{ "id": 7694, "label": "central nervous system neoplasm", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0006130", "properties": { "xrefs": [ "EFO:1000158", "MEDGEN:88335", "NCIT:C9293", "UMLS:C0085136" ], "synonyms": [ "CNS neoplasm", "CNS tumor", "CNS tumour", "brain/spinal cord tumor", "brain/spinal cord tumour", "central nervous system neoplasm", "central nervous system neoplasm (disease)", "central nervous system tumor", "central nervous system tumour", "neoplasm of CNS", "neoplasm of central nervous system", "neoplasm of the central nervous system", "tumor of CNS", "tumor of central nervous system", "tumor of the CNS", "tumor of the central nervous system", "tumour of CNS", "tumour of central nervous system", "tumour of the CNS", "tumour of the central nervous system" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia." }, "isLeaf": false, "isRoot": false, "child_count": 10, "parents": [ { "id": 4657, "label": "central nervous system disorder", "isLeaf": false, "isRoot": false, "parents": [ 6799 ], "type_id": 0, "properties": { "xrefs": [ "DOID:331", "EFO:0009386", "MEDGEN:892343", "MESH:D002493", "NCIT:C2934", "SCTID:23853001", "UMLS:C4021765" ], "synonyms": [ "CNS disorder", "central nervous disease", "central nervous system disease", "central nervous system disease or disorder", "central nervous system disorder", "disease of central nervous system", "disease of the central nervous system", "disease or disorder of central nervous system", "disorder of central nervous system" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A disease involving the central nervous system." }, "child_count": 19, "reference_id": "MONDO:0002602" }, { "id": 20456, "label": "nervous system neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6798, 6799 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:45046", "NCIT:C3268", "UMLS:C0027766" ], "synonyms": [ "neoplasm of nervous system", "neoplasm of the nervous system", "nervous system neoplasm (disease)", "nervous system neoplasms", "nervous system tumor", "nervous system tumour", "tumor of nervous system", "tumor of the nervous system", "tumour of nervous system", "tumour of the nervous system" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A neoplasm (disease) that involves the nervous system." }, "child_count": 14, "reference_id": "MONDO:0021248" } ], "children": [ { "id": 3033, "label": "central nervous system organ benign neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 3049, 7694 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060090", "MEDGEN:488882", "NCIT:C188049", "UMLS:C0347509" ], "synonyms": [ "central nervous system benign neoplasm" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A benign neoplasm that involves the central nervous system." }, "child_count": 26, "reference_id": "MONDO:0000628" }, { "id": 4464, "label": "autonomic nervous system neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 3525, 3627, 7694 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2621", "MEDGEN:231389", "NCIT:C5112", "UMLS:C1332356" ], "synonyms": [ "autonomic nervous system neoplasm", "autonomic nervous system neoplasm (disease)", "autonomic nervous system neoplasms", "autonomic nervous system tumor", "autonomic nervous system tumour", "neoplasm of autonomic nervous system", "neoplasm of the autonomic nervous system", "tumor of autonomic nervous system", "tumor of the autonomic nervous system", "tumour of autonomic nervous system", "tumour of the autonomic nervous system" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Benign and malignant neoplasms which arise from or directly involve the central or peripheral elements of the autonomic nervous system." }, "child_count": 9, "reference_id": "MONDO:0002366" }, { "id": 4691, "label": "optic nerve neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4268, 4684, 7694 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3419", "EFO:1001073", "ICD9:239.7", "MEDGEN:101181", "MESH:D019574", "NCIT:C4801", "SCTID:395505000", "UMLS:C0524802" ], "synonyms": [ "cranial nerve II neoplasm", "cranial nerve II neoplasm (disease)", "cranial nerve II neoplasms", "cranial nerve II tumor", "cranial nerve II tumour", "neoplasm of cranial nerve II", "neoplasm of optic nerve", "neoplasm of second cranial nerve", "neoplasm of the optic nerve", "neoplasm of the second cranial nerve", "neoplasms, optic nerve", "neoplasms, second cranial nerve", "optic nerve neoplasm", "optic nerve neoplasms", "optic nerve tumor", "optic nerve tumour", "second cranial nerve neoplasm", "second cranial nerve neoplasms", "second