{
  "id": 7728,
  "label": "combined lung carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006167",
  "properties": {
    "xrefs": [
      "EFO:1000200",
      "GARD:0024316",
      "MEDGEN:234166",
      "NCIT:C7591",
      "UMLS:C1333123"
    ],
    "synonyms": [
      "combined carcinoma of lung",
      "combined carcinoma of the lung",
      "combined lung cancer",
      "combined lung carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A lung carcinoma characterized by the presence of large or small neuroendocrine carcinoma cells in combination with malignant glandular or squamous epithelial cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 6862,
      "label": "lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        10167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3905",
          "EFO:0001071",
          "MEDGEN:195765",
          "NCIT:C4878",
          "UMLS:C0684249",
          "icd11.foundation:947165291"
        ],
        "synonyms": [
          "cancer of lung",
          "cancer of the lung",
          "lung cancer",
          "lung cancer, NOS",
          "carcinoma of lung",
          "carcinoma of the lung",
          "lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the lung"
      },
      "child_count": 20,
      "reference_id": "MONDO:0005138"
    },
    {
      "id": 7117,
      "label": "lung neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19314,
        20356
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5410",
          "EFO:0005220",
          "GARD:0024190",
          "ICD9:209.61",
          "MEDGEN:277303",
          "NCIT:C5670",
          "ONCOTREE:LNET",
          "SCTID:707594002",
          "UMLS:C1334452"
        ],
        "synonyms": [
          "lung NET",
          "lung neuroendocrine neoplasm",
          "lung neuroendocrine tumor",
          "lung neuroendocrine tumor, well differentiated, low or intermediate grade",
          "lung neuroendocrine tumour",
          "neuroendocrine neoplasm of lung",
          "neuroendocrine neoplasm of the lung",
          "pulmonary neuroendocrine neoplasm",
          "pulmonary neuroendocrine tumor",
          "pulmonary neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A low, intermediate, or high grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005454"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20288
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:154",
          "EFO:1000356",
          "ICDO:8940/3",
          "MEDGEN:64618",
          "MESH:D018198",
          "NCIT:C3729",
          "UMLS:C0206625"
        ],
        "synonyms": [
          "mixed cell type cancer",
          "mixed neoplasm",
          "mixed tumor",
          "mixed tumour",
          "malignant mixed neoplasm",
          "malignant mixed tumor",
          "malignant mixed tumour",
          "mixed neoplasm, malignant",
          "mixed tumor, malignant (morphologic abnormality)",
          "mixed tumor, malignant, NOS (morphologic abnormality)",
          "tumor, mixed, malignant",
          "malignant mixed tumors",
          "malignant mixed tumours",
          "mixed tumors, malignant",
          "tumor, malignant mixed",
          "tumors, malignant mixed"
        ],
        "definition": "A malignant neoplasm composed of a carcinomatous epithelial component and a sarcomatous mesenchymal component. Representative examples include malignant mixed mesodermal (Mullerian) tumor of the female reproductive system and carcinosarcoma of the salivary gland and the lung."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005853"
    }
  ],
  "children": [
    {
      "id": 5365,
      "label": "combined small cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7728,
        9726
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5421",
          "GARD:0023510",
          "ICDO:8045/3",
          "MEDGEN:234167",
          "NCIT:C9137",
          "ONCOTREE:CSCLC",
          "UMLS:C1333125",
          "icd11.foundation:392248394"
        ],
        "synonyms": [
          "combined small and large cell lung cancer",
          "combined small and large cell lung carcinoma",
          "combined small cell and large cell lung carcinoma",
          "combined small cell carcinoma of lung",
          "combined small cell carcinoma of the lung",
          "combined small cell lung cancer",
          "combined small cell lung carcinoma",
          "combined type small cell carcinoma of lung",
          "combined type small cell carcinoma of the lung",
          "combined type small cell lung carcinoma",
          "mixed small cell and large cell carcinoma of lung",
          "mixed small cell and large cell carcinoma of the lung",
          "mixed small cell and large cell lung carcinoma",
          "small cell and large cell carcinoma of lung",
          "small cell and large cell carcinoma of the lung",
          "small cell and large cell lung carcinoma",
          "CSCLC",
          "lung combined type small cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of small cell lung carcinoma in combination with a non-small cell carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003438"
    },
    {
      "id": 5969,
      "label": "lung combined large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5818,
        7728
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7207",
          "GARD:0023843",
          "MEDGEN:232386",
          "NCIT:C7267",
          "UMLS:C1333122"
        ],
        "synonyms": [
          "combined large cell lung neuroendocrine carcinoma",
          "combined large cell neuroendocrine carcinoma of lung",
          "combined large cell neuroendocrine carcinoma of the lung",
          "pulmonary combined large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A subtype of large cell neuroendocrine lung carcinoma characterized by the presence of large neuroendocrine cells in combination with adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/ or spindle cell carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004142"
    }
  ],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 6862,
      "label": "lung carcinoma"
    },
    {
      "id": 7117,
      "label": "lung neuroendocrine neoplasm"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm"
    }
  ]
}