{
  "id": 7531,
  "label": "pulmonary blastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005933",
  "properties": {
    "xrefs": [
      "DOID:4765",
      "EFO:0007458",
      "GARD:0018864",
      "ICD9:162.9",
      "ICDO:8972/3",
      "MEDGEN:61645",
      "MESH:D018202",
      "NCIT:C3732",
      "Orphanet:64741",
      "SCTID:189815007",
      "UMLS:C0206629"
    ],
    "synonyms": [
      "Pneumoblastoma",
      "blastoma of lung",
      "blastoma of the lung",
      "lung blastoma",
      "pulmonary blastoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A malignant neoplasm of the lung composed of tubular structures and immature mesenchymal elements, which may differentiate towards skeletal and smooth muscle, cartilage or a combination of muscle and cartilage. This is a nodular tumor found in the periphery of the lung. It can occur at any age. The prognosis is related to the stage of the disease at the time of resection. Pulmonary blastoma is divided into two subtypes: epithelial predominant and biphasic."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7213,
      "label": "blastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7212
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070003",
          "DOID:4766",
          "EFO:0005785",
          "ICDO:8981/3",
          "MEDGEN:181704",
          "NCIT:C8997",
          "UMLS:C0936282"
        ],
        "synonyms": [
          "blastoma",
          "embryoma"
        ],
        "definition": "A malignant neoplasm composed of undifferentiated cells."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005565"
    },
    {
      "id": 7822,
      "label": "lung sarcomatoid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5040,
        7925
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080777",
          "EFO:1000336",
          "ICD9:162.9",
          "MEDGEN:353871",
          "NCIT:C45540",
          "ONCOTREE:SARCL",
          "SCTID:707460002",
          "UMLS:C1708781"
        ],
        "synonyms": [
          "lung sarcomatoid carcinoma",
          "sarcomatoid carcinoma of the lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006279"
    }
  ],
  "children": [
    {
      "id": 5104,
      "label": "classic pulmonary blastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7531
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4767",
          "GARD:0023376",
          "MEDGEN:231445",
          "NCIT:C36054",
          "UMLS:C1332556"
        ],
        "synonyms": [
          "biphasic pulmonary blastoma",
          "classic pulmonary blastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A pulmonary blastoma composed of a mixture of irregular tubular structures and mesenchymal elements."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003128"
    },
    {
      "id": 5105,
      "label": "epithelial predominant pulmonary blastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7531
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4768",
          "GARD:0023377",
          "MEDGEN:234222",
          "NCIT:C36053",
          "UMLS:C1333420"
        ],
        "synonyms": [
          "epithelial predominant pulmonary blastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A non-encapsulated, well defined pulmonary blastoma, composed of irregular tubular structures. It affects mostly middle-aged adults and it is rare in children. The prognosis is better compared to the biphasic pulmonary blastoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003129"
    },
    {
      "id": 12140,
      "label": "pleuropulmonary blastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7531,
        8005,
        23957
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4769",
          "EFO:0009052",
          "GARD:0008757",
          "ICD9:162.9",
          "ICDO:8973/3",
          "MEDGEN:266105",
          "MESH:C537516",
          "NANDO:2200080",
          "NCIT:C5669",
          "OMIM:601200",
          "ONCOTREE:PPB",
          "Orphanet:64742",
          "SCTID:707670009",
          "UMLS:C1266144"
        ],
        "synonyms": [
          "childhood pulmonary blastoma",
          "paediatric pulmonary blastoma",
          "pediatric pulmonary blastoma",
          "pleuropulmonary blastoma",
          "pleuropulmonary blastoma (morphologic abnormality)",
          "pulmonary blastoma of childhood",
          "PPB",
          "PPB familial tumor and dysplasia syndrome",
          "PPB familial tumour and dysplasia syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the lungs and/or the pleura. Pleuropulmonary blastoma is seen in children. Microscopically, the tumor may show features of chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated sarcoma. In approximately 25% of patients with pleuropulmonary blastoma, there are other lesions or neoplasms that may affect patients or their families, including lung or kidney cysts, and ovarian or testicular neoplasms. Heterozygous germline mutations in DICER1 gene have been identified in families harboring pleuropulmonary blastomas."
      },
      "child_count": 12,
      "reference_id": "MONDO:0011014"
    }
  ],
  "roots": [
    {
      "id": 7213,
      "label": "blastoma"
    },
    {
      "id": 7822,
      "label": "lung sarcomatoid carcinoma"
    }
  ]
}