{ "id": 7738, "label": "digestive system carcinoma", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0006181", "properties": { "xrefs": [ "DOID:0050922", "EFO:1000218", "HP:0002672", "MEDGEN:57467", "NCIT:C96963", "UMLS:C0151544" ], "synonyms": [ "carcinoma of digestive system", "carcinoma of the gastrointestinal system", "digestive system carcinoma", "gastrointestinal carcinoma", "gastrointestinal carcinoma (disease)", "gastrointestinal system carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma." }, "isLeaf": false, "isRoot": false, "child_count": 16, "parents": [ { "id": 4587, "label": "digestive system cancer", "isLeaf": false, "isRoot": false, "parents": [ 6151, 6733, 20434 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3119", "ICD10CM:C15-C26", "ICD9:239.0", "MEDGEN:148231", "NCIT:C4890", "UMLS:C0751075" ], "synonyms": [ "GI tumor", "GI tumour", "cancer of digestive system", "digestive system cancer", "gastrointestinal system cancer", "malignant digestive system neoplasm", "malignant gastrointestinal neoplasm", "malignant gastrointestinal system neoplasm", "malignant neoplasm of digestive system" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving any part of the digestive system." }, "child_count": 45, "reference_id": "MONDO:0002516" }, { "id": 6734, "label": "carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7265 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-1867", "DOID:305", "EFO:0000313", "ICDO:8010/3", "ICDO:8011/3", "MEDGEN:2867", "MESH:D002277", "NCIT:C2916", "SCTID:722688002", "UMLS:C0007097" ], "synonyms": [ "epithelioma", "Other carcinoma", "carcinoma", "carcinoma, malignant", "epithelial carcinoma", "epithelioma malignant", "malignant epithelial neoplasm", "malignant epithelial tumor", "malignant epithelial tumour", "malignant epithelioma" ], "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas." }, "child_count": 98, "reference_id": "MONDO:0004993" } ], "children": [ { "id": 3934, "label": "maxillary sinus carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 2879, 4264, 7738, 8294 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1357", "GARD:0023002", "ICD9:160.2", "MEDGEN:196632", "NCIT:C3540", "NCIT:C9332", "SCTID:363425008", "UMLS:C0740487" ], "synonyms": [ "cancer of maxillary sinus", "carcinoma of maxillary sinus", "malignant maxillary sinus neoplasm", "malignant maxillary sinus tumor", "malignant maxillary sinus tumour", "malignant neoplasm of maxillary sinus", "malignant neoplasm of the maxillary sinus", "malignant tumor of maxillary sinus", "malignant tumor of the maxillary sinus", "malignant tumour of maxillary sinus", "malignant tumour of the maxillary sinus", "maxillary sinus cancer", "maxillary sinus carcinoma" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0003900", "name": "connective tissue disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A carcinoma that arises from the maxillary sinus. Representative examples include squamous cell carcinoma, adenocarcinoma, and adenoid cystic carcinoma." }, "child_count": 12, "reference_id": "MONDO:0001748" }, { "id": 5173, "label": "gastroesophageal junction adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712, 7738 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4944", "MEDGEN:231030", "NCIT:C9296", "ONCOTREE:EGC", "ONCOTREE:GEJ", "UMLS:C1332166" ], "synonyms": [ "adenocarcinoma - GEJ", "adenocarcinoma of cardioesophageal junction", "adenocarcinoma of gastroesophageal junction", "adenocarcinoma of the EG junction", "adenocarcinoma of the GE junction", "adenocarcinoma of the cardioesophageal junction", "adenocarcinoma of the esophagogastric junction", "adenocarcinoma of the gastroesophageal junction", "esophagogastric junction adenocarcinoma", "gastroesophageal junction adenocarcinoma", "esophagogastric adenocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the esophagogastric junction." }, "child_count": 0, "reference_id": "MONDO:0003219" }, { "id": 5174, "label": "gallbladder carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 7085, 7738 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4948", "EFO:1001956", "GARD:0023412", "MEDGEN:116001", "NCIT:C3844", "SCTID:372140005", "UMLS:C0235782" ], "synonyms": [ "gallbladder cancer", "Gall bladder carcinoma (adeno)", "Gall bladder carcinoma (adenocarcinoma)", "cancer of gallbladder", "cancer of the gallbladder", "carcinoma of gall bladder", "carcinoma of gallbladder", "carcinoma of the gallbladder", "gall bladder carcinoma", "gallbladder carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the gall bladder" }, "child_count": 10, "reference_id": "MONDO:0003220" }, { "id": 6478, "label": "intestine carcinoma in situ", "isLeaf": false, "isRoot": false, "parents": [ 6433, 7430, 7738 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9024", "ICD9:230.7", "MEDGEN:672856", "SCTID:92617001", "UMLS:C0685941" ], "synonyms": [ "carcinoma in situ of intestine", "intestine in situ carcinoma", "stage 0 intestine carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma in situ involving a intestine." }, "child_count": 6, "reference_id": "MONDO:0004698" }, { "id": 6695, "label": "gastric carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 3312, 7738 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10538", "DOID:5517", "EFO:0000178", "GARD:0027710", "ICD9:151.3", "MEDGEN:147066", "NCIT:C4911", "SCTID:187741001", "UMLS:C0699791", "icd11.foundation:1503707183" ], "synonyms": [ "cancer of stomach", "cancer of the stomach", "gastric (stomach) cancer", "gastric cancer", "gastric cancer, NOS", "stomach cancer", "carcinoma of stomach", "carcinoma of the stomach", "gastric carcinoma", "stomach carcinoma", "Ca fundus - stomach", "cancer of fundus of stomach", "fundus of stomach cancer", "gastric fundus cancer", "malignant fundus of stomach neoplasm", "malignant neoplasm of fundus of stomach", "malignant tumor of fundus of stomach", "malignant tumour of fundus of stomach" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the stomach." }, "child_count": 24, "reference_id": "MONDO:0004950" }, { "id": 6912, "label": "exocrine pancreatic carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4251, 7738 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4905", "EFO:0002618", "GARD:0027717", "MEDGEN:65917", "NCIT:C3850", "SCTID:372142002", "UMLS:C0235974" ], "synonyms": [ "cancer of pancreas", "cancer of the pancreas", "exocrine cancer", "pancreas cancer", "pancreatic cancer", "carcinoma of exocrine pancreas", "carcinoma of the pancreas", "exocrine pancreas carcinoma", "pancreas carcinoma", "pancreatic cancer (not islets)", "pancreatic carcinoma, familial" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the exocrine pancreas" }, "child_count": 16, "reference_id": "MONDO:0005192" }, { "id": 7176, "label": "small intestine carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 3225, 7738 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4907", "EFO:0005588", "GARD:0024201", "MEDGEN:65952", "NCIT:C7724", "ONCOTREE:SIC", "SCTID:448664009", "UMLS:C0238196", "icd11.foundation:1484520499" ], "synonyms": [ "cancer of small bowel", "cancer of the small bowel", "small bowel cancer", "small intestinal cancer", "small intestine cancer", "carcinoma of small bowel", "carcinoma of small intestine", "carcinoma of the small bowel", "carcinoma of the small intestine", "small bowel carcinoma", "small intestinal carcinoma", "small intestine cancer, NOS", "small intestine carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the small intestine" }, "child_count": 6, "reference_id": "MONDO:0005522" }, { "id": 7497, "label": "pancreatic endocrine carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4255, 7431, 7738, 11035 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1798", "EFO:0007416", "GARD:0022056", "ICD10CM:C25.4", "ICD9:157.4", "ICDO:8150/3", "MEDGEN:233070", "MESH:D018273", "NCIT:C3770", "Orphanet:506098", "SCTID:254612002", "UMLS:C1328479" ], "synonyms": [ "Pancreatic Neuroendocrine cancer", "carcinoma of endocrine pancreas", "carcinoma, islet cell, malignant", "endocrine pancreas carcinoma", "high grade pancreatic neuroendocrine carcinoma", "high-grade pancreatic neuroendocrine carcinoma", "islet cell cancer", "islet cell carcinoma", "islet cell carcinoma (morphologic abnormality)", "malignant islet cell tumor", "malignant islet cell tumour", "malignant neoplasm of islets of Langerhans", "malignant pancreatic endocrine tumor", "malignant pancreatic endocrine tumour", "pancreatic NEC", "pancreatic NEC G3", "pancreatic endocrine cancer", "pancreatic endocrine carcinoma", "pancreatic neuroendocrine carcinoma", "poorly differentiated pancreatic endocrine carcinoma", "poorly-differentiated NEN of pancreas", "poorly-differentiated neuroendocrine neoplasm of pancreas", "poorly-differentiated pancreatic NEN", "poorly-differentiated pancreatic neuroendocrine neoplasm", "neuroendocrine carcinoma of pancreas" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma." }, "child_count": 8, "reference_id": "MONDO:0005893" }, { "id": 7657, "label": "ameloblastic carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 3041, 4185, 7738, 20417 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000078", "GARD:0011855", "MEDGEN:231088", "NCIT:C7492", "NORD:763", "Orphanet:314422", "UMLS:C1314678" ], "synonyms": [ "ameloblastic carcinoma", "odontoma, ameloblastic, malignant" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A rare, cytologically malignant ameloblastoma that may metastasize." }, "child_count": 0, "reference_id": "MONDO:0006079" }, { "id": 7739, "label": "digestive system mixed adenoneuroendocrine carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 7738 