{
  "id": 7697,
  "label": "cervical adenoid cystic carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006133",
  "properties": {
    "xrefs": [
      "DOID:4867",
      "EFO:1000161",
      "GARD:0020498",
      "MEDGEN:232337",
      "NCIT:C6346",
      "ONCOTREE:CACC",
      "Orphanet:213823",
      "UMLS:C1332911"
    ],
    "synonyms": [
      "adenoid cystic carcinoma of cervix",
      "adenoid cystic carcinoma of cervix uteri",
      "adenoid cystic carcinoma of the cervix",
      "adenoid cystic carcinoma of the cervix uteri",
      "adenoid cystic carcinoma of the uterine cervix",
      "adenoid cystic carcinoma of uterine cervix",
      "cervical adenoid cystic cancer",
      "cervical adenoid cystic carcinoma",
      "cervix uteri adenoid cystic carcinoma",
      "uterine cervix adenoid cystic carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A rare carcinoma that arises from the cervix. It is characterized by the presence of cystic spaces surrounded by palisaded epithelial cells. The cystic spaces contain eosinophilic hyaline material or mucin. Nuclear pleomorphism, necrotic changes, and a high mitotic rate are also present."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6713,
      "label": "adenoid cystic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080202",
          "EFO:0000231",
          "GARD:0005743",
          "ICDO:8200/3",
          "MEDGEN:41382",
          "MESH:D003528",
          "NCIT:C2970",
          "ONCOTREE:ACYC",
          "UMLS:C0010606",
          "icd11.foundation:2127202862"
        ],
        "synonyms": [
          "adenocystic carcinoma",
          "adenoid cystic cancer",
          "adenoid cystic carcinoma",
          "cylindroid adenocarcinoma",
          "cribriform carcinoma",
          "cylindroma"
        ],
        "definition": "A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic."
      },
      "child_count": 17,
      "reference_id": "MONDO:0004971"
    },
    {
      "id": 6877,
      "label": "cervical adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3702",
          "EFO:0001416",
          "GARD:0020488",
          "MEDGEN:79024",
          "NCIT:C4029",
          "ONCOTREE:CEAD",
          "Orphanet:213772",
          "SCTID:254887002",
          "UMLS:C0279672",
          "icd11.foundation:261293318"
        ],
        "synonyms": [
          "adenocarcinoma - cervix",
          "adenocarcinoma of cervix",
          "adenocarcinoma of cervix uteri",
          "adenocarcinoma of the cervix",
          "adenocarcinoma of the cervix uteri",
          "adenocarcinoma of the uterine cervix",
          "adenocarcinoma of uterine cervix",
          "cervical adenocarcinoma",
          "cervix adenocarcinoma",
          "cervix uteri adenocarcinoma",
          "uterine cervix adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the cervical epithelium. It accounts for approximately 15% of invasive cervical carcinomas. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors. Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement. Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type."
      },
      "child_count": 20,
      "reference_id": "MONDO:0005153"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6713,
      "label": "adenoid cystic carcinoma"
    },
    {
      "id": 6877,
      "label": "cervical adenocarcinoma"
    }
  ]
}