{
  "id": 7683,
  "label": "blast phase chronic myelogenous leukemia, BCR-ABL1 positive",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006115",
  "properties": {
    "xrefs": [
      "EFO:1000131",
      "GARD:0024298",
      "MEDGEN:2281",
      "MESH:D001752",
      "NCIT:C9110",
      "SCTID:413656006",
      "UMLS:C0005699"
    ],
    "synonyms": [
      "blast crisis",
      "blast phase CML",
      "blast phase chronic granulocytic leukaemia",
      "blast phase chronic granulocytic leukemia",
      "blast phase chronic myelocytic leukaemia",
      "blast phase chronic myelocytic leukemia",
      "blast phase chronic myelogenous leukaemia",
      "blast phase chronic myelogenous leukemia",
      "blast phase chronic myeloid leukaemia",
      "blast phase chronic myeloid leukemia",
      "blastic phase CML",
      "blastic phase chronic granulocytic leukaemia",
      "blastic phase chronic granulocytic leukemia",
      "blastic phase chronic myelocytic leukaemia",
      "blastic phase chronic myelocytic leukemia",
      "blastic phase chronic myelogenous leukaemia",
      "blastic phase chronic myelogenous leukemia",
      "blastic phase chronic myeloid leukaemia",
      "blastic phase chronic myeloid leukemia",
      "blast crises",
      "blast phase",
      "blast phases",
      "crises, blast",
      "crisis, blast",
      "phase, blast",
      "phases, blast"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An advanced phase of chronic myelogenous leukemia. It is characterized by: 1. the presence of blasts in the peripheral blood or bone marrow that are at least 20% of the peripheral blood white cells or of the nucleated cells in the bone marrow respectively, or 2. an extramedullary proliferation of blasts, and/or 3. when there are large aggregates and clusters of blasts in the bone marrow biopsy specimen (adapted from WHO, 2001)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 13067,
      "label": "chronic myelogenous leukemia, BCR-ABL1 positive",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6429,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081088",
          "DOID:8552",
          "EFO:0000339",
          "GARD:0006105",
          "ICD9:205.1",
          "ICDO:9863/3",
          "ICDO:9875/3",
          "MEDGEN:75993",
          "MedDRA:10009013",
          "NANDO:2200013",
          "NCIT:C3174",
          "OMIM:608232",
          "ONCOTREE:CML",
          "Orphanet:521",
          "UMLS:C0279543"
        ],
        "synonyms": [
          "BCR-ABL Positive chronic myelogenous leukaemia",
          "BCR-ABL Positive chronic myelogenous leukemia",
          "CML",
          "CML - chronic myelogenous leukaemia",
          "CML - chronic myelogenous leukemia",
          "chronic granulocytic leukemia",
          "chronic myelocytic leukaemia",
          "chronic myelocytic leukemia",
          "chronic myelogenous leukaemia (CML)",
          "chronic myelogenous leukemia",
          "chronic myelogenous leukemia (CML)",
          "chronic myelogenous leukemia, BCR-ABL1 Positive",
          "chronic myelogenous leukemias",
          "chronic myeloid leukemia",
          "hematopoeitic - chronic myelocytic leukaemia (CML)",
          "hematopoeitic - chronic myelocytic leukemia (CML)",
          "leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation",
          "leukemia, chronic myeloid, Philadelphia chromosome positive, somatic",
          "myeloid leukemia, chronic",
          "leukemia, chronic myelogenous",
          "leukemia, chronic myeloid",
          "leukemia, chronic myeloid, atypical"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival."
      },
      "child_count": 6,
      "reference_id": "MONDO:0011996"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 13067,
      "label": "chronic myelogenous leukemia, BCR-ABL1 positive"
    }
  ]
}