{
  "id": 7640,
  "label": "squamous cell breast carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006056",
  "properties": {
    "xrefs": [
      "DOID:5514",
      "EFO:1000053",
      "GARD:0024277",
      "MEDGEN:233465",
      "NCIT:C5177",
      "ONCOTREE:MSCC",
      "UMLS:C1336079"
    ],
    "synonyms": [
      "breast squamous cell carcinoma",
      "primary squamous cell breast carcinoma",
      "primary squamous cell carcinoma of breast",
      "primary squamous cell carcinoma of the breast",
      "scc of breast",
      "scc of the breast",
      "squamous breast carcinoma",
      "squamous carcinoma of breast",
      "squamous carcinoma of the breast",
      "squamous cell breast carcinoma",
      "squamous cell carcinoma of breast",
      "squamous cell carcinoma of the breast",
      "metaplastic squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A rare carcinoma that arises from the breast parenchyma and is entirely composed of squamous cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 7629,
      "label": "metaplastic breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4680",
          "EFO:1000040",
          "GARD:0010804",
          "MEDGEN:277360",
          "NCIT:C5164",
          "ONCOTREE:MBC",
          "Orphanet:213531",
          "SCTID:763479005",
          "UMLS:C1334708",
          "icd11.foundation:313445809"
        ],
        "synonyms": [
          "metaplastic breast carcinoma",
          "metaplastic carcinoma of breast",
          "metaplastic carcinoma of the breast",
          "breast metaplastic carcinoma",
          "metaplastic breast cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A group of invasive breast carcinomas characterized by the presence of an adenocarcinomatous component which is admixed with a dominant component that is composed of squamous cells, spindle cells, or mesenchymal cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006043"
    }
  ],
  "children": [
    {
      "id": 5452,
      "label": "adenosquamous breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7640,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5623",
          "GARD:0023556",
          "MEDGEN:267645",
          "NCIT:C40361",
          "ONCOTREE:MASC",
          "UMLS:C1510796"
        ],
        "synonyms": [
          "adenosquamous breast carcinoma",
          "breast adenosquamous carcinoma",
          "metaplastic adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An invasive breast carcinoma characterized by the presence of tubular and glandular neoplastic cell structures, admixed with islands of neoplastic cells showing squamous differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003548"
    },
    {
      "id": 6050,
      "label": "acantholytic variant squamous cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7640
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7459",
          "GARD:0023888",
          "MEDGEN:274268",
          "NCIT:C40359",
          "UMLS:C1519485"
        ],
        "synonyms": [
          "squamous cell breast carcinoma, acantholytic variant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the breast parenchyma and is characterized by cellular discohesion resulting in a pseudoangiosarcomatous pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004229"
    },
    {
      "id": 6052,
      "label": "spindle cell variant squamous cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7640,
        20715
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7460",
          "GARD:0023889",
          "MEDGEN:274270",
          "NCIT:C40358",
          "ONCOTREE:MASCC",
          "UMLS:C1519487"
        ],
        "synonyms": [
          "squamous cell breast carcinoma, spindle cell variant",
          "metaplastic adenocarcinoma with spindle cell differentiation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of spindle-shaped malignant cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004231"
    },
    {
      "id": 6053,
      "label": "large cell keratinizing variant squamous cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6786,
        7640
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7461",
          "GARD:0023890",
          "MEDGEN:274269",
          "NCIT:C40357",
          "UMLS:C1519486"
        ],
        "synonyms": [
          "squamous cell breast carcinoma, large cell keratinizing variant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of large malignant cells that exhibit keratinization."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004232"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 7629,
      "label": "metaplastic breast carcinoma"
    }
  ]
}