{
  "id": 7594,
  "label": "uterine corpus cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006003",
  "properties": {
    "xrefs": [
      "DOID:9460",
      "EFO:0007532",
      "ICD9:182",
      "NCIT:C61574",
      "SCTID:371972005"
    ],
    "synonyms": [
      "body of uterus cancer",
      "cancer of body of uterus",
      "cancer of the corpus uteri",
      "corpus uteri cancer",
      "malignant body of uterus neoplasm",
      "malignant neoplasm of body of uterus",
      "uterine (including endometrial) cancer",
      "uterine corpus cancer",
      "endometrial cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A malignant neoplasm involving the body of uterus."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 4754,
      "label": "uterine cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3637,
        20520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:363",
          "ICD9:179",
          "MEDGEN:57791",
          "MESH:D014594",
          "NCIT:C3552",
          "SCTID:371973000",
          "UMLS:C0153567",
          "icd11.foundation:1551596364"
        ],
        "synonyms": [
          "neoplasm of uterus",
          "tumor of uterus",
          "tumour of uterus",
          "uterine tumor",
          "uterine tumour",
          "uterus neoplasm",
          "cancer of the uterus",
          "cancer of uterus",
          "malignant neoplasm of the uterus",
          "malignant neoplasm of uterus",
          "malignant tumor of the uterus",
          "malignant tumor of uterus",
          "malignant tumour of the uterus",
          "malignant tumour of uterus",
          "malignant uterine neoplasm",
          "malignant uterine tumor",
          "malignant uterine tumour",
          "malignant uterus neoplasm",
          "uterine cancer",
          "uterus cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Primary or metastatic malignant neoplasm involving the uterine corpus and/or the cervix."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002715"
    },
    {
      "id": 20461,
      "label": "corpus uteri neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:226810",
          "NCIT:C6300",
          "SCTID:126909004",
          "UMLS:C1263777"
        ],
        "synonyms": [
          "body of uterus neoplasm",
          "body of uterus neoplasm (disease)",
          "body of uterus tumor",
          "body of uterus tumour",
          "corpus uteri tumor",
          "corpus uteri tumour",
          "neoplasm of body of uterus",
          "neoplasm of corpus uteri",
          "neoplasm of the body of uterus",
          "neoplasm of the corpus uteri",
          "neoplasm of the uterine body",
          "neoplasm of the uterine corpus",
          "neoplasm of uterine body",
          "neoplasm of uterine corpus",
          "tumor of body of uterus",
          "tumor of corpus uteri",
          "tumor of the corpus uteri",
          "tumor of the uterine body",
          "tumor of the uterine corpus",
          "tumor of uterine body",
          "tumor of uterine corpus",
          "tumour of body of uterus",
          "tumour of corpus uteri",
          "tumour of the corpus uteri",
          "tumour of the uterine body",
          "tumour of the uterine corpus",
          "tumour of uterine body",
          "tumour of uterine corpus",
          "uterine body neoplasm",
          "uterine body tumor",
          "uterine body tumour",
          "uterine corpus neoplasm",
          "uterine corpus tumor",
          "uterine corpus tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the body of uterus."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021254"
    }
  ],
  "children": [
    {
      "id": 2992,
      "label": "uterine corpus endometrial carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4530,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050939"
        ],
        "synonyms": [
          "body of uterus endometrial carcinoma (disease)",
          "endometrial carcinoma (disease) of body of uterus"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A endometrial carcinoma (disease) that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000553"
    },
    {
      "id": 4892,
      "label": "uterine body mixed cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7464,
        7594,
        16821
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4114",
          "GARD:0023285",
          "MEDGEN:233163",
          "NCIT:C6311",
          "UMLS:C1334628"
        ],
        "synonyms": [
          "malignant body of uterus mixed neoplasm",
          "malignant body of uterus mixed tumor",
          "malignant body of uterus mixed tumour",
          "malignant corpus uteri mixed neoplasm",
          "malignant corpus uteri mixed tumor",
          "malignant corpus uteri mixed tumour",
          "malignant mixed neoplasm of body of uterus",
          "malignant mixed neoplasm of corpus uteri",
          "malignant mixed neoplasm of the body of uterus",
          "malignant mixed neoplasm of the corpus uteri",
          "malignant mixed neoplasm of the uterine body",
          "malignant mixed neoplasm of the uterine corpus",
          "malignant mixed neoplasm of uterine body",
          "malignant mixed neoplasm of uterine corpus",
          "malignant mixed tumor of body of uterus",
          "malignant mixed tumor of corpus uteri",
          "malignant mixed tumor of the body of uterus",
