{
  "id": 7497,
  "label": "pancreatic endocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005893",
  "properties": {
    "xrefs": [
      "DOID:1798",
      "EFO:0007416",
      "GARD:0022056",
      "ICD10CM:C25.4",
      "ICD9:157.4",
      "ICDO:8150/3",
      "MEDGEN:233070",
      "MESH:D018273",
      "NCIT:C3770",
      "Orphanet:506098",
      "SCTID:254612002",
      "UMLS:C1328479"
    ],
    "synonyms": [
      "Pancreatic Neuroendocrine cancer",
      "carcinoma of endocrine pancreas",
      "carcinoma, islet cell, malignant",
      "endocrine pancreas carcinoma",
      "high grade pancreatic neuroendocrine carcinoma",
      "high-grade pancreatic neuroendocrine carcinoma",
      "islet cell cancer",
      "islet cell carcinoma",
      "islet cell carcinoma (morphologic abnormality)",
      "malignant islet cell tumor",
      "malignant islet cell tumour",
      "malignant neoplasm of islets of Langerhans",
      "malignant pancreatic endocrine tumor",
      "malignant pancreatic endocrine tumour",
      "pancreatic NEC",
      "pancreatic NEC G3",
      "pancreatic endocrine cancer",
      "pancreatic endocrine carcinoma",
      "pancreatic neuroendocrine carcinoma",
      "poorly differentiated pancreatic endocrine carcinoma",
      "poorly-differentiated NEN of pancreas",
      "poorly-differentiated neuroendocrine neoplasm of pancreas",
      "poorly-differentiated pancreatic NEN",
      "poorly-differentiated pancreatic neuroendocrine neoplasm",
      "neuroendocrine carcinoma of pancreas"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 7431,
      "label": "pancreatic neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4104,
        20285,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1799",
          "EFO:0007331",
          "GARD:0022052",
          "ICDO:8150/1",
          "MEDGEN:1848937",
          "NCIT:C27031",
          "Orphanet:506052",
          "SCTID:254611009",
          "UMLS:C5848399",
          "icd11.foundation:1421495979"
        ],
        "synonyms": [
          "PNEN",
          "endocrine pancreas neoplasm",
          "endocrine pancreas neoplasm (disease)",
          "endocrine pancreas tumor",
          "endocrine pancreas tumour",
          "neoplasm of endocrine pancreas",
          "pancreatic NEN",
          "pancreatic endocrine neoplasm",
          "pancreatic neuroendocrine neoplasm",
          "tumor of endocrine pancreas",
          "tumour of endocrine pancreas",
          "Islet cell tumors",
          "Islet cell tumours",
          "endocrine pancreas cancer",
          "islet cell neoplasm",
          "islet cell tumor",
          "islet cell tumour",
          "malignant pancreatic endocrine tumor",
          "malignant pancreatic endocrine tumour",
          "Islet of Langerhans tumor",
          "Islet of Langerhans tumour",
          "neuroendocrine neoplasm of pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the pancreas. It includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine carcinomas (high grade)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005815"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050922",
          "EFO:1000218",
          "HP:0002672",
          "MEDGEN:57467",
          "NCIT:C96963",
          "UMLS:C0151544"
        ],
        "synonyms": [
          "carcinoma of digestive system",
          "carcinoma of the gastrointestinal system",
          "digestive system carcinoma",
          "gastrointestinal carcinoma",
          "gastrointestinal carcinoma (disease)",
          "gastrointestinal system carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0006181"
    },
    {
      "id": 11035,
      "label": "malignant pancreatic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        20285
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1793",
          "EFO:1000359",
          "GARD:0027792",
          "ICD10CM:C25",
          "ICD9:157.0",
          "ICD9:157.1",
          "ICD9:157.2",
          "ICD9:157.8",
          "MEDGEN:138068",
          "NCIT:C9005",
          "UMLS:C0346647",
          "icd11.foundation:542147910"
        ],
        "synonyms": [
          "pancreas neoplasm",
          "cancer of pancreas",
          "malignant neoplasm of pancreas",
          "malignant neoplasm of the pancreas",
          "malignant pancreas neoplasm",
          "malignant pancreatic neoplasm",
          "pancreas cancer",
          "pancreatic cancer",
          "pancreatic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the pancreas."
      },
      "child_count": 8,
      "reference_id": "MONDO:0009831"
    }
  ],
  "children": [
    {
      "id": 7873,
      "label": "pancreatic large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6787,
        6912,
        7497
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000442",
          "GARD:0024376",
          "MEDGEN:459465",
          "NCIT:C95582",
          "UMLS:C2987239"
        ],
        "synonyms": [
          "large cell neuroendocrine carcinoma of pancreas",
          "pancreas large cell neuroendocrine carcinoma",
          "pancreatic large cell NEC",
          "pancreatic large cell NEC G3",
          "pancreatic large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant large cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006347"
    },
    {
      "id": 7874,
      "label": "pancreatic small cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        7497
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000444",
          "GARD:0024377",
          "MEDGEN:459466",
          "NCIT:C95583",
          "UMLS:C2987240"
        ],
        "synonyms": [
          "endocrine pancreas small cell carcinoma",
          "pancreatic small cell NEC",
          "pancreatic small cell NEC G3",
          "pancreatic small cell neuroendocrine carcinoma",
          "small cell carcinoma of endocrine pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant small cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006348"
    }
  ],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 7431,
      "label": "pancreatic neuroendocrine neoplasm"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma"
    },
    {
      "id": 11035,
      "label": "malignant pancreatic neoplasm"
    }
  ]
}