cranial nerve tumor", "second cranial nerve tumour", "tumor of cranial nerve II", "tumor of optic nerve", "tumor of second cranial nerve", "tumor of the optic nerve", "tumor of the second cranial nerve", "tumour of cranial nerve II", "tumour of second cranial nerve", "tumour of the optic nerve", "tumour of the second cranial nerve" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0024458", "name": "disorder of visual system" } ], "definition": "Benign and malignant neoplasms which arise from or metastasize to the optic or second cranial nerve which extends from the optic disk of the eye and joins the optic chiasm. Clinical features may include visual loss, proptosis, and local pain. The majority of optic nerve tumors or optic gliomas." }, "child_count": 9, "reference_id": "MONDO:0002640" }, { "id": 4753, "label": "central nervous system cancer", "isLeaf": false, "isRoot": false, "parents": [ 7479, 7694 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3620", "EFO:0000326", "GARD:0027614", "ICD9:239.7", "MEDGEN:87593", "MESH:D016543", "NANDO:2100007", "NCIT:C4627", "SCTID:126951006", "UMLS:C0348374" ], "synonyms": [ "CNS neoplasm", "central nervous system tumor", "central nervous system tumour", "CNS cancer", "CNS malignant neoplasms", "CNS neoplasms, malignant", "cancer of CNS", "cancer of central nervous system", "cancer of the CNS", "cancer of the central nervous system", "central nervous system cancer", "central nervous system neoplasms, malignant", "central nervous system tumours", "malignant CNS neoplasm", "malignant CNS neoplasms", "malignant CNS tumor", "malignant CNS tumour", "malignant central nervous system neoplasm", "malignant central nervous system tumor", "malignant central nervous system tumour", "malignant neoplasm of CNS", "malignant neoplasm of central nervous system", "malignant neoplasm of the CNS", "malignant neoplasm of the central nervous system", "malignant tumor of CNS", "malignant tumor of central nervous system", "malignant tumor of the CNS", "malignant tumor of the central nervous system", "malignant tumour of CNS", "malignant tumour of central nervous system", "malignant tumour of the CNS", "malignant tumour of the central nervous system" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A malignant neoplasm involving the central nervous system" }, "child_count": 40, "reference_id": "MONDO:0002714" }, { "id": 4999, "label": "central nervous system germ cell tumor", "isLeaf": false, "isRoot": false, "parents": [ 7694, 18334 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4439", "GARD:0023321", "MEDGEN:232040", "NCIT:C5461", "UMLS:C1332880" ], "synonyms": [ "CNS germ cell neoplasm", "CNS germ cell tumor", "CNS germ cell tumour", "central nervous system germ cell neoplasm", "central nervous system germ cell tumor", "central nervous system rare germ cell tumor", "central nervous system rare germ cell tumour", "germ cell neoplasm of CNS", "germ cell neoplasm of central nervous system", "germ cell neoplasm of the CNS", "germ cell neoplasm of the central nervous system", "germ cell tumor of CNS", "germ cell tumor of central nervous system", "germ cell tumor of the CNS", "germ cell tumor of the central nervous system", "germ cell tumour of CNS", "germ cell tumour of central nervous system", "germ cell tumour of the central nervous system" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma." }, "child_count": 12, "reference_id": "MONDO:0003000" }, { "id": 5530, "label": "central nervous system hematopoietic neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 7694, 23467 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5772", "GARD:0023597", "MEDGEN:234101", "NCIT:C5503", "UMLS:C1332882" ], "synonyms": [ "CNS haematopoietic neoplasm", "CNS haematopoietic tumour", "CNS hematopoietic neoplasm", "CNS hematopoietic tumor", "central nervous system haematopoietic and lymphoid system neoplasm", "central nervous system haematopoietic neoplasms", "central nervous system haematopoietic tumour", "central nervous system hematopoietic and lymphoid system neoplasm", "central nervous system hematopoietic neoplasm", "central nervous system hematopoietic neoplasms", "central nervous system hematopoietic tumor", "haematopoietic and lymphoid system neoplasm of central nervous system", "haematopoietic neoplasm of CNS", "haematopoietic neoplasm of central nervous system", "haematopoietic neoplasm of the CNS", "haematopoietic neoplasm of the central nervous system", "haematopoietic tumour of central nervous system", "haematopoietic tumour of the central nervous system", "hematopoietic and lymphoid