{
  "id": 7711,
  "label": "colon Burkitt lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006150",
  "properties": {
    "xrefs": [
      "GARD:0024311",
      "MEDGEN:272491",
      "NCIT:C27465",
      "UMLS:C1333083"
    ],
    "synonyms": [
      "Burkitt lymphoma of colon",
      "Burkitts lymphoma of colon",
      "colon Burkitt lymphoma",
      "colon Burkitt's lymphoma",
      "colon Burkitts lymphoma",
      "primary colon Burkitt's lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare Burkitt lymphoma that arises from the colon."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3028,
      "label": "immune system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060083"
        ],
        "synonyms": [
          "cancer of immune system",
          "immune system cancer",
          "malignant immune system neoplasm",
          "malignant neoplasm of immune system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the immune system"
      },
      "child_count": 50,
      "reference_id": "MONDO:0000621"
    },
    {
      "id": 4182,
      "label": "colon lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20304,
        21564
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1523",
          "GARD:0023059",
          "ICD9:202.80",
          "MEDGEN:101033",
          "NCIT:C4793",
          "SCTID:133751000119102",
          "UMLS:C0519037"
        ],
        "synonyms": [
          "colon lymphoma",
          "colonic lymphoma",
          "lymphoma of colon",
          "lymphoma of the colon",
          "primary colon lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An extranodal lymphoma that arises from the colon. The majority are B-cell non-Hodgkin lymphomas."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002035"
    },
    {
      "id": 8648,
      "label": "Burkitt lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6694,
        17660,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8584",
          "EFO:0000309",
          "GARD:0005973",
          "ICD10CM:C83.7",
          "ICD9:200.2",
          "ICDO:9687/3",
          "MEDGEN:2377",
          "MESH:D002051",
          "MedDRA:10006595",
          "MedDRA:10053518",
          "MedDRA:10067184",
          "NCIT:C2912",
          "OMIM:113970",
          "ONCOTREE:BL",
          "Orphanet:543",
          "SCTID:118617000",
          "UMLS:C0006413",
          "icd11.foundation:2100138081"
        ],
        "synonyms": [
          "Burkitt lymphoma",
          "Burkitt lymphoma/leukemia",
          "Burkitt's lymphoma",
          "Burkitt's tumour",
          "Burkitt's tumour or lymphoma",
          "burkitt lymphoma, somatic",
          "small non-cleaved cell lymphoma",
          "small non-cleaved cell lymphoma, Burkitt's type",
          "BL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare form of malignant mature B-cell non-Hodgkin lymphoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0007243"
    },
    {
      "id": 21140,
      "label": "familial colorectal cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7221
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008533"
        ],
        "synonyms": [
          "hereditary colorectal cancer",
          "colorectal cancer, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered 'hereditary' and is thought to be caused by an inherited predisposition tocolon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes (mutations) in the APC , MYH , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM , PTEN , STK11 , SMAD4 , BMPR1A , NTHL1 , POLE , and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories."
      },
      "child_count": 8,
      "reference_id": "MONDO:0023113"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3028,
      "label": "immune system cancer"
    },
    {
      "id": 4182,
      "label": "colon lymphoma"
    },
    {
      "id": 8648,
      "label": "Burkitt lymphoma"
    },
    {
      "id": 21140,
      "label": "familial colorectal cancer"
    }
  ]
}