{
  "id": 7447,
  "label": "lymphatic system disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005833",
  "properties": {
    "xrefs": [
      "DOID:75",
      "EFO:0007352",
      "MEDGEN:892707",
      "MESH:D008206",
      "NCIT:C50764",
      "SCTID:362971004",
      "UMLS:C4021976"
    ],
    "synonyms": [
      "disease of lymphatic part of lymphoid system",
      "disease or disorder of lymphatic part of lymphoid system",
      "disorder of lymphatic part of lymphoid system",
      "glands, swollen",
      "lymphatic disease",
      "lymphatic part of lymphoid system disease",
      "lymphatic part of lymphoid system disease or disorder",
      "swollen gland",
      "swollen glands",
      "lymphadenopathy",
      "lymphangiopathy",
      "adenopathy",
      "disease of lympoid system",
      "disorder of lymphoid system",
      "lympoid system disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A disease involving the lymphatic part of lymphoid system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 14,
  "parents": [
    {
      "id": 23494,
      "label": "lymphoid system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:9829",
          "SCTID:111590001",
          "UMLS:C0024228"
        ],
        "synonyms": [
          "disease of lymphoid system",
          "disease or disorder of lymphoid system",
          "disorder of lymphoid system",
          "lymphoid system disease",
          "lymphoid system disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disease or disorder that involves the lymphoid system."
      },
      "child_count": 5,
      "reference_id": "MONDO:0044986"
    }
  ],
  "children": [
    {
      "id": 3023,
      "label": "lymphatic system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060073"
        ],
        "synonyms": [
          "cancer of lymphatic part of lymphoid system",
          "lymphatic part of lymphoid system cancer",
          "malignant lymphatic part of lymphoid system neoplasm",
          "malignant neoplasm of lymphatic part of lymphoid system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the lymphatic part of lymphoid system"
      },
      "child_count": 8,
      "reference_id": "MONDO:0000612"
    },
    {
      "id": 3360,
      "label": "bubonic plague",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7447,
        18984
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10773",
          "GARD:0000183",
          "ICD10CM:A20.0",
          "ICD9:020.0",
          "MEDGEN:76407",
          "SCTID:50797007",
          "UMLS:C0282312",
          "icd11.foundation:1742025109"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A plague in which the bacteria have infected the lymphatic system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001112"
    },
    {
      "id": 4438,
      "label": "splenic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217,
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2529",
          "EFO:0009002",
          "ICD10CM:D73",
          "ICD9:289.50",
          "MEDGEN:21291",
          "MESH:D013158",
          "NCIT:C35823",
          "SCTID:51244008",
          "UMLS:C0037997"
        ],
        "synonyms": [
          "disease of spleen",
          "disease or disorder of spleen",
          "disorder of spleen",
          "spleen disease",
          "spleen disease or disorder",
          "spleen disorder",
          "splenic disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease involving the spleen."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002332"
    },
    {
      "id": 4688,
      "label": "histiocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3405",
          "MEDGEN:6845",
          "MESH:D015614",
          "NANDO:2100005",
          "NCIT:C3106",
          "ONCOTREE:HDCN",
          "UMLS:C0019618"
        ],
        "synonyms": [
          "histiocytic infiltrate",
          "histiocytic syndrome",
          "histiocytic and dendritic cell neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes."
      },
      "child_count": 5,
      "reference_id": "MONDO:0002637"
    },
    {
      "id": 4972,
      "label": "lymphocele",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4347",
          "ICD9:457.8",
          "MEDGEN:7414",
          "MESH:D008210",
          "SCTID:234110002",
          "UMLS:C0024248",
          "icd11.foundation:1806199285"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A cystic lesion containing lymph. It usually results from injury, gynecologic surgery, or urologic surgery."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002968"
    },
    {
      "id": 6675,
      "label": "lymph node disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9942",
          "MEDGEN:78802",
          "NCIT:C35346",
          "SCTID:76616003",
          "UMLS:C0272394"
        ],
        "synonyms": [
          "disease of lymph node",
          "disease or disorder of lymph node",
          "disorder of lymph node",
          "lymph node disease",
          "lymph node disease or disorder",
          "lymph node disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Any disorder of the lymph nodes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004928"
    },
    {
      "id": 7446,
      "label": "lymphangitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7447,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9317",
          "EFO:0007351",
          "GARD:0024239",
          "ICD10CM:I89.1",
          "ICD9:457.2",
          "MEDGEN:7412",
          "MESH:D008205",
          "NCIT:C34790",
          "SCTID:1415005",
          "UMLS:C0024225",
          "icd11.foundation:1548743622"
        ],
        "synonyms": [
          "inflammation of lymphatic vessel",
          "lymphatic vessel inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Inflammation of the lymphatic vessels."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005832"
    },
    {
      "id": 7448,
      "label": "lymphogranuloma venereum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7332,
        7397,
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13819",
          "EFO:0007353",
          "ICD10CM:A55",
          "ICD9:099.1",
          "MEDGEN:44221",
