{
  "id": 7606,
  "label": "Waterhouse-Friderichsen syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006015",
  "properties": {
    "xrefs": [
      "DOID:9931",
      "EFO:0007544",
      "GARD:0009449",
      "ICD10CM:A39.1",
      "ICD9:036.3",
      "MEDGEN:234675",
      "MESH:D014884",
      "MedDRA:10047847",
      "NCIT:C85225",
      "Orphanet:100067",
      "SCTID:36102002",
      "UMLS:C1403891",
      "icd11.foundation:2072098125"
    ],
    "synonyms": [
      "WFS",
      "meningococcal hemorrhagic adrenalitis",
      "Waterhouse–Friderichsen syndrome",
      "fatal pneumococcal Waterhouse-Friderichsen syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A serious disorder characterized by massive adrenal gland hemorrhage secondary to a bacterial infection, most often Neisseria meningitidis infection. It is manifested with decreased blood pressure, shock, disseminated intravascular coagulation, and adrenocortical insufficiency."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 19542,
      "label": "acute adrenal insufficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16073,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019257",
          "ICD10CM:E27.2",
          "ICD9:255.41",
          "MEDGEN:56227",
          "NCIT:C112840",
          "Orphanet:95409",
          "SCTID:24867002",
          "UMLS:C0151467",
          "icd11.foundation:114442391"
        ],
        "synonyms": [
          "Addisonian crisis",
          "acute adrenal failure",
          "acute adrenocortical insufficiency",
          "adrenal crisis",
          "adrenocortical crisis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary adrenal insufficiency caused by a sudden defective production of adrenal steroids (cortisol and aldosterone). It represents an emergency, thus the rapid recognition and prompt therapy are critical for survival even before the diagnosis is made."
      },
      "child_count": 4,
      "reference_id": "MONDO:0019801"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 19542,
      "label": "acute adrenal insufficiency"
    }
  ]
}