, meningoencephalitis and myelitis) and auto-immune (Guillain-Barre syndrome) complications, as well as a potential increase of birth defects (microcephaly) if the infection occurs during pregnancy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018661"
    },
    {
      "id": 19955,
      "label": "yellow fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        18253,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9682",
          "GARD:0007914",
          "ICD10CM:A95",
          "ICD10WHO:A95",
          "ICD9:060",
          "ICD9:060.9",
          "MEDGEN:53112",
          "MESH:D015004",
          "MedDRA:10048240",
          "NCIT:C35547",
          "NORD:1873",
          "Orphanet:99829",
          "UMLS:C0043395",
          "icd11.foundation:383352795"
        ],
        "synonyms": [
          "YF",
          "Yellow Jack",
          "Yellow fever Virus infection",
          "Yellow fever virus caused disease or disorder",
          "Yellow fever virus disease or disorder",
          "Yellow fever virus infectious disease",
          "bronze John",
          "sylvatic yellow fever"
        ],
        "definition": "Yellow fever (YF), caused by YF virus, is a zoonotic disease characterized by fever and constitutional symptoms, with the potential to progress to severe and fatal viral hemorrhagic fever with shock and multi-organ system failure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020502"
    }
  ],
  "roots": [
    {
      "id": 24062,
      "label": "primary viral infectious disease"
    }
  ]
}