{
  "id": 7597,
  "label": "verrucous carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006006",
  "properties": {
    "xrefs": [
      "DOID:3737",
      "EFO:0007535",
      "ICD9:199.1",
      "ICDO:8051/3",
      "MEDGEN:60213",
      "MESH:D018289",
      "NCIT:C3781",
      "SCTID:403904009",
      "UMLS:C0206706"
    ],
    "synonyms": [
      "verrucous carcinoma",
      "verrucous carcinoma NOS (morphologic abnormality)",
      "verrucous epidermoid carcinoma",
      "verrucous epidermoid cell carcinoma",
      "verrucous squamous carcinoma",
      "verrucous squamous cell carcinoma",
      "warty carcinoma"
    ],
    "definition": "A well differentiated squamous cell carcinoma characterized by a papillary growth pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, esophagus, anus, vagina, vulva, and the plantar region of the foot."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 4983,
      "label": "papillary squamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4385",
          "ICDO:8052/3",
          "MEDGEN:83115",
          "NCIT:C4102",
          "UMLS:C0334244"
        ],
        "synonyms": [
          "papillary epidermoid carcinoma",
          "papillary epidermoid cell carcinoma",
          "papillary squamous carcinoma",
          "papillary squamous cell carcinoma"
        ],
        "definition": "A well differentiated squamous cell carcinoma characterized by a papillary, exophytic growth pattern and hyperkeratosis. The most commonly affected anatomic sites are the larynx, penis, cervix, vagina, and vulva."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002979"
    }
  ],
  "children": [
    {
      "id": 4792,
      "label": "vulva verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7597,
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3740",
          "GARD:0023236",
          "MEDGEN:234482",
          "NCIT:C6383",
          "UMLS:C1336983"
        ],
        "synonyms": [
          "mammalian vulva verrucous carcinoma",
          "verrucous carcinoma of the vulva",
          "verrucous carcinoma of vulva",
          "vulvar verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A highly differentiated squamous cell carcinoma that arises from the vulva. It is characterized by the presence of a warty and hyperkeratinized surface, malignant cells with abundant eosinophilic cytoplasm, minimal cytologic atypia, and absence or rarity of mitotic figures. The tumor infiltrates the underlying stroma with a pushing border."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002758"
    },
    {
      "id": 4793,
      "label": "bladder verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4794,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3741",
          "MEDGEN:267376",
          "NCIT:C39832",
          "UMLS:C1511208"
        ],
        "synonyms": [
          "bladder verrucous carcinoma",
          "bladder verrucous squamous cell carcinoma",
          "urinary bladder verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A verrucous carcinoma that involves the urinary bladder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002759"
    },
    {
      "id": 4795,
      "label": "cervical verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7597,
        7706,
        16844
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3743",
          "GARD:0023237",
          "MEDGEN:275713",
          "NCIT:C40190",
          "UMLS:C1516435"
        ],
        "synonyms": [
          "cervical verrucous carcinoma",
          "uterine cervix verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A highly differentiated variant of cervical squamous cell carcinoma characterized by the presence of a warty surface and stromal invasion with pushing borders. The malignant cells have abundant cytoplasm and minimal nuclear atypia. Koilocytosis is not present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002761"
    },
    {
      "id": 4796,
      "label": "esophagus verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7225,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3747",
          "GARD:0023238",
          "MEDGEN:272594",
          "NCIT:C27420",
          "UMLS:C1333470"
        ],
        "synonyms": [
          "esophageal verrucous cancer",
          "esophageal verrucous carcinoma",
          "esophagus verrucous carcinoma",
          "verrucous carcinoma of esophagus",
          "verrucous carcinoma of the esophagus",
          "verrucous carcinoma of the oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare variant of esophageal squamous cell carcinoma. It is an exophytic, cauliflower-like or papillary mass that can arise in any part of the esophagus. This variant of squamous cell carcinoma grows slowly and invades locally, with a very low metastasizing potential. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0002762"
    },
    {
      "id": 4797,
      "label": "urethral verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4798,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3749",
          "GARD:0027617",
          "MEDGEN:274359",
          "NCIT:C39874",
          "UMLS:C1519827"
        ],
        "synonyms": [