          "MESH:D008219",
          "NCIT:C26822",
          "SCTID:186946009",
          "UMLS:C0024286"
        ],
        "synonyms": [
          "Durand-Nicolas-Favre disease",
          "climatic or tropical bubo",
          "lymph granuloma inguinale",
          "lymphogranuloma inguinale",
          "LGV"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Infection with the organism Mycobacterium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005834"
    },
    {
      "id": 8284,
      "label": "lymphangiectasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7447,
        20710
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001025",
          "MEDGEN:9827",
          "MESH:D008200",
          "NCIT:C97087",
          "UMLS:C0024214"
        ],
        "synonyms": [
          "lymphangiectasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Dilatation of the lymphatic vessels."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006840"
    },
    {
      "id": 16354,
      "label": "hemophagocytic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050120",
          "GARD:0020024",
          "ICD10CM:D76.1",
          "ICD9:288.8",
          "MEDGEN:854411",
          "MedDRA:10058125",
          "NANDO:2200032",
          "NCIT:C34792",
          "NCIT:C35439",
          "NORD:1938",
          "Orphanet:158032",
          "SCTID:234437005",
          "UMLS:C3887558"
        ],
        "synonyms": [
          "HLH",
          "Hemophagocytic Lymphohistiocytosis",
          "hemophagocytic lymphohistiocytosis",
          "hemophagocytic syndrome",
          "FHL",
          "familial erythrophagocytic lymphohistiocytosis",
          "familial hemophagocytic lymphohistiocytosis",
          "familial histiocytic reticulosis",
          "haemophagocytic syndrome",
          "hemophagocytic disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Hemophagocytic syndrome (HPS) is a rare immune disease and a potentially life-threatening disorder characterized by cytokine storm and overwhelming inflammation causing fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia, and hemophagocytosis in bone marrow, liver, spleen or lymph nodes. It can be either primary due to a genetic defect (primary hemophagocytic lymphohistiocytosis), or secondary to malignancies, to infections, most commonly with viruses such as Epstein-Barr virus or cytomegalovirus, human immunodeficiency virus, or to autoimmune disorders such as systemic lupus erythematosus or adult-onset Still disease (secondary hemophagocytic lymphohistiocytosis)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015540"
    },
    {
      "id": 18600,
      "label": "plastic bronchitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6815,
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021835",
          "MEDGEN:538495",
          "Orphanet:439881",
          "SCTID:53926002",
          "UMLS:C0264342"
        ],
        "synonyms": [
          "croupous bronchitis",
          "fibrinous bronchitis",
          "pseudo-membranous bronchitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lymphatic flow disorder that causes severe respiratory issues. In children with plastic bronchitis, lymph fluid builds in the airways and forms rubbery or caulk-like plugs (known as casts). These casts block the airways, making it difficult to breathe."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018597"
    },
    {
      "id": 19145,
      "label": "lymphedema",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4977",
          "ICD9:457.1",
          "MEDGEN:6155",
          "MESH:D008209",
          "MedDRA:10025282",
          "NCIT:C3207",
          "Orphanet:79383",
          "SCTID:234097001",
          "UMLS:C0024236"
        ],
        "synonyms": [
          "lymphatic edema (morphologic abnormality)",
          "lymphatic oedema",
          "lymphatic oedema (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Excess fluid collection in tissues, causing swelling. It is the result of obstruction of lymphatic vessels or lymph nodes."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019297"
    },
    {
      "id": 22949,
      "label": "lymphatic vessel neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065,
        7447,
        21330
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1857625",
          "NCIT:C3723",
          "UMLS:C2103272"
        ],
        "synonyms": [
          "lymph vessel neoplasm",
          "lymph vessel tumor",
          "lymph vessel tumour",
          "lymphatic vessel neoplasm",
          "lymphatic vessel tumor",
          "lymphatic vessel tumour",
          "neoplasm of lymph vessel",
          "neoplasm of lymphatic vessel",
          "neoplasm of the lymph vessel",
          "neoplasm of the lymphatic vessel",
          "tumor of lymph vessel",
          "tumor of lymphatic vessel",
          "tumor of the lymph vessel",
          "tumor of the lymphatic vessel",
          "tumour of lymph vessel",
          "tumour of lymphatic vessel",
          "tumour of the lymph vessel",
          "tumour of the lymphatic vessel"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the lymphatic vessels."
      },
      "child_count": 3,
      "reference_id": "MONDO:0036870"
    },
    {
      "id": 23265,
      "label": "pseudolymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001831",
          "MEDGEN:67450",
          "MESH:D019310",
          "NCIT:C3825",
          "SCTID:19750001",
          "UMLS:C0221269"
        ],
        "synonyms": [
          "pseudolymphoma",
          "benign lymphoid hyperplasia",
          "hyperplasia, reactive lymphoid",
          "hyperplasias, reactive lymphoid",
          "lymphocytoma",
          "lymphocytomas",
          "lymphoid Hyperplasias, reactive",
          "lymphoid hyperplasia, reactive",
          "pseudolymphomas",
          "reactive lymphoid Hyperplasias",
          "reactive lymphoid hyperplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A neoplastic process that resembles a malignant lymphoma, but has a benign course."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043959"
    }
  ],
  "roots": [
    {
      "id": 23494,
      "label": "lymphoid system disorder"
    }
  ]
}