{
  "id": 7431,
  "label": "pancreatic neuroendocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005815",
  "properties": {
    "xrefs": [
      "DOID:1799",
      "EFO:0007331",
      "GARD:0022052",
      "ICDO:8150/1",
      "MEDGEN:1848937",
      "NCIT:C27031",
      "Orphanet:506052",
      "SCTID:254611009",
      "UMLS:C5848399",
      "icd11.foundation:1421495979"
    ],
    "synonyms": [
      "PNEN",
      "endocrine pancreas neoplasm",
      "endocrine pancreas neoplasm (disease)",
      "endocrine pancreas tumor",
      "endocrine pancreas tumour",
      "neoplasm of endocrine pancreas",
      "pancreatic NEN",
      "pancreatic endocrine neoplasm",
      "pancreatic neuroendocrine neoplasm",
      "tumor of endocrine pancreas",
      "tumour of endocrine pancreas",
      "Islet cell tumors",
      "Islet cell tumours",
      "endocrine pancreas cancer",
      "islet cell neoplasm",
      "islet cell tumor",
      "islet cell tumour",
      "malignant pancreatic endocrine tumor",
      "malignant pancreatic endocrine tumour",
      "Islet of Langerhans tumor",
      "Islet of Langerhans tumour",
      "neuroendocrine neoplasm of pancreas"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neoplasm with neuroendocrine differentiation that arises from the pancreas. It includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine carcinomas (high grade)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4104,
      "label": "endocrine pancreas disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4455
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1428",
          "ICD9:251",
          "MEDGEN:124407",
          "NCIT:C27067",
          "SCTID:17346000",
          "UMLS:C0271633"
        ],
        "synonyms": [
          "disease of endocrine pancreas",
          "disease or disorder of endocrine pancreas",
          "disorder of endocrine pancreas",
          "endocrine pancreas disease",
          "endocrine pancreas disease or disorder",
          "endocrine pancreas disorder",
          "disorder of islets of langerhans",
          "disorder of pancreatic islets"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the endocrine pancreas."
      },
      "child_count": 12,
      "reference_id": "MONDO:0001933"
    },
    {
      "id": 20285,
      "label": "pancreatic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4455,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003860",
          "MEDGEN:18279",
          "MESH:D010190",
          "NCIT:C3305",
          "ONCOTREE:PANCREAS",
          "SCTID:126859007",
          "UMLS:C0030297"
        ],
        "synonyms": [
          "neoplasm of pancreas",
          "neoplasm of the pancreas",
          "pancreas neoplasm",
          "pancreas neoplasm (disease)",
          "pancreas tumor",
          "pancreas tumour",
          "pancreatic neoplasm",
          "pancreatic tumor",
          "pancreatic tumour",
          "tumor of pancreas",
          "tumor of the pancreas",
          "tumour of pancreas",
          "tumour of the pancreas",
          "pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm involving the pancreas."
      },
      "child_count": 14,
      "reference_id": "MONDO:0021040"
    },
    {
      "id": 21456,
      "label": "digestive system neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        19314,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002437",
          "MEDGEN:232237",
          "MESH:C535650",
          "NCIT:C27721",
          "Orphanet:100092",
          "UMLS:C1333799"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system NET",
          "alimentary part of gastrointestinal system neuroendocrine neoplasm",
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumor, well differentiated, low or intermediate grade",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "carcinoid tumor of digestive system",
          "carcinoid tumour of digestive system",
          "digestive system NET",
          "digestive system neuroendocrine neoplasm",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumor, well differentiated, low or intermediate grade",
          "digestive system neuroendocrine tumour",
          "gastro-enteropancreatic neuroendocrine tumor",
          "gastro-enteropancreatic neuroendocrine tumour",
          "gastroenteropancreatic endocrine tumor",
          "gastroenteropancreatic endocrine tumour",
          "gastroenteropancreatic neuroendocrine neoplasm",
          "gastrointestinal neuroendocrine neoplasm",
          "gastrointestinal system neuroendocrine neoplasm",
          "neuroendocrine neoplasm of alimentary part of gastrointestinal system",
          "neuroendocrine neoplasm of digestive system",
          "GEP tumors",
          "GEP tumours",
          "GEP-NEN",
          "GEP-NET",
          "carcinoid tumor",
          "carcinoid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas)."
      },
      "child_count": 21,
      "reference_id": "MONDO:0024503"
    }
  ],
  "children": [
    {
      "id": 7497,
      "label": "pancreatic endocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        7431,
        7738,
        11035
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1798",
          "EFO:0007416",
          "GARD:0022056",
          "ICD10CM:C25.4",
          "ICD9:157.4",
          "ICDO:8150/3",
          "MEDGEN:233070",
          "MESH:D018273",
          "NCIT:C3770",
          "Orphanet:506098",
          "SCTID:254612002",
          "UMLS:C1328479"
        ],
        "synonyms": [
          "Pancreatic Neuroendocrine cancer",
          "carcinoma of endocrine pancreas",
          "carcinoma, islet cell, malignant",
          "endocrine pancreas carcinoma",
          "high grade pancreatic neuroendocrine carcinoma",
          "high-grade pancreatic neuroendocrine carcinoma",
          "islet cell cancer",
          "islet cell carcinoma",
          "islet cell carcinoma (morphologic abnormality)",
          "malignant islet cell tumor",
          "malignant islet cell tumour",
          "malignant neoplasm of islets of Langerhans",
          "malignant pancreatic endocrine tumor",
          "malignant pancreatic endocrine tumour",
          "pancreatic NEC",
          "pancreatic NEC G3",
          "pancreatic endocrine cancer",
          "pancreatic endocrine carcinoma",
          "pancreatic neuroendocrine carcinoma",
          "poorly differentiated pancreatic endocrine carcinoma",
          "poorly-differentiated NEN of pancreas",
          "poorly-differentiated neuroendocrine neoplasm of pancreas",
          "poorly-differentiated pancreatic NEN",
          "poorly-differentiated pancreatic neuroendocrine neoplasm",
          "neuroendocrine carcinoma of pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005893"
    },
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        7431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000045",
          "GARD:0013034",
          "ICDO:8150/1",
          "MEDGEN:277875",
          "NCIT:C27720",
          "ONCOTREE:PANET",
          "Orphanet:97253",
          "UMLS:C1337011"
        ],
        "synonyms": [
          "islet cell tumor",
          "islet cell tumors - pancreas",
          "islet cell tumors of the pancreas",
          "islet cell tumour",
          "islet cell tumours - pancreas",
          "islet cell tumours of the pancreas",
          "pancreatic NET",
          "pancreatic neuroendocrine tumor",
          "well differentiated pancreatic endocrine neoplasm",
          "well differentiated pancreatic endocrine tumor",
          "well differentiated pancreatic endocrine tumour",
          "well-differentiated NEN of pancreas",
          "well-differentiated neuroendocrine neoplasm of pancreas",
          "well-differentiated pancreatic NEN",
          "well-differentiated pancreatic neuroendocrine neoplasm",
          "PANET",
          "neuroendocrine tumor of pancreas",
          "neuroendocrine tumour of pancreas",
          "pancreatic endocrine tumor",
          "pancreatic endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma)."
      },
      "child_count": 22,
      "reference_id": "MONDO:0019954"
    }
  ],
  "roots": [
    {
      "id": 4104,
      "label": "endocrine pancreas disorder"
    },
    {
      "id": 20285,
      "label": "pancreatic neoplasm"
    },
    {
      "id": 21456,
      "label": "digestive system neuroendocrine neoplasm"
    }
  ]
}