{
  "id": 7652,
  "label": "adenosquamous carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006074",
  "properties": {
    "xrefs": [
      "DOID:4830",
      "EFO:1000073",
      "ICDO:8560/3",
      "MEDGEN:104901",
      "MESH:D018196",
      "NCIT:C3727",
      "SCTID:403902008",
      "UMLS:C0206623",
      "icd11.foundation:1793155313"
    ],
    "synonyms": [
      "adenosquamous carcinoma",
      "adenosquamous carcinoma (morphologic abnormality)",
      "carcinoma, adenosquamous, malignant",
      "mixed adenocarcinoma and epidermoid carcinoma",
      "mixed adenocarcinoma and epidermoid cell carcinoma",
      "mixed adenocarcinoma and squamous carcinoma",
      "mixed adenocarcinoma and squamous cell carcinoma"
    ],
    "definition": "A carcinoma composed of malignant glandular cells and malignant squamous cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 15,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    }
  ],
  "children": [
    {
      "id": 5452,
      "label": "adenosquamous breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7640,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5623",
          "GARD:0023556",
          "MEDGEN:267645",
          "NCIT:C40361",
          "ONCOTREE:MASC",
          "UMLS:C1510796"
        ],
        "synonyms": [
          "adenosquamous breast carcinoma",
          "breast adenosquamous carcinoma",
          "metaplastic adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An invasive breast carcinoma characterized by the presence of tubular and glandular neoplastic cell structures, admixed with islands of neoplastic cells showing squamous differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003548"
    },
    {
      "id": 5454,
      "label": "esophageal adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7225,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5625",
          "GARD:0023558",
          "MEDGEN:389165",
          "NCIT:C27421",
          "UMLS:C2063886"
        ],
        "synonyms": [
          "esophageal adenosquamous cancer",
          "esophageal adenosquamous carcinoma",
          "esophagus adenosquamous carcinoma",
          "oesophagus adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An esophageal carcinoma characterized by the presence of distinguishable squamous and glandular carcinomatous components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003550"
    },
    {
      "id": 5455,
      "label": "thymic adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5409,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5626",
          "GARD:0023559",
          "MEDGEN:272286",
          "NCIT:C6458",
          "UMLS:C1332171"
        ],
        "synonyms": [
          "Thymus adenosquamous carcinoma",
          "adenosquamous carcinoma of Thymus",
          "adenosquamous carcinoma of the Thymus",
          "thymic adenosquamous carcinoma",
          "thymus adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare carcinoma that arises from the thymus and is characterized by the presence of glandular and squamous carcinomatous components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003551"
    },
    {
      "id": 5458,
      "label": "Bartholin gland adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5894,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5630",
          "GARD:0023562",
          "MEDGEN:267339",
          "NCIT:C40296",
          "UMLS:C1511050"
        ],
        "synonyms": [
          "Bartholin gland adenosquamous carcinoma",
          "Bartholin's gland adenosquamous carcinoma",
          "major vestibular gland adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant glandular epithelial cells and malignant squamous epithelial cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003555"
    },
    {
      "id": 5459,
      "label": "endometrial adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7652,
        7753
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5631",
          "EFO:1001952",
          "MEDGEN:856563",
          "NCIT:C114656",
          "UMLS:C3896969"
        ],
        "synonyms": [
          "endometrial adenosquamous carcinoma",
          "endometrium adenosquamous carcinoma",
          "adenosquamous carcinoma of the endometrium",
          "endometrial adenosquamous cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare endometrial carcinoma characterized by the presence of both malignant glandular and malignant squamous cellular components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003556"
    },
    {
      "id": 5461,
      "label": "adenosquamous prostate carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3259,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5634",
          "MEDGEN:233353",
          "NCIT:C5538",
          "UMLS:C1335503"
        ],
        "synonyms": [
          "adenosquamous carcinoma of prostate",
          "adenosquamous carcinoma of the prostate",
          "prostate adenosquamous carcinoma",
          "prostate gland adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An infrequent invasive carcinoma of the prostate gland characterized by the presence of both glandular and squamous neoplastic components. It is more often located in the transitional zone of the prostate gland and it tends to rapidly metastasize to the bones."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003558"
    },
    {
      "id": 6715,
      "label": "adenosquamous lung carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7652,
        23667
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4829",
          "EFO:0000233",
          "ICD9:162.9",
          "MEDGEN:79006",
          "NCIT:C9133",
          "ONCOTREE:LUAS",
          "SCTID:707405009",
          "UMLS:C0279557"
        ],
        "synonyms": [
          "adenosquamous cell lung carcinoma",
          "adenosquamous lung cancer",
          "adenosquamous lung carcinoma",
          "lung adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An aggressive carcinoma with a poor prognosis characterized by a presence of both malignant squamous cells and glandular cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004973"
    },
    {
      "id": 7254,
      "label": "pancreatic adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7652,
        18547
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5637",
          "EFO:0006732",
          "GARD:0024211",
          "MEDGEN:277489",
          "NCIT:C5721",
          "ONCOTREE:PAASC",
          "UMLS:C1335299"
