{
  "id": 7648,
  "label": "ACTH-producing pituitary gland adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006068",
  "properties": {
    "xrefs": [
      "EFO:1000066",
      "GARD:0024280",
      "MEDGEN:266291",
      "NCIT:C7462",
      "UMLS:C1306214"
    ],
    "synonyms": [
      "ACTH producing pituitary gland adenoma",
      "ACTH secreting adenoma of pituitary",
      "ACTH secreting adenoma of the pituitary",
      "ACTH-producing pituitary adenoma",
      "ACTH-producing pituitary gland adenoma",
      "ACTH-secreting adenoma of pituitary",
      "ACTH-secreting adenoma of pituitary gland",
      "ACTH-secreting adenoma of the pituitary",
      "ACTH-secreting adenoma of the pituitary gland",
      "ACTHoma",
      "Corticotropinoma",
      "adrenocorticotropin producing adenoma of pituitary",
      "adrenocorticotropin producing adenoma of pituitary gland",
      "adrenocorticotropin producing adenoma of the pituitary",
      "adrenocorticotropin producing adenoma of the pituitary gland",
      "adrenocorticotropin producing pituitary adenoma",
      "adrenocorticotropin producing pituitary gland adenoma",
      "adrenocorticotropin secreting adenoma of pituitary",
      "adrenocorticotropin secreting adenoma of pituitary gland",
      "adrenocorticotropin secreting adenoma of the pituitary",
      "adrenocorticotropin secreting adenoma of the pituitary gland",
      "adrenocorticotropin secreting pituitary adenoma",
      "adrenocorticotropin secreting pituitary gland adenoma",
      "corticotroph adenoma",
      "corticotropic adenoma",
      "corticotropin secreting adenoma of the pituitary",
      "corticotropin secreting pituitary gland adenoma",
      "pituitary ACTH secreting adenoma",
      "pituitary ACTH-secreting adenoma",
      "pituitary corticotropin secreting adenoma",
      "pituitary gland ACTH-secreting adenoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenoma of the pituitary gland that produces corticotropin. The vast majority of cases are associated with Cushing disease. Clinical manifestations include truncal obesity with thin extremities, thinning of the skin, osteoporosis, and a tendency to bruise easily. Silent or hormonally non-functioning ACTH producing adenomas have also been described. They produce symptoms of a mass-related lesion."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7896,
      "label": "pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6714,
        17888
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3829",
          "EFO:1000478",
          "GARD:0019680",
          "ICDO:8272/0",
          "MEDGEN:45933",
          "MedDRA:10035079",
          "NANDO:2200095",
          "NCIT:C3329",
          "ONCOTREE:PTAD",
          "Orphanet:99408",
          "SCTID:254956000",
          "UMLS:C0032000"
        ],
        "synonyms": [
          "adenoma of pituitary",
          "adenoma of pituitary gland",
          "adenoma of the pituitary",
          "adenoma of the pituitary gland",
          "adenoma, anterior lobe pituitary gland, benign",
          "pituitary adenoma",
          "pituitary gland adenoma",
          "PTAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss."
      },
      "child_count": 18,
      "reference_id": "MONDO:0006373"
    },
    {
      "id": 23544,
      "label": "ACTH-producing pituitary gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17888
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025940",
          "MEDGEN:82997",
          "NCIT:C7909",
          "UMLS:C0278862"
        ],
        "synonyms": [
          "ACTH producing pituitary gland neoplasm",
          "ACTH-producing pituitary gland neoplasm",
          "ACTH-producing pituitary neoplasm",
          "ACTH-producing pituitary tumor",
          "ACTH-producing pituitary tumour",
          "ACTH-secreting tumor of pituitary",
          "ACTH-secreting tumor of the pituitary",
          "ACTH-secreting tumour of pituitary",
          "ACTH-secreting tumour of the pituitary",
          "adrenocorticotropin producing pituitary gland tumor",
          "adrenocorticotropin producing pituitary gland tumour",
          "adrenocorticotropin secreting neoplasm of pituitary",
          "adrenocorticotropin secreting neoplasm of the pituitary",
          "adrenocorticotropin secreting pituitary gland tumor",
          "adrenocorticotropin secreting pituitary gland tumour",
          "adrenocorticotropin secreting tumor of pituitary",
          "adrenocorticotropin secreting tumor of the pituitary",
          "adrenocorticotropin secreting tumour of pituitary",
          "adrenocorticotropin secreting tumour of the pituitary",
          "corticotropin secreting pituitary gland neoplasm",
          "pituitary corticotropin secreting neoplasm",
          "pituitary corticotropin secreting tumor",
          "pituitary corticotropin secreting tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma or carcinoma of the pituitary gland that produces corticotropin."
      },
      "child_count": 2,
      "reference_id": "MONDO:0045058"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7896,
      "label": "pituitary gland adenoma"
    },
    {
      "id": 23544,
      "label": "ACTH-producing pituitary gland neoplasm"
    }
  ]
}