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000219", "ICDO:8244/3", "MEDGEN:459355", "NCIT:C95406", "UMLS:C2987129" ], "synonyms": [ "MANEC", "digestive system Mixed Adenoneuroendocrine cancer", "digestive system mixed adenoneuroendocrine carcinoma", "gastrointestinal MANEC", "gastrointestinal mixed Adenoneuroendocrine carcinoma", "mixed Adenoneuroendocrine carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from the digestive system and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30% of either component should be present for the diagnosis to be made." }, "child_count": 1, "reference_id": "MONDO:0006182" }, { "id": 18551, "label": "carcinoma of liver and intrahepatic biliary tract", "isLeaf": false, "isRoot": false, "parents": [ 4735, 7738 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0021786", "MEDGEN:78921", "NCIT:C7927", "ONCOTREE:HCCIHCH", "Orphanet:424936", "UMLS:C0279000" ], "synonyms": [ "cancer of liver", "cancer of liver and intrahepatic biliary tract", "cancer of the liver", "cancer of the liver and intrahepatic biliary tract", "carcinoma of liver", "hepatic cancer", "liver and intrahepatic bile duct cancer", "liver cancer", "liver carcinoma", "liver/hepatobiliary cancer", "carcinoma of liver and IBT", "liver and intrahepatic bile duct carcinoma", "liver and intrahepatic biliary tract cancer", "liver and intrahepatic biliary tract carcinoma", "primary liver carcinoma", "hepatocellular carcinoma plus intrahepatic cholangiocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma." }, "child_count": 14, "reference_id": "MONDO:0018531" }, { "id": 18977, "label": "carcinoma of esophagus", "isLeaf": false, "isRoot": false, "parents": [ 7738, 8953 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1107", "EFO:0002916", "GARD:0006383", "MEDGEN:56256", "MedDRA:10030155", "NCIT:C3513", "Orphanet:70482", "SCTID:372138000", "UMLS:C0152018" ], "synonyms": [ "Esophageal cancer", "carcinoma of esophagus", "carcinoma of the esophagus", "carcinoma of the oesophagus", "esophageal carcinoma", "esophagus carcinoma", "oesophagus carcinoma", "cancer of esophagus", "cancer of oesophagus", "cancer of the esophagus", "cancer of the oesophagus", "esophageal cancer", "esophageal cancer, NOS" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)." }, "child_count": 10, "reference_id": "MONDO:0019086" }, { "id": 20515, "label": "carcinoma of floor of mouth", "isLeaf": false, "isRoot": false, "parents": [ 4185, 7738, 20499 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:756825", "NCIT:C9319", "SCTID:449156009", "UMLS:C3164417" ], "synonyms": [ "mouth floor cancer", "carcinoma of mouth floor", "carcinoma of the floor of the mouth", "floor of mouth carcinoma", "floor of the mouth carcinoma", "mouth floor carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma that involves the mouth floor." }, "child_count": 6, "reference_id": "MONDO:0021343" }, { "id": 20516, "label": "carcinoma of pharynx", "isLeaf": false, "isRoot": false, "parents": [ 7738, 20455 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:757152", "NCIT:C9466", "SCTID:449254004", "UMLS:C3164746" ], "synonyms": [ "cancer of the pharynx", "carcinoma of pharynx", "carcinoma of the pharynx", "pharyngeal carcinoma", "pharyngeal throat cancer", "pharynx carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that involves the pharynx." }, "child_count": 12, "reference_id": "MONDO:0021345" }, { "id": 21360, "label": "colorectal carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 7221, 7738 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080199", "EFO:1001951", "MEDGEN:3170", "NCIT:C2955", "UMLS:C0009402" ], "synonyms": [ "cancer of large bowel", "cancer of large intestine", "cancer of the large bowel", "cancer of the large intestine", "colorectal (colon or rectal) cancer", "colorectal cancer", "large bowel cancer", "large intestine cancer", "CRC", "carcinoma of colorectum", "carcinoma of large bowel", "carcinoma of large intestine", "carcinoma of the large bowel", "carcinoma of the large intestine", "colorectal carcinoma", "colorectum carcinoma", "large bowel carcinoma", "large intestine carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas." }, "child_count": 8, "reference_id": "MONDO:0024331" }, { "id": 23483, "label": "oral cavity carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 7170, 7738, 21254 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0027982", "MEDGEN:57468", "NCIT:C8990", "UMLS:C0151546" ], "synonyms": [ "oral cavity cancer", "carcinoma of mouth", "carcinoma of oral cavity", "carcinoma of the oral cavity", "mouth carcinoma", "oral cavity carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma." }, "child_count": 27, "reference_id": "MONDO:0044925" } ], "roots": [ { "id": 4587, "label": "digestive system cancer" }, { "id": 6734, "label": "carcinoma" } ] }