          "malignant mixed tumor of the corpus uteri",
          "malignant mixed tumor of the uterine body",
          "malignant mixed tumor of the uterine corpus",
          "malignant mixed tumor of uterine body",
          "malignant mixed tumor of uterine corpus",
          "malignant mixed tumour of body of uterus",
          "malignant mixed tumour of corpus uteri",
          "malignant mixed tumour of the body of uterus",
          "malignant mixed tumour of the corpus uteri",
          "malignant mixed tumour of the uterine body",
          "malignant mixed tumour of the uterine corpus",
          "malignant mixed tumour of uterine body",
          "malignant mixed tumour of uterine corpus",
          "malignant uterine body mixed neoplasm",
          "malignant uterine body mixed tumor",
          "malignant uterine body mixed tumour",
          "malignant uterine corpus mixed epithelial and mesenchymal neoplasm",
          "malignant uterine corpus mixed tumor",
          "malignant uterine corpus mixed tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary malignant neoplasm of the uterine corpus characterized by the presence of an epithelial and a mesenchymal component. This category includes carcinosarcoma, carcinofibroma, and adenosarcoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002879"
    },
    {
      "id": 6926,
      "label": "uterine corpus sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5165",
          "EFO:0002914",
          "GARD:0020476",
          "MEDGEN:137837",
          "MedDRA:10039497",
          "NCIT:C6339",
          "ONCOTREE:USARC",
          "Orphanet:213620",
          "SCTID:254877001",
          "UMLS:C0338113"
        ],
        "synonyms": [
          "body of uterus sarcoma",
          "corpus uteri sarcoma",
          "sarcoma of body of uterus",
          "sarcoma of corpus uteri",
          "sarcoma of the body of uterus",
          "sarcoma of the corpus uteri",
          "sarcoma of the uterine body",
          "sarcoma of the uterine corpus",
          "sarcoma of uterine body",
          "sarcoma of uterine corpus",
          "sarcoma of uterus",
          "uterine body sarcoma",
          "uterus sarcoma",
          "sarcoma of the uterus",
          "uterine sarcoma",
          "uterine sarcoma/mesenchymal"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant mesenchymal neoplasm arising from the wall of the uterine corpus (uterine body). The most representative examples are leiomyosarcoma and endometrial stromal sarcoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005210"
    },
    {
      "id": 7751,
      "label": "endometrial serous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        6974,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5750",
          "EFO:1000238",
          "MEDGEN:1659908",
          "NCIT:C27838",
          "ONCOTREE:USC",
          "UMLS:C0854924",
          "icd11.foundation:225222541"
        ],
        "synonyms": [
          "uterine serous adenocarcinoma",
          "uterine serous carcinoma",
          "body of uterus serous adenocarcinoma",
          "endometrial serous adenocarcinoma",
          "serous endometrial adenocarcinoma",
          "uterine corpus serous adenocarcinoma",
          "uterine papillary serous carcinoma",
          "uterine serous papillary adenocarcinoma",
          "uterine serous carcinoma/uterine papillary serous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A high grade, aggressive adenocarcinoma arising from the endometrium. It is characterized by the presence of complex papillary patterns with cellular budding. Atypical mitoses, necrosis, and psammoma bodies may be present. It is classified as type II endometrial carcinoma and it is not associated with endometrial hyperplasia. It tends to invade deeply into the myometrium and spreads into the lymphatic vessels. Patients frequently present with spread of the tumor beyond the uterus at the time of diagnosis. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006196"
    },
    {
      "id": 16829,
      "label": "squamous cell carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6823,
        6929,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020479",
          "MEDGEN:1633992",
          "Orphanet:213716",
          "UMLS:C4707099"
        ],
        "synonyms": [
          "body of uterus squamous cell carcinoma",
          "endometrial squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016266"
    },
    {
      "id": 16830,
      "label": "undifferentiated carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7257,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020480",
          "ICD10CM:C54.9",
          "MEDGEN:1638762",
          "Orphanet:213721",
          "UMLS:C4707822"
        ],
        "synonyms": [
          "body of uterus undifferentiated carcinoma",
          "endometrial undifferentiated carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Undifferentiated carcinoma of the corpus uteri is a rare cancer of corpus uteri presenting as a large, polypoid, intraluminal mass with necrosis, composed of small to intermediate-size, relatively uniform, dyshesive cells displaying no differentiation. It usually presents with dysfunctional bleeding or vaginal discharge and, less often, abdominal pain. Association with Lynch syndrome was reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016267"
    },