system neoplasm of central nervous system", "hematopoietic neoplasm of CNS", "hematopoietic neoplasm of central nervous system", "hematopoietic neoplasm of the CNS", "hematopoietic neoplasm of the central nervous system", "hematopoietic tumor of central nervous system", "hematopoietic tumor of the central nervous system", "lymphomas and hemopoietic neoplasms of CNS", "lymphomas and hemopoietic neoplasms of the CNS", "central nervous system hematologic cancer" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "A primary or metastatic neoplasm of hematopoietic origin that affects the brain, meninges, or spinal cord. Representative examples include Hodgkin and non-Hodgkin lymphomas, histiocytic tumors, and leukemias." }, "child_count": 8, "reference_id": "MONDO:0003641" }, { "id": 7373, "label": "epidural abscess", "isLeaf": true, "isRoot": false, "parents": [ 6939, 7694, 21534 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11387", "EFO:0007260", "GARD:0024227", "MEDGEN:82848", "MESH:D020802", "SCTID:61974008", "UMLS:C0270629" ], "synonyms": [ "extradural intraspinal abscess", "intraspinal epidural abscess", "intraspinal extradural abscess", "spinal epidural abscess", "spinal epidural abscess (disorder)", "spinal extradural abscess" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Circumscribed collections of suppurative material occurring in the spinal or intracranial epidural space. The majority of epidural abscesses occur in the spinal canal and are associated with osteomyelitis of a vertebral body; analgesia, epidural; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, urinary incontinence, and fecal incontinence. Cranial epidural abscesses are usually associated with osteomyelitis of a cranial bone, sinusitis, or otitis media. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65(2):209-12)" }, "child_count": 0, "reference_id": "MONDO:0005752" }, { "id": 17192, "label": "tumor of meninges", "isLeaf": false, "isRoot": false, "parents": [ 7694 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0003851", "GARD:0020737", "ICD9:239.7", "MEDGEN:44353", "MedDRA:10061282", "NCIT:C3229", "ONCOTREE:MNGT", "Orphanet:252025", "SCTID:126965008", "UMLS:C0025284" ], "synonyms": [ "meningeal cluster neoplasm", "meningeal cluster neoplasm (disease)", "meningeal cluster rare nervous system tumor", "meningeal cluster rare nervous system tumour", "meningeal cluster tumor", "meningeal cluster tumour", "meningeal neoplasm", "meningeal neoplasms", "meningeal tumor", "meningeal tumour", "meninges neoplasm", "meninges tumor", "meninges tumour", "neoplasm of meningeal cluster", "neoplasm of meninges", "neoplasm of the meninges", "tumor of meningeal cluster", "tumor of meninges", "tumor of the meninges", "tumour of meningeal cluster", "tumour of the meninges", "meningothelial tumor", "meningothelial tumour" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A benign or malignant neoplasm that affects the meninges. The majority of the neoplasms arise from meningothelial cells and are called meningiomas. Non-meningothelial cell neoplasms include mesenchymal, non-meningothelial tumors, hemangiopericytomas, and melanocytic lesions." }, "child_count": 5, "reference_id": "MONDO:0016743" }, { "id": 20429, "label": "brain neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 7209, 7694 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0003833", "MEDGEN:14216", "NCIT:C2907", "UMLS:C0006118" ], "synonyms": [ "brain neoplasm (disease)", "brain neoplasms", "brain tumor", "brain tumour", "neoplasm of brain", "neoplasm of the brain", "tumor of brain", "tumor of the Brain", "tumour of brain", "tumour of the Brain" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A neoplasm (disease) that involves the brain." }, "child_count": 34, "reference_id": "MONDO:0021211" }, { "id": 20444, "label": "spinal cord neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4611, 7694 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0003828", "MEDGEN:11551", "MESH:D013120", "NCIT:C3381", "UMLS:C0037930" ], "synonyms": [ "neoplasm of spinal cord", "neoplasm of the spinal cord", "spinal cord neoplasm (disease)", "spinal cord tumor", "spinal cord tumour", "tumor of spinal cord", "tumor of the spinal cord", "tumour of spinal cord", "tumour of the spinal cord" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A neoplasm (disease) that involves the spinal cord." }, "child_count": 16, "reference_id": "MONDO:0021234" } ], "roots": [ { "id": 4657, "label": "central nervous system disorder" }, { "id": 20456, "label": "nervous system neoplasm" } ] }