{
  "id": 7726,
  "label": "colorectal squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006165",
  "properties": {
    "xrefs": [
      "EFO:1000198",
      "MEDGEN:317527",
      "NCIT:C43588",
      "UMLS:C1707442"
    ],
    "synonyms": [
      "colorectal (colon or rectal) squamous cell cancer",
      "colorectal squamous cell cancer",
      "colorectal squamous cell carcinoma",
      "colorectum squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A very rare colorectal carcinoma characterized by the presence of a malignant squamous cell infiltrate."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 21360,
      "label": "colorectal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7221,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080199",
          "EFO:1001951",
          "MEDGEN:3170",
          "NCIT:C2955",
          "UMLS:C0009402"
        ],
        "synonyms": [
          "cancer of large bowel",
          "cancer of large intestine",
          "cancer of the large bowel",
          "cancer of the large intestine",
          "colorectal (colon or rectal) cancer",
          "colorectal cancer",
          "large bowel cancer",
          "large intestine cancer",
          "CRC",
          "carcinoma of colorectum",
          "carcinoma of large bowel",
          "carcinoma of large intestine",
          "carcinoma of the large bowel",
          "carcinoma of the large intestine",
          "colorectal carcinoma",
          "colorectum carcinoma",
          "large bowel carcinoma",
          "large intestine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024331"
    }
  ],
  "children": [
    {
      "id": 7718,
      "label": "colorectal adenosquamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7652,
        7726
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000190",
          "MEDGEN:317524",
          "NCIT:C43589",
          "UMLS:C1707437"
        ],
        "synonyms": [
          "colorectal (colon or rectal) adenosquamous cancer",
          "colorectal adenosquamous cancer",
          "colorectal adenosquamous carcinoma",
          "colorectum adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An unusual colorectal carcinoma characterized by the presence of glandular and squamous carcinomatous components. The two carcinomatous components may be admixed within the tumor, or the two may appear separately in different areas."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006157"
    },
    {
      "id": 18544,
      "label": "squamous cell carcinoma of colon",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4179,
        7726
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5519",
          "GARD:0021768",
          "MEDGEN:272494",
          "NCIT:C5490",
          "Orphanet:423994",
          "SCTID:766981007",
          "UMLS:C1333100"
        ],
        "synonyms": [
          "colon epidermoid carcinoma",
          "colon squamous cell cancer",
          "colon squamous cell carcinoma",
          "colonic epidermoid carcinoma",
          "colonic squamous cell carcinoma",
          "epidermoid carcinoma of colon",
          "epidermoid carcinoma of the colon",
          "squamous cell carcinoma of colon",
          "squamous cell carcinoma of the colon",
          "squamous cell colon carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the colon."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018513"
    },
    {
      "id": 18545,
      "label": "squamous cell carcinoma of rectum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7726,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5528",
          "GARD:0021770",
          "MEDGEN:235534",
          "NCIT:C5554",
          "Orphanet:424002",
          "SCTID:766979005",
          "UMLS:C1335690"
        ],
        "synonyms": [
          "rectal squamous carcinoma",
          "rectal squamous cell cancer",
          "rectal squamous cell carcinoma",
          "rectum squamous cell carcinoma",
          "squamous carcinoma of rectum",
          "squamous carcinoma of the rectum",
          "squamous cell carcinoma of rectum",
          "squamous cell carcinoma of the rectum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A very rare rectal carcinoma characterized by the presence of a malignant squamous cell infiltrate."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018515"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 21360,
      "label": "colorectal carcinoma"
    }
  ]
}