    {
      "id": 16831,
      "label": "papillary carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7594,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020481",
          "MEDGEN:1805139",
          "Orphanet:213726",
          "UMLS:C5679804"
        ],
        "synonyms": [
          "body of uterus papillary carcinoma",
          "endometrial capillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A papillary carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016268"
    },
    {
      "id": 16832,
      "label": "high-grade neuroendocrine carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7594,
        20310,
        20702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020482",
          "MEDGEN:1664315",
          "Orphanet:213731",
          "UMLS:C4751234"
        ],
        "synonyms": [
          "high-grade neuroendocrine carcinoma of the uterine corpus",
          "poorly differentiated neuroendocrine carcinoma of the corpus uteri",
          "poorly differentiated neuroendocrine carcinoma of the endometrium"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "High-grade neuroendocrine carcinoma of the corpus uteri is an extremely rare, aggressive, primary uterine neoplasm, originating from neuroendocrine cells scattered within the endometrium, characterized, macroscopically, by a bulky, frequently polypoid, mass with abundant necrosis located in the uterus and, histologically, by rosette-like and cord-like structures consisting of small, rounded cells with oval nuclei and scarce cytoplasm. Patients often present with dysfunctional uterine bleeding, pelvic or abdominal mass and, especially in later stages of the disease, abdominal pain. Symptomatic metastatic spread or symptoms related to a paraneoplastic syndrome, such as retinopathy, or Cushing syndrome due to ectopic ACTH production, may be associated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016269"
    },
    {
      "id": 16833,
      "label": "low-grade neuroendocrine tumor of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7594,
        20310,
        20702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020483",
          "MEDGEN:1672976",
          "NCIT:C126773",
          "Orphanet:213736",
          "UMLS:C5190779"
        ],
        "synonyms": [
          "low-grade neuroendocrine tumor of the uterine corpus",
          "low-grade neuroendocrine tumour of the uterine corpus",
          "well-differentiated neuroendocrine neoplasm of the endometrium",
          "well-differentiated neuroendocrine tumor of the corpus uteri",
          "well-differentiated neuroendocrine tumor of the endometrium",
          "well-differentiated neuroendocrine tumour of the corpus uteri",
          "well-differentiated neuroendocrine tumour of the endometrium"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Low-grade neuroendocrine tumor of the corpus uteri is an extremely rare uterine cancer typically characterized by a well demarcated, solid, frequently pedunculated tumor originating from neuroendocrine cells scattered within the endometrium, often associated with ectopic hormone production. Patients usually present with vaginal bleeding or discharge and a pelvic mass with a polypoid tumor sometimes protruding through the cervical canal. Symptoms related to ectopic hormone production (flushing, sweating, diarrhea, bronchospasm) may also develop."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016270"
    },
    {
      "id": 16834,
      "label": "adenoid cystic carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6929,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:213741",
          "icd11.foundation:350868040"
        ],
        "synonyms": [
          "body of uterus adenoid cystic carcinoma",
          "endometrial adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A adenoid cystic carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016271"
    },
    {
      "id": 16835,
      "label": "transitional cell carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7594,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020484",
          "MEDGEN:1676303",
          "Orphanet:213746",
          "UMLS:C5191668"
        ],
        "synonyms": [
          "body of uterus transitional cell carcinoma",
          "endometrial transitional cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A transitional cell carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016272"
    },
    {
      "id": 16836,
      "label": "malignant germ cell tumor of corpus uteri",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7594,
        7832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020485",
          "MEDGEN:1655229",
          "Orphanet:213751",
          "UMLS:C4750753"
        ],
        "synonyms": [
          "body of uterus malignant germ cell tumor",
          "body of uterus malignant germ cell tumour",
          "germ cell cancer of corpus uteri",
          "germ cell cancer of the corpus uteri",
          "malignant germ cell tumor of the corpus uteri",
          "malignant germ cell tumour of the corpus uteri"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that involves the body of uterus."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016273"
    }
  ],
  "roots": [
    {
      "id": 4754,
      "label": "uterine cancer"
    },
    {
      "id": 20461,
      "label": "corpus uteri neoplasm"
    }
  ]
}