{
  "id": 7638,
  "label": "reproductive system neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006054",
  "properties": {
    "xrefs": [
      "EFO:1000051",
      "MEDGEN:64246",
      "NCIT:C3674",
      "UMLS:C0178830"
    ],
    "synonyms": [
      "neoplasm of reproductive system",
      "neoplasm of the reproductive system",
      "reproductive neoplasm",
      "reproductive system neoplasm",
      "reproductive system neoplasm (disease)",
      "reproductive system tumor",
      "reproductive system tumour",
      "reproductive tumor",
      "reproductive tumour",
      "tumor of reproductive system",
      "tumor of the reproductive system",
      "tumour of reproductive system",
      "tumour of the reproductive system"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A benign or malignant, primary or metastatic neoplasm affecting the male and female reproductive system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6772,
      "label": "reproductive system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:15",
          "EFO:0000512",
          "MEDGEN:61253",
          "NCIT:C4875",
          "SCTID:362968007",
          "UMLS:C0178829",
          "Wikipedia:Reproductive_system_disease"
        ],
        "synonyms": [
          "disease of reproductive system",
          "disease or disorder of reproductive system",
          "disorder of reproductive system",
          "genital disorders",
          "reproductive disease",
          "reproductive system disease",
          "reproductive system disease or disorder",
          "reproductive system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A disease involving the reproductive system."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005039"
    },
    {
      "id": 6798,
      "label": "neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21214
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14566",
          "EFO:0000616",
          "HP:0002664",
          "ICD10CM:C00-D49",
          "ICD10CM:C7A-C7A",
          "ICD10CM:C7B-C7B",
          "ICD9:140-239",
          "ICD9:239.8",
          "ICD9:239.9",
          "MEDGEN:10294",
          "MESH:D009369",
          "NCIT:C3262",
          "ONCOTREE:OTHER",
          "SCTID:55342001",
          "UMLS:C0027651"
        ],
        "synonyms": [
          "cell process disease",
          "disease of cellular proliferation",
          "neoplasia",
          "neoplasm",
          "neoplasm (disease)",
          "neoplastic disease",
          "neoplastic growth",
          "tumor",
          "tumor disease",
          "tumour",
          "tumour disease",
          "other neoplasm"
        ],
        "definition": "A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias."
      },
      "child_count": 48,
      "reference_id": "MONDO:0005070"
    }
  ],
  "children": [
    {
      "id": 2882,
      "label": "benign reproductive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6887,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050622",
          "MEDGEN:234034",
          "NCIT:C7617",
          "UMLS:C1332536"
        ],
        "synonyms": [
          "benign reproductive system neoplasm",
          "reproductive organ benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A non-metastasizing neoplasm that arises from the male or female reproductive system. Representative examples include benign prostate phyllodes tumor, benign Sertoli cell tumor, uterine corpus leiomyoma, and benign ovarian serous tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0000383"
    },
    {
      "id": 4279,
      "label": "reproductive system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:193",
          "MEDGEN:233668",
          "NCIT:C36076",
          "UMLS:C1334618"
        ],
        "synonyms": [
          "reproductive tumor",
          "reproductive tumour",
          "cancer of reproductive organ",
          "cancer of reproductive system",
          "malignant neoplasm of reproductive organ",
          "malignant neoplasm of reproductive system",
          "malignant reproductive organ neoplasm",
          "malignant reproductive system neoplasm",
          "reproductive organ cancer",
          "reproductive system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the reproductive organ"
      },
      "child_count": 16,
      "reference_id": "MONDO:0002149"
    },
    {
      "id": 7639,
      "label": "sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:192",
          "EFO:1000052",
          "ICDO:8590/1",
          "MEDGEN:104926",
          "NANDO:2200072",
          "NCIT:C3794",
          "UMLS:C0206724"
        ],
        "synonyms": [
          "Sex cord stromal tumor",
          "Sex cord-stromal neoplasm",
          "Sex cord-stromal tumor",
          "Sex cord-stromal tumor, no ICD-O subtype",
          "Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)",
          "Sex cord-stromal tumour",
          "neoplasm of sex cord",
          "sex cord neoplasm",
          "sex cord tumor",
          "sex cord tumour",
          "sex cord-stromal tumor",
          "specialised gonadal neoplasm",
          "specialised gonadal neoplasm (morphologic abnormality)",
          "specialised gonadal neoplasm NOS (morphologic abnormality)",
          "specialised gonadal tumour",
          "specialised gonadal tumour (qualifier value)",
          "specialized gonadal neoplasm (morphologic abnormality)",
          "specialized gonadal neoplasm NOS (morphologic abnormality)",
          "specialized gonadal tumor (qualifier value)",
          "tumor of sex cord",
          "tumour of sex cord",
          "malignant testicular sex cord-stromal tumor",
          "malignant testicular sex cord-stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm involving a sex cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006055"
    },
    {
      "id": 8225,
      "label": "gonadal tissue neoplasm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:104925",
          "MESH:D018309",
          "UMLS:C0206722"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Neoplasms composed of tissues of the ovary or the testis, not neoplasms located in the ovaries or testes. Gonadal tissues include germ cells, cells from the sex cord, and gonadal stromal cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006773"
    },
    {
      "id": 17888,
      "label": "pituitary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4759,
        5314,
        7638,
        8247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021253",
          "ICD9:239.7",
          "MEDGEN:19326",
          "NCIT:C3330",
          "Orphanet:304055",
          "SCTID:127024001",
          "UMLS:C0032019"
        ],
        "synonyms": [
          "neoplasm of pituitary",
          "neoplasm of pituitary gland",
          "neoplasm of the pituitary",
          "neoplasm of the pituitary gland",
          "pituitary gland neoplasm",
          "pituitary gland tumor",
          "pituitary gland tumour",
          "pituitary neoplasm",
          "pituitary tumor",
          "tumor of pituitary",
          "tumor of pituitary gland",
          "tumor of the pituitary",
          "tumor of the pituitary gland",
          "tumour of pituitary",
          "tumour of pituitary gland",
          "tumour of the pituitary",
          "tumour of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland."
