{
  "id": 7633,
  "label": "pancreatic adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006047",
  "properties": {
    "xrefs": [
      "DOID:4074",
      "EFO:1000044",
      "GARD:0027736",
      "MEDGEN:83800",
      "NCIT:C8294",
      "ONCOTREE:PAAD",
      "SCTID:700423003",
      "UMLS:C0281361",
      "icd11.foundation:1663659989"
    ],
    "synonyms": [
      "adenocarcinoma - pancreas",
      "adenocarcinoma of pancreas",
      "adenocarcinoma of the pancreas",
      "pancreas adenocarcinoma",
      "pancreatic adenocarcinoma",
      "PAAD"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from glandular epithelial cells of the pancreas"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 6912,
      "label": "exocrine pancreatic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4251,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4905",
          "EFO:0002618",
          "GARD:0027717",
          "MEDGEN:65917",
          "NCIT:C3850",
          "SCTID:372142002",
          "UMLS:C0235974"
        ],
        "synonyms": [
          "cancer of pancreas",
          "cancer of the pancreas",
          "exocrine cancer",
          "pancreas cancer",
          "pancreatic cancer",
          "carcinoma of exocrine pancreas",
          "carcinoma of the pancreas",
          "exocrine pancreas carcinoma",
          "pancreas carcinoma",
          "pancreatic cancer (not islets)",
          "pancreatic carcinoma, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the exocrine pancreas"
      },
      "child_count": 16,
      "reference_id": "MONDO:0005192"
    }
  ],
  "children": [
    {
      "id": 4881,
      "label": "pancreatic cystadenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7240,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4073",
          "GARD:0027622",
          "MEDGEN:66767",
          "NCIT:C3874",
          "SCTID:235966007",
          "UMLS:C0238337"
        ],
        "synonyms": [
          "cystadenocarcinoma - pancreas",
          "cystadenocarcinoma of pancreas",
          "cystadenocarcinoma of the pancreas",
          "pancreas cystadenocarcinoma",
          "pancreatic cystadenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A cystic adenocarcinoma that arises from the pancreas. It includes the acinar cell and serous cystadenocarcinoma subtypes."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002867"
    },
    {
      "id": 6284,
      "label": "pancreatic intraductal papillary-mucinous neoplasm with an associated invasive carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6102,
        6103,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8150",
          "GARD:0024028",
          "ICDO:8453/3",
          "MEDGEN:275329",
          "NCIT:C5726",
          "UMLS:C1518871"
        ],
        "synonyms": [
          "pancreatic intraductal papillary mucinous neoplasm with an associated invasive carcinoma",
          "pancreatic intraductal papillary-mucinous neoplasm with an associated invasive carcinoma",
          "pancreatic invasive intraductal papillary-mucinous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of a focal or multifocal invasive carcinomatous component. The invasive carcinoma is either colloid or ductal adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004481"
    },
    {
      "id": 6905,
      "label": "pancreatic ductal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7247,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3498",
          "DOID:3587",
          "EFO:0002517",
          "GARD:0027716",
          "ICD9:157.3",
          "MEDGEN:277490",
          "MESH:D021441",
          "NCIT:C9120",
          "UMLS:C1335302",
          "icd11.foundation:581089833"
        ],
        "synonyms": [
          "ductal adenocarcinoma of pancreas",
          "ductal adenocarcinoma of the pancreas",
          "pancreas ductal adenocarcinoma",
          "pancreas tubular adenocarcinoma",
          "pancreatic duct adenocarcinoma",
          "pancreatic ductal adenocarcinoma",
          "pancreatic ductal carcinoma",
          "pancreatic tubular adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005184"
    },
    {
      "id": 7872,
      "label": "pancreatic acinar cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6708,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5742",
          "EFO:1000439",
          "GARD:0021777",
          "MEDGEN:83540",
          "NCIT:C7977",
          "ONCOTREE:PAAC",
          "Orphanet:424046",
          "UMLS:C0279661",
          "icd11.foundation:449785448"
        ],
        "synonyms": [
          "Pancreatic acinar cell cancer",
          "acinar cell adenocarcinoma of pancreas",
          "acinar cell adenocarcinoma of the pancreas",
          "acinar cell carcinoma of pancreas",
          "acinar cell carcinoma of the pancreas",
          "carcinoma of pancreatic acinar cell",
          "pancreas acinar cell adenocarcinoma",
          "pancreatic acinar cell adenocarcinoma",
          "pancreatic acinar cell carcinoma",
          "PAAC"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the pancreas. It is characterized by the presence of relatively uniform malignant cells which form acinar patterns. It usually occurs during adulthood. Signs and symptoms include abdominal pain, weight loss, nausea, and diarrhea. It may metastasize to regional lymph nodes and the liver. A minority of patients develop lipase hypersecretion syndrome. This syndrome may be seen in patients with liver metastases and it is characterized by excessive secretion of lipase in the serum, polyarthralgia, and subcutaneous fat necrosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006346"
    },
    {
      "id": 25181,
      "label": "mucinous pancreas adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6700,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080782",
          "GARD:0028069"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pancreatic adenocarcinoma that derives from epithelial cells originating in glandular tissue, which produce mucin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850257"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 6912,
      "label": "exocrine pancreatic carcinoma"
    }
  ]
}