{ "id": 7464, "label": "malignant mixed neoplasm", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0005853", "properties": { "xrefs": [ "DOID:154", "EFO:1000356", "ICDO:8940/3", "MEDGEN:64618", "MESH:D018198", "NCIT:C3729", "UMLS:C0206625" ], "synonyms": [ "mixed cell type cancer", "mixed neoplasm", "mixed tumor", "mixed tumour", "malignant mixed neoplasm", "malignant mixed tumor", "malignant mixed tumour", "mixed neoplasm, malignant", "mixed tumor, malignant (morphologic abnormality)", "mixed tumor, malignant, NOS (morphologic abnormality)", "tumor, mixed, malignant", "malignant mixed tumors", "malignant mixed tumours", "mixed tumors, malignant", "tumor, malignant mixed", "tumors, malignant mixed" ], "definition": "A malignant neoplasm composed of a carcinomatous epithelial component and a sarcomatous mesenchymal component. Representative examples include malignant mixed mesodermal (Mullerian) tumor of the female reproductive system and carcinosarcoma of the salivary gland and the lung." }, "isLeaf": false, "isRoot": false, "child_count": 15, "parents": [ { "id": 6733, "label": "cancer", "isLeaf": false, "isRoot": false, "parents": [ 6798 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050686", "DOID:0050687", "DOID:162", "ICD9:195.8", "ICD9:199", "ICD9:199.1", "ICDO:8000/3", "MEDGEN:14297", "NCIT:C9305", "ONCOTREE:MT", "SCTID:363346000", "UMLS:C0006826", "birnlex:406" ], "synonyms": [ "CA", "cancer", "cell type cancer", "malignancy", "malignant growth", "malignant neoplasm", "malignant neoplasm (disease)", "malignant neoplastic disease", "malignant tumor", "malignant tumour", "neoplasm (disease), malignant", "neoplasm, malignant", "MT" ], "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas." }, "child_count": 33, "reference_id": "MONDO:0004992" }, { "id": 20288, "label": "mixed neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6798 ], "type_id": 0, "properties": { "xrefs": [ "ICDO:8940/1", "MEDGEN:234575", "MESH:D018193", "NCIT:C6930", "UMLS:C1368354" ], "synonyms": [ "mixed neoplasm", "mixed tumor", "mixed tumour" ], "definition": "A neoplasm composed of at least two distinct cellular populations." }, "child_count": 10, "reference_id": "MONDO:0021043" } ], "children": [ { "id": 4552, "label": "carcinoma ex pleomorphic adenoma", "isLeaf": false, "isRoot": false, "parents": [ 4477, 6734, 7464 ], "type_id": 0, "properties": { "xrefs": [ "ICDO:8941/3", "MEDGEN:87486", "NCIT:C4397", "UMLS:C0344460" ], "synonyms": [ "carcinoma ex pleomorphic adenoma", "carcinoma ex pleomorphic adenoma (morphologic abnormality)", "carcinoma in pleomorphic adenoma" ], "definition": "A carcinoma arising in a pre-existing pleomorphic adenoma. It most often occurs in the parotid gland and less often in the submandibular gland and minor salivary gland. Patients usually present with a history of a long-standing mass which recently had undergone rapid growth. The prognosis depends on the invasiveness of the malignant component. Patients with non-invasive or minimally invasive tumors usually have a good prognosis following surgical resection. Invasive tumors are usually aggressive and are associated with recurrences and metastases." }, "child_count": 6, "reference_id": "MONDO:0002472" }, { "id": 4892, "label": "uterine body mixed cancer", "isLeaf": false, "isRoot": false, "parents": [ 7464, 7594, 16821 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4114", "GARD:0023285", "MEDGEN:233163", "NCIT:C6311", "UMLS:C1334628" ], "synonyms": [ "malignant body of uterus mixed neoplasm", "malignant body of uterus mixed tumor", "malignant body of uterus mixed tumour", "malignant corpus uteri mixed neoplasm", "malignant corpus uteri mixed tumor", "malignant corpus uteri mixed tumour", "malignant mixed neoplasm of body of uterus", "malignant mixed neoplasm of corpus uteri", "malignant mixed neoplasm of the body of uterus", "malignant mixed neoplasm of the corpus uteri", "malignant mixed neoplasm of the uterine body", "malignant mixed neoplasm of the uterine corpus", "malignant mixed neoplasm of uterine body", "malignant mixed neoplasm of uterine corpus", "malignant mixed tumor of body of uterus", "malignant mixed tumor of corpus uteri", "malignant mixed tumor of the body of uterus", "malignant mixed tumor of the corpus uteri", "malignant mixed tumor of the uterine body", "malignant mixed tumor of the uterine corpus", "malignant mixed tumor of uterine body", "malignant mixed tumor of uterine corpus", "malignant mixed tumour of body of uterus", "malignant mixed tumour of corpus uteri", "malignant mixed tumour of the body of uterus", "malignant mixed tumour of the corpus uteri", "malignant mixed tumour of the uterine body", "malignant mixed tumour of the uterine corpus", "malignant mixed tumour of uterine body", "malignant mixed tumour of uterine corpus", "malignant uterine body mixed neoplasm", "malignant uterine body mixed tumor", "malignant uterine body mixed tumour", "malignant uterine corpus mixed epithelial and mesenchymal