{
  "id": 7600,
  "label": "viral encephalitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006009",
  "properties": {
    "xrefs": [
      "DOID:646",
      "EFO:0007538",
      "GARD:0019433",
      "MEDGEN:116719",
      "MedDRA:10058805",
      "NCIT:C35302",
      "Orphanet:98252",
      "SCTID:34476008",
      "UMLS:C0243010"
    ],
    "synonyms": [
      "Viruses caused encephalitis",
      "Viruses encephalitis",
      "viral encephalitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Encephalitis resulting from viral infection."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 19721,
      "label": "infectious encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19673,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025151",
          "ICD9:049.8",
          "ICD9:323.4",
          "MEDGEN:108917",
          "MESH:D000069544",
          "NCIT:C79550",
          "SCTID:312215006",
          "UMLS:C0596773"
        ],
        "synonyms": [
          "encephalitis infection"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi."
      },
      "child_count": 20,
      "reference_id": "MONDO:0020067"
    },
    {
      "id": 21351,
      "label": "viral infection of central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6834,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025391",
          "ICD10CM:A80-A89",
          "ICD10WHO:A80-A89",
          "MEDGEN:91141",
          "MESH:D020805",
          "SCTID:302810003",
          "UMLS:C0348165"
        ],
        "synonyms": [
          "viral infection of central nervous system",
          "central nervous system viral infection",
          "viral disease of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 14,
      "reference_id": "MONDO:0024318"
    },
    {
      "id": 24062,
      "label": "primary viral infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6834
      ],
      "type_id": 0,
      "properties": {
        "definition": "The initial viral infectious disase that causes illness."
      },
      "child_count": 32,
      "reference_id": "MONDO:0100329"
    }
  ],
  "children": [
    {
      "id": 2812,
      "label": "Powassan encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        7600,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050179",
          "GARD:0022741",
          "ICD9:063.8",
          "MEDGEN:18601",
          "SCTID:416707008",
          "UMLS:C0032858",
          "icd11.foundation:1674038791"
        ],
        "synonyms": [
          "Powassan virus caused disease or disorder",
          "Powassan virus disease or disorder",
          "Powassan virus infectious disease",
          "powassan encephalitis virus infection",
          "encephalitis, powassan"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease caused by infection with Powassan virus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000276"
    },
    {
      "id": 5274,
      "label": "acute necrotizing encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5222",
          "GARD:0013233",
          "ICD9:049.8",
          "MEDGEN:83264",
          "NCIT:C35383",
          "SCTID:111897007",
          "UMLS:C0338418"
        ],
        "synonyms": [
          "acute necrotizing encephalitis",
          "ANE",
          "acute necrotizing encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A fulminant and often fatal demyelinating disease of the brain which primarily affects young adults and children. Clinical features include the rapid onset of weakness, seizures, and coma. It may follow a viral illness or mycoplasma pneumoniae infections but in most instances there is no precipitating event. Pathologic examination reveals marked perivascular demyelination and necrosis of white matter with microhemorrhages. (Adams et al., Principles of Neurology, 6th ed, pp924-5)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003336"
    },
    {
      "id": 5275,
      "label": "acute hemorrhagic encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5224",
          "GARD:0023458",
          "MEDGEN:231027",
          "NCIT:C35796",
          "UMLS:C1332149"
        ],
        "synonyms": [
          "acute hemorrhagic encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Acute encephalitis that is characterized by bleeding."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003337"
    },
    {
      "id": 7337,
      "label": "Colorado tick fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7600,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4885",
          "GARD:0019042",
          "ICD10CM:A93.2",
          "ICD9:066.1",
          "MEDGEN:40398",
          "MESH:D003121",
          "MedDRA:10010022",
          "NORD:989",
          "Orphanet:83595",
          "SCTID:6452009",
          "UMLS:C0009400",
          "icd11.foundation:951357413"
        ],
        "synonyms": [
          "American mountain fever",
          "Colorado tick encephalitis",
          "Colorado tick fever virus caused disease or disorder",
          "Colorado tick fever virus disease or disorder",
          "Colorado tick fever virus infectious disease",
          "Colorado tick-borne disease",
          "Mountain fever",
          "Mountain tick fever"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A febrile illness characterized by chills, aches, vomiting, leukopenia, and sometimes encephalitis. It is caused by the colorado tick fever virus, a reovirus transmitted by the tick Dermacentor andersoni."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005708"
    },
    {
      "id": 7358,
      "label": "eastern equine encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10841",
          "EFO:0007242",
          "GARD:0010821",
          "ICD10CM:A83.2",
          "ICD9:062.2",
          "MEDGEN:102258",
          "MESH:D020242",
          "MedDRA:10014587",
          "Orphanet:83594",
          "UMLS:C0153065",
          "icd11.foundation:682536148"
        ],
        "synonyms": [
          "Eastern equine encephalomyelitis",
          "Neuroinvasive Eastern equine encephalitis virus infection"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Eastern equine encephalitis (EEE) is an acute arboviral infection caused by an alphavirus of the Togaviridae family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. Seizures, which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005736"
    },
    {
      "id": 11038,
      "label": "subacute sclerosing panencephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8970",
          "EFO:0007502",
          "GARD:0007708",
          "ICD10CM:A81.1",
          "ICD9:046.2",
          "MEDGEN:52527",
          "MESH:D013344",
          "NANDO:1200195",
          "NANDO:1200196",
          "NANDO:1200198",
          "NANDO:2100245",
