{
  "id": 7659,
  "label": "anal squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006082",
  "properties": {
    "xrefs": [
      "DOID:5525",
      "EFO:1000081",
      "GARD:0024286",
      "MEDGEN:237257",
      "NCIT:C9161",
      "ONCOTREE:ANSC",
      "UMLS:C1412036"
    ],
    "synonyms": [
      "anal squamous cell cancer",
      "anal squamous cell carcinoma",
      "anus squamous cell carcinoma",
      "epidermoid anal carcinoma",
      "epidermoid carcinoma of anus",
      "epidermoid carcinoma of the anus",
      "squamous cell anal carcinoma",
      "squamous cell carcinoma - anus",
      "squamous cell carcinoma of anus",
      "squamous cell carcinoma of the anus",
      "ANSC"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 5158,
      "label": "anal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4054,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4908",
          "GARD:0027634",
          "MEDGEN:76006",
          "NCIT:C9291",
          "SCTID:448315008",
          "UMLS:C0279637"
        ],
        "synonyms": [
          "Ca anus",
          "anal cancer",
          "cancer of anus",
          "cancer of the anus",
          "anal carcinoma",
          "anus carcinoma",
          "carcinoma of anus",
          "carcinoma of the anus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the anus"
      },
      "child_count": 8,
      "reference_id": "MONDO:0003199"
    },
    {
      "id": 18545,
      "label": "squamous cell carcinoma of rectum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7726,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5528",
          "GARD:0021770",
          "MEDGEN:235534",
          "NCIT:C5554",
          "Orphanet:424002",
          "SCTID:766979005",
          "UMLS:C1335690"
        ],
        "synonyms": [
          "rectal squamous carcinoma",
          "rectal squamous cell cancer",
          "rectal squamous cell carcinoma",
          "rectum squamous cell carcinoma",
          "squamous carcinoma of rectum",
          "squamous carcinoma of the rectum",
          "squamous cell carcinoma of rectum",
          "squamous cell carcinoma of the rectum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A very rare rectal carcinoma characterized by the presence of a malignant squamous cell infiltrate."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018515"
    }
  ],
  "children": [
    {
      "id": 3684,
      "label": "anal margin squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        4946,
        7659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12239",
          "GARD:0022948",
          "ICD10CM:C44.520",
          "ICD9:173.5",
          "MEDGEN:278071",
          "NCIT:C6925",
          "SCTID:255084004",
          "UMLS:C1412037"
        ],
        "synonyms": [
          "anal margin squamous cell carcinoma",
          "perianal skin squamous cell carcinoma",
          "squamous cell carcinoma of anal margin",
          "squamous cell carcinoma of the anal margin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the perianal skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001470"
    },
    {
      "id": 5959,
      "label": "anus basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        7659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7174",
          "GARD:0023839",
          "MEDGEN:79125",
          "NCIT:C8256",
          "UMLS:C0280470"
        ],
        "synonyms": [
          "anal basaloid carcinoma",
          "anus basaloid squamous cell carcinoma",
          "basaloid carcinoma of anus",
          "basaloid carcinoma of the anus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An anal squamous cell carcinoma characterized by the presence of malignant cells with hyperchromatic nuclei and peripheral nuclear palisading."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004130"
    },
    {
      "id": 5960,
      "label": "anal verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7659,
        21745,
        23208
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7175",
          "GARD:0023840",
          "MEDGEN:231066",
          "NCIT:C7470",
          "UMLS:C1332278"
        ],
        "synonyms": [
          "anal Buschke-Lowenstein tumor",
          "anal Buschke-Lowenstein tumour",
          "anal giant (malignant) condyloma",
          "anal verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A large, well differentiated squamous cell carcinoma with a cauliflower-like appearance, characterized by the presence of an exophytic and endophytic growth pattern. Morphologically, there is papillomatosis and acanthosis present, however cytologically the neoplastic squamous cells have a benign appearance. Dysplastic changes are minimal. It does not respond to conservative treatment and it is regarded by many authors as an intermediate lesion between condyloma acuminatum and squamous cell carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004131"
    },
    {
      "id": 5961,
      "label": "anal canal squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7659,
        8521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7177",
          "GARD:0021774",
          "MEDGEN:233979",
          "NCIT:C7469",
          "Orphanet:424019",
          "UMLS:C1332262",
          "icd11.foundation:585238371"
        ],
        "synonyms": [
          "anal canal squamous cell carcinoma",
          "squamous cell carcinoma of the anal canal"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the mucosa of the anal canal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004132"
    }
  ],
  "roots": [
    {
      "id": 5158,
      "label": "anal carcinoma"
    },
    {
      "id": 18545,
      "label": "squamous cell carcinoma of rectum"
    }
  ]
}