{
  "id": 7679,
  "label": "bile duct adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006108",
  "properties": {
    "xrefs": [
      "DOID:5381",
      "EFO:1000123",
      "ICDO:8160/0",
      "MEDGEN:918",
      "MESH:D002759",
      "NCIT:C2942",
      "SCTID:424091006",
      "UMLS:C0008309"
    ],
    "synonyms": [
      "CHOLANGIOMA, benign",
      "Cholangioadenoma",
      "Cholangioma",
      "Hepatocholangiocellular adenoma",
      "Hepatocholangioma",
      "adenoma of bile duct",
      "adenoma of the bile duct",
      "bile duct adenoma",
      "bile duct adenoma (morphologic abnormality)"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign, well-demarcated polypoid neoplasm arising from the bile duct epithelium. According to the growth pattern, it is classified as tubular, papillary, or tubulopapillary. Adenomas arising from the extrahepatic bile ducts usually produce symptoms related to biliary obstruction."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7737,
      "label": "digestive system adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6714,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4147",
          "EFO:1000217",
          "MEDGEN:184920",
          "NCIT:C36207",
          "UMLS:C0948101"
        ],
        "synonyms": [
          "digestive system adenoma",
          "digestive tract adenoma",
          "gastrointestinal adenoma"
        ],
        "definition": "A sporadic or less frequently familial neoplasm, arising from the glandular epithelium of the stomach, small intestine, biliary tract, colon, and rectum. It is a polypoid or flat circumscribed lesion. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. The frequency of malignant transformation depends on the size of the lesion and the degree of dysplasia. Larger adenomas with severe dysplastic changes (sometimes called carcinoma in situ) carry a higher risk of progressing to invasive adenocarcinoma. Gastrointestinal adenomas may present as solitary or multifocal lesions. Familial adenomas tend to be multifocal and carry a higher risk of malignant transformation."
      },
      "child_count": 12,
      "reference_id": "MONDO:0006180"
    },
    {
      "id": 20714,
      "label": "bile duct neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4900,
        6998
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:14114",
          "MESH:D001650",
          "NCIT:C2898",
          "UMLS:C0005396"
        ],
        "synonyms": [
          "bile duct neoplasm",
          "bile duct neoplasm (disease)",
          "bile duct tumor",
          "bile duct tumour",
          "intrahepatic and extrahepatic bile duct neoplasm",
          "intrahepatic and extrahepatic bile duct tumor",
          "intrahepatic and extrahepatic bile duct tumour",
          "neoplasm of bile duct",
          "tumor of bile duct",
          "tumour of bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the intrahepatic or extrahepatic bile ducts. Representative examples of benign neoplasms include bile duct adenoma and extrahepatic bile duct lipoma. Representative examples of malignant neoplasms include intrahepatic and extrahepatic cholangiocarcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0021662"
    }
  ],
  "children": [
    {
      "id": 5348,
      "label": "bile duct cystadenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4467,
        7679
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5384",
          "ICDO:8161/0",
          "MEDGEN:90756",
          "NCIT:C4129",
          "UMLS:C0334285"
        ],
        "synonyms": [
          "bile duct cystadenoma",
          "bile duct cystadenoma (morphologic abnormality)",
          "bile duct mucinous cystic neoplasm",
          "cystadenoma of bile duct",
          "cystadenoma of the bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial, usually multiloculated neoplasm arising from the intrahepatic or extrahepatic bile ducts. It occurs predominantly in females. Signs and symptoms include abdominal mass, abdominal pain, and jaundice. Morphologically, the cystic spaces are lined by columnar epithelium and contain mucinous or serous fluid."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003420"
    },
    {
      "id": 5370,
      "label": "intrahepatic bile duct adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7679
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5437",
          "MEDGEN:272250",
          "NCIT:C7126",
          "UMLS:C1331535"
        ],
        "synonyms": [
          "adenoma of the intrahepatic bile duct",
          "adenoma, HEPATOCHOLANGIOCELLULAR, benign",
          "intrahepatic bile duct adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare adenoma that arises from the intrahepatic biliary tree."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003444"
    },
    {
      "id": 5371,
      "label": "extrahepatic bile duct adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7679,
        20541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5438",
          "MEDGEN:233098",
          "NCIT:C5857",
          "UMLS:C1331534",
          "icd11.foundation:1322471141"
        ],
        "synonyms": [
          "adenoma of extrahepatic bile duct",
          "adenoma of the extrahepatic bile duct",
          "extrahepatic bile duct adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma that arises from the extrahepatic bile ducts. It is classified as papillary, tubular, or tubulopapillary."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003445"
    }
  ],
  "roots": [
    {
      "id": 7737,
      "label": "digestive system adenoma"
    },
    {
      "id": 20714,
      "label": "bile duct neoplasm"
    }
  ]
}