{
  "id": 7622,
  "label": "granulosa cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006036",
  "properties": {
    "xrefs": [
      "DOID:2999",
      "EFO:1000032",
      "MEDGEN:6676",
      "MESH:D006106",
      "NCIT:C3070",
      "ONCOTREE:GRCT",
      "UMLS:C0018206"
    ],
    "synonyms": [
      "granulosa cell neoplasm",
      "granulosa cell neoplasm (disease)",
      "granulosa cell tumor",
      "granulosa cell tumor, adult type (morphologic abnormality)",
      "granulosa cell tumor, sarcomatoid",
      "neoplasm of granulosa cell",
      "tumor of granulosa cell",
      "tumour of granulosa cell",
      "GRCT",
      "granulosa cell tumor, undetermined"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A slow-growing, malignant tumor, characterize by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumor that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003769",
          "ICD9:239.7",
          "MEDGEN:4044",
          "NCIT:C3010",
          "SCTID:387922007",
          "UMLS:C0014132"
        ],
        "synonyms": [
          "endocrine gland neoplasm (disease)",
          "endocrine gland tumor",
          "endocrine gland tumour",
          "endocrine neoplasm",
          "endocrine system neoplasm",
          "endocrine system tumor",
          "endocrine system tumour",
          "endocrine tumor",
          "endocrine tumour",
          "neoplasm of endocrine gland",
          "tumor of endocrine gland",
          "tumour of endocrine gland",
          "malignant endocrine tumor",
          "malignant endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002082"
    },
    {
      "id": 7639,
      "label": "sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:192",
          "EFO:1000052",
          "ICDO:8590/1",
          "MEDGEN:104926",
          "NANDO:2200072",
          "NCIT:C3794",
          "UMLS:C0206724"
        ],
        "synonyms": [
          "Sex cord stromal tumor",
          "Sex cord-stromal neoplasm",
          "Sex cord-stromal tumor",
          "Sex cord-stromal tumor, no ICD-O subtype",
          "Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)",
          "Sex cord-stromal tumour",
          "neoplasm of sex cord",
          "sex cord neoplasm",
          "sex cord tumor",
          "sex cord tumour",
          "sex cord-stromal tumor",
          "specialised gonadal neoplasm",
          "specialised gonadal neoplasm (morphologic abnormality)",
          "specialised gonadal neoplasm NOS (morphologic abnormality)",
          "specialised gonadal tumour",
          "specialised gonadal tumour (qualifier value)",
          "specialized gonadal neoplasm (morphologic abnormality)",
          "specialized gonadal neoplasm NOS (morphologic abnormality)",
          "specialized gonadal tumor (qualifier value)",
          "tumor of sex cord",
          "tumour of sex cord",
          "malignant testicular sex cord-stromal tumor",
          "malignant testicular sex cord-stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm involving a sex cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006055"
    }
  ],
  "children": [
    {
      "id": 5327,
      "label": "testicular granulosa cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5102,
        7622
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5331",
          "GARD:0023498",
          "MEDGEN:237001",
          "NCIT:C6357",
          "UMLS:C1336709"
        ],
        "synonyms": [
          "granulosa cell tumor of testis",
          "testicular granulosa cell tumor",
          "testis granulosa cell tumor",
          "testis granulosa cell tumour",
          "granulosa cell neoplasm of testis",
          "granulosa cell neoplasm of the testis",
          "granulosa cell tumor of the testis",
          "granulosa cell tumour of the testis",
          "testicular granulosa cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare sex cord-stromal tumor that arises from the testis. It is characterized by the presence of granulosa-like cells and Call-Exner bodies. There are two variants described, the adult and the juvenile."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003395"
    },
    {
      "id": 21206,
      "label": "ovarian granulosa cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7622,
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027911",
          "MEDGEN:277970",
          "MESH:C537296",
          "NCIT:C6261",
          "SCTID:254863004",
          "UMLS:C1370419"
        ],
        "synonyms": [
          "granulosa cell neoplasm of ovary",
          "granulosa cell neoplasm of the ovary",
          "granulosa cell tumor of ovary",
          "granulosa cell tumor of the ovary",
          "granulosa cell tumour of ovary",
          "granulosa cell tumour of the ovary",
          "ovarian granulosa cell neoplasm",
          "ovarian granulosa cell tumor",
          "ovary granulosa cell tumor",
          "ovary granulosa cell tumour",
          "GCT of the ovary",
          "adult granulosa cell tumor of the ovary",
          "adult granulosa cell tumour of the ovary",
          "granulosa theca cell tumor",
          "granulosa theca cell tumor of the ovary",
          "granulosa theca cell tumour",
          "granulosa theca cell tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0023283"
    }
  ],
  "roots": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm"
    },
    {
      "id": 7639,
      "label": "sex cord-stromal tumor"
    }
  ]
}