neoplasm", "malignant uterine corpus mixed tumor", "malignant uterine corpus mixed tumour" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A primary malignant neoplasm of the uterine corpus characterized by the presence of an epithelial and a mesenchymal component. This category includes carcinosarcoma, carcinofibroma, and adenosarcoma." }, "child_count": 12, "reference_id": "MONDO:0002879" }, { "id": 4934, "label": "carcinosarcoma", "isLeaf": false, "isRoot": false, "parents": [ 7464 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4236", "GARD:0006966", "ICDO:8980/3", "MEDGEN:2876", "MESH:D002296", "NCIT:C34448", "UMLS:C0007140" ], "synonyms": [ "carcinosarcoma", "carcinosarcoma, malignant", "malignant mixed Mullerian tumour", "malignant mixed mesodermal (mullerian) tumour", "mesodermal mixed tumor (morphologic abnormality)", "mesodermal mixed tumour", "mesodermal mixed tumour (morphologic abnormality)", "mixed mesodermal (mullerian) tumour", "mullerian mixed tumor (morphologic abnormality)", "mullerian mixed tumour", "mullerian mixed tumour (morphologic abnormality)", "mixed Mullerian tumor", "mixed Mullerian tumour", "mixed tumor, Mullerian" ], "definition": "A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements." }, "child_count": 3, "reference_id": "MONDO:0002928" }, { "id": 4991, "label": "adenocarcinofibroma", "isLeaf": false, "isRoot": false, "parents": [ 3637, 7464 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4422", "MEDGEN:266966", "NCIT:C40035", "UMLS:C1510778" ], "synonyms": [ "adenocarcinofibroma", "adenofibroma, malignant", "malignant adenofibroma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma arising from the ovary. It is characterized by the presence of malignant epithelial cells in a fibrotic stroma. Histologic variants include clear cell, serous, mucinous, and endometrioid adenocarcinofibroma." }, "child_count": 6, "reference_id": "MONDO:0002991" }, { "id": 5875, "label": "ovarian seromucinous carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 5684, 6864, 7464 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6898", "DOID:6899", "GARD:0023786", "MEDGEN:1651770", "NCIT:C40090", "ONCOTREE:MXOV", "ONCOTREE:OSMCA", "UMLS:C0279392" ], "synonyms": [ "malignant ovarian mixed epithelial neoplasm", "malignant ovarian mixed epithelial tumor", "malignant ovarian mixed epithelial tumour", "mixed epithelial carcinoma of the ovary", "ovarian Seromucinous carcinoma", "ovarian mixed epithelial carcinoma", "ovary mixed epithelial carcinoma", "mixed ovarian carcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A malignant mixed epithelial neoplasm that arises from the ovary and is composed predominantly of serous and endocervical-type mucinous epithelium." }, "child_count": 0, "reference_id": "MONDO:0004032" }, { "id": 7274, "label": "adenosarcoma", "isLeaf": false, "isRoot": false, "parents": [ 3637, 7464 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1974", "EFO:0007134", "ICDO:8933/3", "MEDGEN:126", "MESH:D018195", "NCIT:C9474", "UMLS:C0001442" ], "synonyms": [ "Mullerian adenosarcoma", "Müllerian adenosarcoma", "adenosarcoma", "adenosarcoma (morphologic abnormality)", "mullerian adenosarcoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A low grade malignant neoplasm characterized by the presence of a benign epithelial component (tubular and cleft-like glands) and a low grade sarcomatous component that contains varying amounts of fibrous and smooth muscle tissues. In a minority of cases, the sarcomatous component contains heterologous elements including striated muscle, cartilage, and fat. It occurs in the uterine corpus, ovary, fallopian tube, cervix, and vagina. It may recur and in a minority of cases may metastasize to distant anatomic sites." }, "child_count": 10, "reference_id": "MONDO:0005636" }, { "id": 7641, "label": "Wilms tumor", "isLeaf": false, "isRoot": false, "parents": [ 7212, 7464 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0027737", "MEDGEN:10221", "MESH:D009396", "NCIT:C3267", "UMLS:C0027708" ], "synonyms": [ "Wilms tumor", "Wilms' tumor", "Wilms' tumour", "Wilms tumor (nephroblastoma)", "Wilms tumour (nephroblastoma)" ], "definition": "An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix." }, "child_count": 8, "reference_id": "MONDO:0006058" }, { "id": 7728, "label": "combined lung carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4255, 6862, 7117, 7464 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000200", "GARD:0024316", "MEDGEN:234166", "NCIT:C7591", "UMLS:C1333123" ], "synonyms": [ "combined carcinoma of lung", "combined carcinoma of the lung", "combined lung cancer", "combined lung carcinoma" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A lung carcinoma characterized by the presence of large or small neuroendocrine carcinoma cells in combination with malignant glandular or squamous epithelial cells." }, "child_count": 8, "reference_id": "MONDO:0006167" }, { "id": 7844, "label": "mixed lobular and ductal breast carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6729, 7464 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000382", "ICD9:174.8", "MEDGEN:1779609", "NCIT:C5160", "ONCOTREE:MDLC", "SCTID:444604002", "UMLS:C5441546" ], "synonyms": [ "ductal and lobular carcinoma", "mixed ductal and lobular breast carcinoma", "mixed ductal and lobular carcinoma of breast", "mixed ductal and lobular carcinoma of the breast", "mixed lobular and ductal breast carcinoma", "mixed lobular and ductal carcinoma", "mixed lobular and ductal carcinoma of breast", "mixed lobular and ductal carcinoma of the breast", "breast mixed ductal and lobular carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A breast carcinoma characterized by the presence of a lobular and a ductal component. The ductal component comprises less than 50 percent of the tumor." }, "child_count": 2, "reference_id": "MONDO:0006306" }, { "id": 11906, "label": "gonadoblastoma", "isLeaf": false, "isRoot": false, "parents": [ 4279, 4375, 4558, 7213, 7464, 7639 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3301", "ICDO:9073/1", "MEDGEN:104912", "MESH:D018238", "NCIT:C3754", "ONCOTREE:OGBL", "UMLS:C0206661" ], "synonyms": [ "gonad blastoma", "gonadoblastoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A mixed germ cell/sex cord-stromal tumor characterized by the presence of large germ cells which resemble seminoma cells and small cells which resemble Sertoli or granulosa cells. It occurs in the testis and the ovary and is identified in children and adults. It is often associated with gonadal dysgenesis and abnormal karyotype." }, "child_count": 12, "reference_id": "MONDO:0010768" }, { "id": 17165, "label": "anaplastic oligoastrocytoma", "isLeaf": true, "isRoot": false, "parents": [ 7464, 17164, 20048, 20696 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0002500", "GARD:0010637", "MEDGEN:96556", "NCIT:C6959", "ONCOTREE:AOAST", "Orphanet:251663", "UMLS:C0431108" ], "synonyms": [ "WHO grade III mixed glioma", "aMOA", "anaplastic mixed glioma", "anaplastic oligoastrocytoma", "AOAST" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity." }, "child_count": 0, "reference_id": "MONDO:0016703" }, { "id": 21581, "label": "malignant mixed epithelial stromal tumor of the kidney", "isLeaf": true, "isRoot": false, "parents": [ 4465, 4482, 7464 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:233156", "NCIT:C37265", "UMLS:C1334602" ], "synonyms": [ "malignant MEST", "malignant mixed epithelial stromal tumor of the kidney", "mixed epithelial stromal tumor of the kidney, malignant", "mixed epithelial stromal tumour of the kidney, malignant" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A mixed epithelial stromal tumor of the kidney with malignant stromal features." }, "child_count": 0, "reference_id": "MONDO:0024711" }, { "id": 22955, "label": "malignant phyllodes tumor", "isLeaf": false, "isRoot": false, "parents": [ 6806, 7464 ], "type_id": 0, "properties": { "xrefs": [ "ICDO:9020/3", "MEDGEN:109372", "NCIT:C4275", "UMLS:C0600066" ], "synonyms": [ "malignant cystosarcoma phyllodes", "malignant phyllodes neoplasm", "malignant phyllodes tumor", "phyllodes tumor, malignant" ], "definition": "A phyllodes tumor with sarcomatous stroma. The sarcomatous component is usually of the fibrosarcomatous type. Liposarcomatous, chondrosarcomatous, osteosarcomatous, or rhabdomyosarcomatous differentiation may also occur in the stroma. It may recur and metastasize following surgical resection. The lung and skeleton are the anatomic sites most frequently involved by metastases." }, "child_count": 4, "reference_id": "MONDO:0037003" }, { "id": 22976, "label": "malignant vaginal mixed epithelial and mesenchymal neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 3623, 7464 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:307683", "NCIT:C40276", "UMLS:C1512974" ], "synonyms": [ "malignant vaginal mixed epithelial and mesenchymal neoplasm", "malignant vaginal mixed epithelial and mesenchymal tumor", "malignant vaginal mixed epithelial and mesenchymal tumour" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A malignant neoplasm that arises from the vagina and is characterized by the presence of an epithelial and a mesenchymal component. This category includes adenosarcoma, carcinosarcoma, and malignant mixed tumor resembling synovial sarcoma." }, "child_count": 2, "reference_id": "MONDO:0037746" }, { "id": 29304, "label": "adenoacanthoma", "isLeaf": true, "isRoot": false, "parents": [ 6712, 7464 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:90777", "UMLS:C0334393" ], "synonyms": [ "adenoacanthoma", "adenocarcinoma with squamous metaplasia" ], "definition": "An invasive adenocarcinoma characterized by the presence of focal or extensive transformation of malignant glandular cells to squamous epithelial cells." }, "child_count": 0, "reference_id": "MONDO:1060121" } ], "roots": [ { "id": 6733, "label": "cancer" }, { "id": 20288, "label": "mixed neoplasm" } ] }