      },
      "child_count": 45,
      "reference_id": "MONDO:0017611"
    },
    {
      "id": 20384,
      "label": "female reproductive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4379,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:9004",
          "MESH:D005833",
          "NCIT:C3053",
          "UMLS:C0017416"
        ],
        "synonyms": [
          "female reproductive organ neoplasm (disease)",
          "female reproductive organ tumor",
          "female reproductive organ tumour",
          "female reproductive system neoplasm",
          "female reproductive system neoplasm (disease)",
          "female reproductive system tumor",
          "female reproductive system tumour",
          "gynecologic neoplasm",
          "gynecologic tumor",
          "gynecologic tumour",
          "neoplasm of female reproductive organ",
          "neoplasm of female reproductive system",
          "neoplasm of the female reproductive system",
          "tumor of female reproductive system",
          "tumor of the female reproductive system",
          "tumour of female reproductive system",
          "tumour of the female reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign, precancerous, or malignant neoplasm that affects the female reproductive system. Representative examples include uterine corpus leiomyoma, endocervical polyp, ovarian carcinoma, cervical carcinoma, and endometrial carcinoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0021148"
    },
    {
      "id": 20463,
      "label": "prostate neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5087,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13206",
          "ICD9:600.1",
          "MEDGEN:18697",
          "NCIT:C3343",
          "ONCOTREE:PROSTATE",
          "UMLS:C0033578"
        ],
        "synonyms": [
          "neoplasm of prostate",
          "neoplasm of prostate gland",
          "neoplasm of the prostate",
          "prostate gland neoplasm",
          "prostate gland neoplasm (disease)",
          "prostate gland tumor",
          "prostate gland tumour",
          "prostate tumor",
          "prostate tumour",
          "tumor of prostate",
          "tumor of prostate gland",
          "tumor of the prostate",
          "tumour of prostate",
          "tumour of prostate gland",
          "tumour of the prostate",
          "nodular prostate",
          "prostate nodule"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the prostate gland."
      },
      "child_count": 10,
      "reference_id": "MONDO:0021259"
    },
    {
      "id": 21291,
      "label": "Brenner tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7638,
        22962
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:9000/0",
          "MEDGEN:2345",
          "MESH:D001948",
          "NCIT:C39954",
          "ONCOTREE:BTOV",
          "UMLS:C0006160"
        ],
        "synonyms": [
          "Brenner tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A usually benign tumor composed of solid and cystic nests of epithelial cells resembling transitional epithelium; it is surrounded by an abundant stromal component that is dense and fibroblastic in nature."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024235"
    },
    {
      "id": 21521,
      "label": "male reproductive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5121,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:239.5",
          "MEDGEN:42196",
          "NCIT:C3054",
          "SCTID:126895004",
          "UMLS:C0017417"
        ],
        "synonyms": [
          "Male reproductive system neoplasm",
          "Male reproductive system tumor",
          "Male reproductive system tumour",
          "male reproductive organ neoplasm",
          "male reproductive organ tumor",
          "male reproductive organ tumour",
          "neoplasm of Male reproductive system",
          "neoplasm of male reproductive organ",
          "neoplasm of the Male reproductive system",
          "tumor of Male reproductive system",
          "tumor of male reproductive organ",
          "tumor of the Male reproductive system",
          "tumour of Male reproductive system",
          "tumour of male reproductive organ",
          "tumour of the Male reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant neoplasm that affects the male reproductive system. Representative examples include benign prostate phyllodes tumor, benign testicular Sertoli cell tumor, prostatic intraepithelial neoplasia, prostate carcinoma, testicular seminoma, and testicular embryonal carcinoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0024582"
    }
  ],
  "roots": [
    {
      "id": 6772,
      "label": "reproductive system disorder"
    },
    {
      "id": 6798,
      "label": "neoplasm"
    }
  ]
}