{
  "id": 7706,
  "label": "cervical squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006143",
  "properties": {
    "xrefs": [
      "DOID:3744",
      "EFO:1000172",
      "GARD:0020487",
      "MEDGEN:124644",
      "NCIT:C4028",
      "ONCOTREE:CESC",
      "Orphanet:213767",
      "SCTID:254886006",
      "UMLS:C0279671",
      "icd11.foundation:1544785014"
    ],
    "synonyms": [
      "cervical squamous cell cancer",
      "cervical squamous cell carcinoma",
      "cervix squamous cell carcinoma",
      "cervix uteri squamous cell carcinoma",
      "squamous cell carcinoma of cervix",
      "squamous cell carcinoma of cervix uteri",
      "squamous cell carcinoma of the cervix",
      "squamous cell carcinoma of the cervix uteri",
      "squamous cell carcinoma of the uterine cervix",
      "squamous cell carcinoma of uterine cervix",
      "squamous cervical cancer",
      "uterine cervix squamous cell carcinoma",
      "CESC"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 6855,
      "label": "cervical carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4978,
        6929
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2893",
          "EFO:0001061",
          "MEDGEN:86222",
          "NCIT:C9039",
          "SCTID:285432005",
          "UMLS:C0302592",
          "icd11.foundation:1743710977"
        ],
        "synonyms": [
          "cancer of cervix",
          "cancer of the cervix",
          "cancer of the uterine cervix",
          "cancer of uterine cervix",
          "cervical cancer",
          "cervical cancer, NOS",
          "cervix cancer",
          "uterine cervix cancer",
          "carcinoma of cervix",
          "carcinoma of cervix uteri",
          "carcinoma of the cervix",
          "carcinoma of the cervix uteri",
          "carcinoma of the uterine cervix",
          "carcinoma of uterine cervix",
          "cervical carcinoma",
          "cervix carcinoma",
          "cervix uteri carcinoma",
          "uterine cervix carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005131"
    }
  ],
  "children": [
    {
      "id": 4795,
      "label": "cervical verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7597,
        7706,
        16844
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3743",
          "GARD:0023237",
          "MEDGEN:275713",
          "NCIT:C40190",
          "UMLS:C1516435"
        ],
        "synonyms": [
          "cervical verrucous carcinoma",
          "uterine cervix verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A highly differentiated variant of cervical squamous cell carcinoma characterized by the presence of a warty surface and stromal invasion with pushing borders. The malignant cells have abundant cytoplasm and minimal nuclear atypia. Koilocytosis is not present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002761"
    },
    {
      "id": 5923,
      "label": "cervical basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7046",
          "GARD:0023812",
          "MEDGEN:267027",
          "NCIT:C40189",
          "UMLS:C1511063"
        ],
        "synonyms": [
          "cervical basaloid carcinoma",
          "cervical basaloid squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive variant of cervical squamous cell carcinoma characterized by the presence of nests of malignant basaloid squamous cells with scant amount of cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004088"
    },
    {
      "id": 6060,
      "label": "cervical keratinizing squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6786,
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7483",
          "GARD:0023894",
          "MEDGEN:309255",
          "NCIT:C40187",
          "UMLS:C1517658"
        ],
        "synonyms": [
          "cervical keratinizing squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A variant of cervical squamous cell carcinoma characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004239"
    },
    {
      "id": 6113,
      "label": "cervical lymphoepithelioma-like carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5471,
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7598",
          "GARD:0023918",
          "MEDGEN:308946",
          "NCIT:C40193",
          "UMLS:C1516418"
        ],
        "synonyms": [
          "cervical lymphoepithelioma-like carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A variant of cervical squamous cell carcinoma characterized by the presence of islands of cells with uniform, vesicular nuclei and prominent nucleoli and a dense lymphocytic infiltrate."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004296"
    },
    {
      "id": 6222,
      "label": "cervical non-keratinizing squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7961",
          "GARD:0023990",
          "MEDGEN:309426",
          "NCIT:C40188",
          "UMLS:C1518366"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A variant of cervical squamous cell carcinoma characterized by the presence of polygonal squamous cells. Intercellular bridges and cytoplasmic keratinization may be present, but keratin pearls are absent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004413"
    },
    {
      "id": 6351,
      "label": "microinvasive cervical squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8409",
          "GARD:0024064",
          "MEDGEN:272565",
          "NCIT:C36094",
          "UMLS:C1333370"
        ],
        "synonyms": [
          "early invasive cervical squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A cervical squamous cell carcinoma with minimal stromal invasion. The risk of lymph node metastasis is low."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004552"
    },
    {
      "id": 7698,
      "label": "cervical adenosquamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6877,
        7652,
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5636",
          "EFO:1000162",
          "GARD:0024303",
          "MEDGEN:91091",
          "NCIT:C4519",
          "ONCOTREE:CEAS",
          "SCTID:254888007",
          "UMLS:C0346202"
        ],
        "synonyms": [
          "adenosquamous cell carcinoma of cervix",
          "adenosquamous cell carcinoma of cervix uteri",
          "adenosquamous cell carcinoma of the cervix",
          "adenosquamous cell carcinoma of the cervix uteri",
          "adenosquamous cell carcinoma of the uterine cervix",
          "adenosquamous cell carcinoma of uterine cervix",
          "cervical adenosquamous cancer",
          "cervical adenosquamous carcinoma",
          "cervical adenosquamous cell carcinoma",
          "cervix adenosquamous cell carcinoma",
          "cervix uteri adenosquamous cell carcinoma",
          "uterine cervix adenosquamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An uncommon carcinoma arising from the cervix. It is composed of malignant glandular epithelial cells and malignant squamous epithelial cells."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006134"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 6855,
      "label": "cervical carcinoma"
    }
  ]
}