          "NANDO:2200899",
          "NCIT:C85171",
          "NORD:1743",
          "OMIM:260470",
          "Orphanet:2806",
          "UMLS:C0038522",
          "icd11.foundation:1098683540"
        ],
        "synonyms": [
          "Immunosuppressive measles encephalitis",
          "SSPE",
          "Subacute inclusion body encephalitis",
          "Subacute sclerosing panencephalitis",
          "Subacute sclerosing panencephalitis (disorder) [ambiguous]",
          "Van Bogaert disease",
          "Van Bogaert encephalitis",
          "subacute sclerosing panencephalitis",
          "Dawson disease",
          "Dawson encephalitis",
          "Subacute sclerosing leukoencephalitis",
          "panencephalitis, SUBACUTE sclerosing"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A chronic progressive encephalitis that develops a few years after measles infection and presents with a demyelination of the cerebral cortex."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009835"
    },
    {
      "id": 13569,
      "label": "herpes simplex encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6399,
        7600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006649",
          "MEDGEN:75794",
          "MESH:D020803",
          "NANDO:2200772",
          "NCIT:C84762",
          "NORD:1087",
          "Orphanet:1930",
          "UMLS:C0276226",
          "icd11.foundation:320069644"
        ],
        "synonyms": [
          "Encephalitis, Herpes Simplex",
          "HSE",
          "HSV encephalitis",
          "HSVE",
          "Herpes simplex meningo-encephalitis",
          "Herpes simplex neuroinvasion",
          "Simplexvirus caused infectious encephalitis",
          "Simplexvirus infectious encephalitis",
          "herpetic encephalitis",
          "Herpes simplex virus encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Herpes simplex virus encephalitis (HSE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSV often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012521"
    },
    {
      "id": 17853,
      "label": "tick-borne encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7600,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050175",
          "EFO:1001309",
          "GARD:0005216",
          "ICD10CM:A84",
          "ICD9:063.2",
          "MEDGEN:4034",
          "MESH:D004675",
          "MedDRA:10043848",
          "NCIT:C34579",
          "Orphanet:297",
          "UMLS:C0014061",
          "icd11.foundation:835129952"
        ],
        "synonyms": [
          "TBE",
          "Tick-borne viral encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Tick-borne encephalitis is caused by an arbovirus of the Flaviviridae family (tick-borne encephalitis virus, TBEV), transmitted principally by the bite of the Ixodes ricinus tick. The symptomology is biphasic, with the initial phase being associated with a flu-like illness and the second phase (occurring in less than 10% of patients) with symptoms of meningitis or, more rarely, meningoencephalitis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017572"
    },
    {
      "id": 19215,
      "label": "encephalitis lethargica",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7600,
        19722,
        20335
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5225",
          "GARD:0006332",
          "ICD9:049.8",
          "MEDGEN:4028",
          "MedDRA:10052369",
          "NCIT:C26761",
          "NCIT:C34576",
          "Orphanet:83600",
          "SCTID:186499007",
          "UMLS:C0014040",
          "icd11.foundation:1777779617"
        ],
        "synonyms": [
          "Von Economo encephalitis",
          "encephalitis lethargica",
          "epidemic encephalitis",
          "lethargic encephalitis",
          "von Economo's disease",
          "Von Economo’s disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A form of encephalitis, the etiology of which is uncertain, that is characterized by lethargy and headache."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019384"
    },
    {
      "id": 20036,
      "label": "mosquito-borne viral encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7600,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025184",
          "ICD10CM:A83",
          "ICD10WHO:A83",
          "MEDGEN:152945",
          "NCIT:C34823",
          "UMLS:C0751098"
        ],
        "synonyms": [
          "mosquito-borne viral encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Viral encephalitis that is transmitted by mosquitos."
      },
      "child_count": 10,
      "reference_id": "MONDO:0020601"
    },
    {
      "id": 21746,
      "label": "HHV-6 encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7544,
        7600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009667",
          "MEDGEN:363034",
          "UMLS:C1955629"
        ],
        "synonyms": [
          "Human Herpesvirus 6 encephalitis",
          "Variant A or HHV-6A",
          "Variant B or HHV-6B"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "HHV-6 encephalitis refers to inflammation of the brain due to an infection with human herpesvirus 6. People who have undergone allogeneic hematopoietic cell transplantation are at an increased risk for developing HHV-6 encephalitis, particularly when umbilical cord blood stem cells are used. People with immune system disorders may also be at an increased risk for developing this infection. Signs and symptoms vary, but often include confusion, anterograde amnesia (difficulty learning new information following the onset of amnesia), short-term memory loss, and seizures.Diagnosis often involves lumbar puncture, virus testing, and MRI. EEG 's may also be recommendedwhen seizures are suspected. HHV-6 encephalitis is treated with an antiviral agent with activity against HHV-6. Long term outlook (chance of full recovery) can vary considerably depending individual patient factors."
      },
      "child_count": 0,
      "reference_id": "MONDO:0027029"
    },
    {
      "id": 25667,
      "label": "borna virus encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7467,
        7600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026822",
          "MEDGEN:1843023",
          "MESH:D001890",
          "Orphanet:637051",
          "UMLS:C5816783"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A human disease caused by infection with Borna disease virus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0957421"
    }
  ],
  "roots": [
    {
      "id": 19721,
      "label": "infectious encephalitis"
    },
    {
      "id": 21351,
      "label": "viral infection of central nervous system"
    },
    {
      "id": 24062,
      "label": "primary viral infectious disease"
    }
  ]
}