        ],
        "synonyms": [
          "adenosquamous carcinoma of pancreas",
          "adenosquamous carcinoma of the pancreas",
          "adenosquamous pancreas carcinoma",
          "pancreas adenosquamous carcinoma",
          "pancreatic adenoacanthoma",
          "pancreatic adenosquamous cancer",
          "pancreatic adenosquamous carcinoma",
          "pancreatic mixed squamous and adenocarcinoma",
          "pancreatic mucoepidermoid carcinoma",
          "PAASC"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the pancreas showing both ductal and squamous differentiation. The squamous component should represent at least 30% of the malignant cellular infiltrate. The prognosis is usually worse than that of ductal adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005614"
    },
    {
      "id": 7620,
      "label": "gastric adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7652,
        7783
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5635",
          "EFO:1000029",
          "GARD:0024272",
          "MEDGEN:272661",
          "NCIT:C5474",
          "ONCOTREE:STAS",
          "UMLS:C1333761"
        ],
        "synonyms": [
          "adenosquamous carcinoma of stomach",
          "adenosquamous carcinoma of the stomach",
          "gastric (stomach) adenosquamous cancer",
          "gastric adenosquamous carcinoma",
          "stomach adenosquamous carcinoma",
          "STAS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the stomach and is characterized by the presence of malignant cells with glandular and squamous differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006034"
    },
    {
      "id": 7698,
      "label": "cervical adenosquamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6877,
        7652,
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5636",
          "EFO:1000162",
          "GARD:0024303",
          "MEDGEN:91091",
          "NCIT:C4519",
          "ONCOTREE:CEAS",
          "SCTID:254888007",
          "UMLS:C0346202"
        ],
        "synonyms": [
          "adenosquamous cell carcinoma of cervix",
          "adenosquamous cell carcinoma of cervix uteri",
          "adenosquamous cell carcinoma of the cervix",
          "adenosquamous cell carcinoma of the cervix uteri",
          "adenosquamous cell carcinoma of the uterine cervix",
          "adenosquamous cell carcinoma of uterine cervix",
          "cervical adenosquamous cancer",
          "cervical adenosquamous carcinoma",
          "cervical adenosquamous cell carcinoma",
          "cervix adenosquamous cell carcinoma",
          "cervix uteri adenosquamous cell carcinoma",
          "uterine cervix adenosquamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An uncommon carcinoma arising from the cervix. It is composed of malignant glandular epithelial cells and malignant squamous epithelial cells."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006134"
    },
    {
      "id": 7718,
      "label": "colorectal adenosquamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7652,
        7726
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000190",
          "MEDGEN:317524",
          "NCIT:C43589",
          "UMLS:C1707437"
        ],
        "synonyms": [
          "colorectal (colon or rectal) adenosquamous cancer",
          "colorectal adenosquamous cancer",
          "colorectal adenosquamous carcinoma",
          "colorectum adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An unusual colorectal carcinoma characterized by the presence of glandular and squamous carcinomatous components. The two carcinomatous components may be admixed within the tumor, or the two may appear separately in different areas."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006157"
    },
    {
      "id": 7770,
      "label": "gallbladder adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7652,
        7773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5627",
          "EFO:1000264",
          "GARD:0024334",
          "MEDGEN:232539",
          "NCIT:C7356",
          "ONCOTREE:GBASC",
          "UMLS:C1333741"
        ],
        "synonyms": [
          "adenosquamous carcinoma of gallbladder",
          "adenosquamous carcinoma of the gallbladder",
          "adenosquamous gallbladder carcinoma",
          "gall bladder adenosquamous carcinoma",
          "gallbladder adenosquamous cancer",
          "gallbladder adenosquamous carcinoma",
          "GBASC"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the gallbladder. It is characterized by the presence of glandular and squamous malignant epithelial components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006217"
    },
    {
      "id": 7920,
      "label": "salivary gland adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7652,
        23416
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024398",
          "MEDGEN:277627",
          "NCIT:C35737",
          "UMLS:C1335894"
        ],
        "synonyms": [
          "saliva-secreting gland adenosquamous carcinoma",
          "salivary gland adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A rare, aggressive carcinoma that arises from the salivary glands. It is characterized by the presence of a squamous and a glandular epithelial component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006401"
    },
    {
      "id": 23670,
      "label": "liver adenosquamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7652,
        18553
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025991",
          "MEDGEN:858180",
          "NCIT:C118630",
          "UMLS:C3898586"
        ],
        "synonyms": [
          "liver adenosquamous cancer",
          "liver adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare carcinoma that arises from the intrahepatic bile ducts and is composed of malignant glandular cells and malignant squamous cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0056815"
    },
    {
      "id": 23673,
      "label": "skin adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:313707",
          "NCIT:C54250",
          "UMLS:C1710103"
        ],
        "synonyms": [
          "skin adenosquamous cancer",
          "skin adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An uncommon carcinoma that arises from the skin. It is characterized by the presence of malignant glandular and malignant squamous cellular components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0056818"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    }
  ]
}