{
  "id": 7568,
  "label": "syphilis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005976",
  "properties": {
    "xrefs": [
      "DOID:4166",
      "EFO:0007504",
      "GARD:0027732",
      "ICD9:097.9",
      "MEDGEN:21447",
      "MESH:D013587",
      "MedDRA:10062120",
      "NCIT:C35055",
      "SCTID:76272004",
      "UMLS:C0039128",
      "icd11.foundation:455894495"
    ],
    "synonyms": [
      "Treponema pallidum caused disease or disorder",
      "Treponema pallidum disease or disorder",
      "Treponema pallidum infectious disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A contagious bacterial infection caused by the spirochete Treponema pallidum. It is a sexually transmitted disorder, although it can also be transmitted from the mother to the fetus in utero. Typically, it is initially manifested with a single sore which heals without treatment. If the infection is left untreated, the initial stage is followed by skin rash and mucous membrane lesions. A late stage follows, which is characterized by damage of the internal organs, including the nervous system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 2837,
      "label": "primary bacterial infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050338"
        ]
      },
      "child_count": 37,
      "reference_id": "MONDO:0000314"
    },
    {
      "id": 8423,
      "label": "Treponema infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7014,
        20723,
        20765
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001217",
          "GARD:0007798",
          "MESH:D014211",
          "NCIT:C85197"
        ],
        "synonyms": [
          "Treponema caused disease or disorder",
          "Treponema disease or disorder",
          "Bejels",
          "bejel",
          "Treponemal infection",
          "infection, Treponemal",
          "infections, Treponemal"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An disease caused by infection with Treponema."
      },
      "child_count": 12,
      "reference_id": "MONDO:0007000"
    }
  ],
  "children": [
    {
      "id": 3902,
      "label": "bejel",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13431",
          "GARD:0005905",
          "ICD10CM:A65",
          "MEDGEN:2569",
          "NORD:847",
          "UMLS:C0004945"
        ],
        "synonyms": [
          "Njovera",
          "Treponema pallidum subsp. endemicum caused disease or disorder",
          "Treponema pallidum subsp. endemicum disease or disorder",
          "Treponema pallidum subsp. endemicum infectious disease",
          "nonvenereal endemic syphilis",
          "Dichuchwa",
          "Frenga",
          "endemic syphilis",
          "nonvenereal syphilis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A chronic skin and tissue disease caused by infection by the endemicum subspecies of the spirochete Treponema pallidum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001714"
    },
    {
      "id": 4905,
      "label": "primary syphilis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4156",
          "GARD:0027623",
          "ICD9:091",
          "MEDGEN:419772",
          "MESH:C536772",
          "NCIT:C128412",
          "SCTID:186846005",
          "UMLS:C2931317"
        ],
        "synonyms": [
          "early syphilis, symptomatic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "The subclinical or symptomatic stage of syphilis, occurring at an average of three weeks after contact with an infected individual. It manifests with one or more painless, indurated ulcers (chancres) of the skin or mucous membranes at the site of inoculation. These lesions heal spontaneously within a few weeks."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002896"
    },
    {
      "id": 4906,
      "label": "secondary syphilis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4157",
          "GARD:0023292",
          "ICD9:091.89",
          "ICD9:091.9",
          "MEDGEN:101776",
          "MESH:C536773",
          "NCIT:C128413",
          "SCTID:240557004",
          "UMLS:C0149985"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "The secondary stage of syphilis typically that is characterized by generalized rash (including palms and soles), mucocutaneous lesions, and lymphadenopathy. It usually begins one to two months after the primary stage."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002897"
    },
    {
      "id": 6299,
      "label": "tertiary syphilis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8200",
          "GARD:0027683",
          "ICD10CM:A52",
          "ICD9:095.8",
          "ICD9:095.9",
          "ICD9:097.0",
          "MEDGEN:56297",
          "MESH:C536774",
          "NCIT:C128414",
          "SCTID:72083004",
          "UMLS:C0153188"
        ],
        "synonyms": [
          "late syphilis",
          "late tertiary syphilis",
