{
  "id": 7688,
  "label": "C-cell hyperplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006120",
  "properties": {
    "xrefs": [
      "EFO:1000147",
      "MEDGEN:90975",
      "NCIT:C46100",
      "UMLS:C0342190"
    ],
    "synonyms": [
      "C-cell hyperplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Neoplastic or reactive proliferation of the C-cells in the thyroid gland. The neoplastic C-cell hyperplasia is associated with familial medullary thyroid gland carcinoma and multiple endocrine neoplasia type II and IIB. Morphologically, it is characterized by the presence of clusters of intrafollicular C-cells with atypical cytologic features. The reactive C-cell hyperplasia is also known as physiological or secondary C-cell hyperplasia and it is associated with conditions that cause hypercalcemia (e.g., hyperparathyroidism)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5187,
      "label": "thyroid gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:50",
          "EFO:1000627",
          "ICD10CM:E00-E07",
          "ICD9:240-246",
          "ICD9:246.8",
          "ICD9:246.9",
          "MEDGEN:1378579",
          "MESH:D013959",
          "NCIT:C26893",
          "SCTID:14304000",
          "UMLS:C4317107",
          "Wikipedia:Thyroid_disease"
        ],
        "synonyms": [
          "disease of thyroid gland",
          "disease or disorder of thyroid gland",
          "disorder of thyroid gland",
          "thyroid disease",
          "thyroid gland disease",
          "thyroid gland disease or disorder",
          "thyroid gland diseases",
          "thyroid gland disorder",
          "thyroid gland disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the thyroid gland."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003240"
    },
    {
      "id": 6775,
      "label": "hyperplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23519
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000536",
          "MEDGEN:43784",
          "MESH:D006965",
          "NCIT:C3113",
          "UMLS:C0020507"
        ],
        "synonyms": [
          "hyperplasia",
          "hyperplastic"
        ],
        "definition": "An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005043"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5187,
      "label": "thyroid gland disorder"
    },
    {
      "id": 6775,
      "label": "hyperplasia"
    }
  ]
}