          "urethra verrucous carcinoma",
          "urethral verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A verrucous carcinoma that involves the urethra."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002763"
    },
    {
      "id": 4799,
      "label": "plantar verrucous skin carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3751",
          "MEDGEN:578859",
          "NCIT:C6811",
          "UMLS:C0349657"
        ],
        "synonyms": [
          "plantar part of pes verrucous carcinoma",
          "plantar verrucous carcinoma of skin",
          "plantar verrucous carcinoma of the skin",
          "plantar verrucous skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A verrucous carcinoma that involves the plantar part of pes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002765"
    },
    {
      "id": 4800,
      "label": "larynx verrucous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7239,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3752",
          "GARD:0023239",
          "MEDGEN:76097",
          "NCIT:C8188",
          "SCTID:707427000",
          "UMLS:C0280328"
        ],
        "synonyms": [
          "laryngeal throat verrucous cancer",
          "laryngeal verrucous carcinoma",
          "larynx verrucous carcinoma",
          "verrucous carcinoma of larynx",
          "verrucous carcinoma of the larynx"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A well differentaited, non-metastasizing squamous cell carcinoma arising from the larynx. It is an exophytic, warty, and slow growing tumor affecting predominantly older men. It is associated with tobacco smoking. Symptoms include hoarseness, airway obstruction, weight loss, dysphagia, and throat pain. If left untreated, it may cause extensive local destruction."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002766"
    },
    {
      "id": 5581,
      "label": "penis verrucous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6241,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5908",
          "GARD:0023621",
          "MEDGEN:234477",
          "NCIT:C6982",
          "ONCOTREE:VPSCC",
          "UMLS:C1336955"
        ],
        "synonyms": [
          "penis verrucous carcinoma",
          "squamous carcinoma of penis, verrucous type",
          "squamous carcinoma of the penis, verrucous type",
          "verrucous carcinoma of penis",
          "verrucous carcinoma of the penis",
          "verrucous penile carcinoma",
          "verrucous penile squamous carcinoma",
          "verrucous squamous carcinoma of penis",
          "verrucous squamous carcinoma of the penis",
          "verrucous penile squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A slow growing, locally recurring, very well differentiated papillary squamous cell carcinoma that arises from the penis. It is characterized by the presence of acanthosis and hyperkeratosis. The neoplastic infiltrate extends into the underlying stroma with a pushing border. Koilocytotic atypia is not present."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003698"
    },
    {
      "id": 20654,
      "label": "verrucous carcinoma of oral cavity",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6701,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025335",
          "MEDGEN:124716",
          "NCIT:C8174",
          "SCTID:403889000",
          "UMLS:C0280306"
        ],
        "synonyms": [
          "mouth verrucous carcinoma",
          "oral cavity verrucous cancer",
          "oral cavity verrucous carcinoma",
          "verrucous carcinoma of mouth",
          "verrucous carcinoma of the mouth",
          "verrucous carcinoma of the oral cavity"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A verrucous carcinoma that involves the oral cavity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021538"
    },
    {
      "id": 21745,
      "label": "Buschke Lowenstein tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        7283,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009663",
          "MEDGEN:473018",
          "MESH:D062688",
          "NCIT:C6371",
          "SCTID:402910001",
          "UMLS:C0276264"
        ],
        "synonyms": [
          "Buschke Lowenstein tumor",
          "giant condyloma acuminatum involving the prepuce and glans penis",
          "giant condyloma of Buschke and Lowenstein",
          "Buschke-Lowenstein tumor",
          "Buschke-Lowenstein tumour",
          "GCBL",
          "Giant condyloma Acuminatum",
          "Giant condyloma Acuminatums",
          "Giant condyloma of Buschke and Lowenstein",
          "Lowenstein tumor, Buschke",
          "anogenital type verrucous carcinoma",
          "condyloma Acuminatum, Giant",
          "condyloma Acuminatums, Giant",
          "tumor, Buschke Lowenstein",
          "tumor, Buschke-Lowenstein"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A verrucous carcinoma of the skin or mucosa that occurs in the anogenital region."
      },
      "child_count": 3,
      "reference_id": "MONDO:0027026"
    }
  ],
  "roots": [
    {
      "id": 4983,
      "label": "papillary squamous carcinoma"
    }
  ]
}