          "tertiary syphilis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A stage of syphilis that occurs fifteen to thirty years after the initial infection; it can include gumma formation and cardiovascular or central nervous system involvement (neurosyphilis)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004497"
    },
    {
      "id": 7342,
      "label": "congenital syphilis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7568,
        17014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9856",
          "EFO:0007219",
          "GARD:0022036",
          "ICD10CM:A50",
          "ICD10WHO:A50",
          "ICD9:090",
          "ICD9:090.9",
          "MEDGEN:52622",
          "MESH:D013590",
          "NCIT:C84649",
          "NORD:1753",
          "Orphanet:499009",
          "SCTID:35742006",
          "UMLS:C0039131",
          "icd11.foundation:587996426"
        ],
        "synonyms": [
          "MTCT of syphilis",
          "congenital syphilis",
          "mother-to-child transmission of syphilis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005714"
    },
    {
      "id": 7436,
      "label": "latent syphilis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9531",
          "EFO:0007340",
          "GARD:0027729",
          "ICD9:097.1",
          "MEDGEN:21056",
          "MESH:D013592",
          "NCIT:C35056",
          "SCTID:444150000",
          "UMLS:C0039133"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A stage of syphilis characterized by the serologic evidence of infection by Treponema pallidum without evidence of accompanying signs or symptoms related to the disease."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005822"
    },
    {
      "id": 7608,
      "label": "yaws",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10371",
          "GARD:0007913",
          "ICD10CM:A66",
          "ICD10WHO:A66",
          "ICD9:102",
          "ICD9:102.7",
          "ICD9:102.9",
          "MEDGEN:12186",
          "MESH:D015001",
          "NCIT:C41353",
          "NORD:1872",
          "SCTID:70647001",
          "UMLS:C0043388",
          "icd11.foundation:840525023"
        ],
        "synonyms": [
          "Bouba",
          "Treponema pallidum subsp. pertenue caused disease or disorder",
          "Treponema pallidum subsp. pertenue disease or disorder",
          "Treponema pallidum subsp. pertenue infectious disease",
          "frambesia",
          "frambesia tropica",
          "Treponema pertenue infection",
          "endemic treponematoses"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006019"
    },
    {
      "id": 8179,
      "label": "cutaneous syphilis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7568,
        21329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000887",
          "GARD:0027763",
          "MEDGEN:52623",
          "MESH:D013591",
          "UMLS:C0039132"
        ],
        "synonyms": [
          "Treponema pallidum caused skin disease caused by bacterial infection",
          "Treponema pallidum skin disease caused by bacterial infection"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Cutaneous lesions arising from infection with Treponema pallidum. In the primary stage, 18-21 days following infection, one or more chancres appear. If untreated, the subsequent stages of the disease appear as syphilids. These eruptions are superficial, nondestructive, exanthematic, transient, macular roseolas that may later be maculopapular or papular polymorphous or scaly, pustular, pigmented eruptions.(Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p409)"
      },
      "child_count": 2,
      "reference_id": "MONDO:0006718"
    },
    {
      "id": 8415,
      "label": "syphilitic aortitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001206",
          "GARD:0027769",
          "ICD10CM:A52.02",
          "ICD9:093.1",
          "MEDGEN:364",
          "MedDRA:10042900",
          "SCTID:20735004",
          "UMLS:C0003511",
          "icd11.foundation:921262131"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Cardiovascular manifestations of syphilis, an infection of treponema pallidum. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the aorta and the aortic valve. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic aneurysm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006992"
    },
    {
      "id": 8445,
      "label": "chancre",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001247",
          "GARD:0027771",
          "MEDGEN:671172",
          "MESH:D002601",
          "UMLS:C0600049"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "The primary sore of syphilis, a painless indurated, eroded papule, occurring at the site of entry of the infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007025"
    }
  ],
  "roots": [
    {
      "id": 2837,
      "label": "primary bacterial infectious disease"
    },
    {
      "id": 8423,
      "label": "Treponema infectious disease"
    }
  ]
}