{
  "id": 7758,
  "label": "extrahepatic bile duct squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006203",
  "properties": {
    "xrefs": [
      "EFO:1000248",
      "GARD:0024328",
      "NCIT:C5777"
    ],
    "synonyms": [
      "bile duct squamous cell carcinoma",
      "squamous cell bile duct carcinoma",
      "squamous cell carcinoma of bile duct",
      "squamous cell carcinoma of the bile duct",
      "extrahepatic bile duct squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the extrahepatic bile ducts. It is composed entirely by malignant squamous epithelial cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5076,
      "label": "extrahepatic bile duct carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7152,
        20500
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4682",
          "GARD:0023363",
          "MEDGEN:116036",
          "NCIT:C3860",
          "SCTID:372101000",
          "UMLS:C0238019"
        ],
        "synonyms": [
          "carcinoma of extrahepatic bile duct",
          "carcinoma of the extrahepatic bile duct",
          "extrahepatic bile duct cancer",
          "extrahepatic bile duct carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the extrahepatic bile duct."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003090"
    },
    {
      "id": 5414,
      "label": "squamous cell bile duct carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7152,
        18553
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5537",
          "GARD:0023530",
          "MEDGEN:209017",
          "UMLS:C0861861"
        ],
        "synonyms": [
          "bile duct squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the bile duct."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003500"
    }
  ],
  "children": [
    {
      "id": 5407,
      "label": "ampulla of vater squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7758,
        17870,
        18541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5527",
          "GARD:0023526",
          "MEDGEN:272304",
          "NCIT:C27417",
          "UMLS:C1332251"
        ],
        "synonyms": [
          "ampulla of Vater squamous cell carcinoma",
          "hepatopancreatic ampulla squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma with squamous differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003490"
    },
    {
      "id": 7757,
      "label": "extrahepatic bile duct adenosquamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5453,
        7758
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000247",
          "GARD:0024327",
          "NCIT:C5778"
        ],
        "synonyms": [
          "extrahepatic bile duct adenosquamous carcinoma",
          "adenosquamous bile duct carcinoma",
          "adenosquamous carcinoma of bile duct",
          "adenosquamous carcinoma of the bile duct",
          "bile duct adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of glandular and squamous malignant epithelial components."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006202"
    },
    {
      "id": 18556,
      "label": "squamous cell carcinoma of gallbladder and extrahepatic biliary tract",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7758,
        18842
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021792",
          "MEDGEN:1635098",
          "Orphanet:424996",
          "SCTID:766978002",
          "UMLS:C4707898"
        ],
        "synonyms": [
          "squamous cell carcinoma of gallblader and EBT"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Squamous cell carcinoma of the gallbladder and extrahepatic biliary tract is a rare hepatic and biliary tract tumor, arising either in the gallbladder itself or in the epithelium lining the extrahepatic biliary tree, the cystic duct and peribiliary glands. It is characterized by a substantial keratinization with abundant keratohyalin pearls and central deposition of dense keratin material within infiltrative nests and locally aggressive nature. In the early stages of the disease symptoms are vague and nonspecific (abdominal pain, jaundice and vomiting). In the advanced stages it may present with a bulky tumor and symptoms of adjacent organ involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018537"
    }
  ],
  "roots": [
    {
      "id": 5076,
      "label": "extrahepatic bile duct carcinoma"
    },
    {
      "id": 5414,
      "label": "squamous cell bile duct carcinoma"
    }
  ]
}