{
  "id": 7627,
  "label": "lung carcinoid tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006041",
  "properties": {
    "xrefs": [
      "EFO:1000037",
      "GARD:0024273",
      "MEDGEN:79070",
      "NCIT:C4038",
      "ONCOTREE:LUCA",
      "SCTID:254627002",
      "UMLS:C0280089"
    ],
    "synonyms": [
      "carcinoid tumor (disease) of lung",
      "carcinoid tumor of lung",
      "carcinoid tumor of the lung",
      "carcinoid tumour (disease) of lung",
      "carcinoid tumour of lung",
      "carcinoid tumour of the lung",
      "lung carcinoid tumor",
      "lung carcinoid tumor (disease)",
      "lung carcinoid tumour (disease)",
      "pulmonary carcinoid tumor",
      "pulmonary carcinoid tumour",
      "lung carcinoid"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neuroendocrine neoplasm that arises from the lung. It is characterized by the presence of uniform polygonal cells with small or moderate amount of cytoplasm and inconspicuous nucleoli. The cells are usually arranged in organoid and trabecular patterns. It is classified as typical or atypical carcinoid tumor based on the number of mitotic figures and the absence or presence of necrosis. Atypical carcinoid tumors have a worse prognosis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7051,
      "label": "carcinoid tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004243",
          "GARD:0024176",
          "HP:0100570",
          "ICD9:209.60",
          "ICDO:8240/3",
          "ICDO:8241/3",
          "MEDGEN:2838",
          "MESH:D002276",
          "NANDO:2200396",
          "NCIT:C2915",
          "SCTID:443492008",
          "UMLS:C0007095"
        ],
        "synonyms": [
          "NET G1",
          "carcinoid",
          "carcinoid tumor",
          "carcinoid tumor (disease)",
          "carcinoid tumour (disease)",
          "neuroendocrine neoplasm G1",
          "neuroendocrine tumor G1",
          "neuroendocrine tumour G1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005369"
    },
    {
      "id": 7117,
      "label": "lung neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19314,
        20356
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5410",
          "EFO:0005220",
          "GARD:0024190",
          "ICD9:209.61",
          "MEDGEN:277303",
          "NCIT:C5670",
          "ONCOTREE:LNET",
          "SCTID:707594002",
          "UMLS:C1334452"
        ],
        "synonyms": [
          "lung NET",
          "lung neuroendocrine neoplasm",
          "lung neuroendocrine tumor",
          "lung neuroendocrine tumor, well differentiated, low or intermediate grade",
          "lung neuroendocrine tumour",
          "neuroendocrine neoplasm of lung",
          "neuroendocrine neoplasm of the lung",
          "pulmonary neuroendocrine neoplasm",
          "pulmonary neuroendocrine tumor",
          "pulmonary neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A low, intermediate, or high grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005454"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7051,
      "label": "carcinoid tumor"
    },
    {
      "id": 7117,
      "label": "lung neuroendocrine neoplasm"
    }
  ]
}