{
  "id": 7763,
  "label": "fibrolamellar hepatocellular carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006210",
  "properties": {
    "xrefs": [
      "DOID:5015",
      "EFO:1000256",
      "GARD:0021704",
      "ICDO:8171/3",
      "MEDGEN:83122",
      "MESH:C537258",
      "NCIT:C4131",
      "ONCOTREE:FLC",
      "Orphanet:401920",
      "SCTID:253018005",
      "UMLS:C0334287"
    ],
    "synonyms": [
      "FHCC",
      "FLC",
      "fibrolamellar cancer",
      "fibrolamellar carcinoma",
      "fibrolamellar carcinoma of liver cells",
      "fibrolamellar carcinoma of the liver cells",
      "fibrolamellar hepatocarcinoma",
      "fibrolamellar hepatocellular carcinoma",
      "hepatocellular carcinoma, fibrolamellar",
      "hepatocellular fibrolamellar carcinoma",
      "liver cell fibrolamellar carcinoma",
      "oncocytic hepatocellular tumor",
      "oncocytic hepatocellular tumour",
      "polygonal cell type hepatocellular carcinoma with fibrous Stroma",
      "FL-HCC",
      "eosinophilic glassy cell hepatoma",
      "eosinophilic hepatocellular carcinoma with lamellar fibrosis",
      "fibrolamellar oncocytic hepatoma",
      "fibrolamellar variant of hepatocellular carcinoma",
      "hepatocellular carcinoma (fibrolamellar variant)",
      "hepatocellular carcinoma with increased stromal fibrosis",
      "polygonal cell hepatocellular carcinoma with fibrous stroma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A distinctive type of liver cell carcinoma that arises in non-cirrhotic livers and is seen predominantly in young patients. The tumor cells are polygonal and deeply eosinophilic, and are embedded in a fibrous stroma. The prognosis is similar to classical hepatocellular carcinoma that arises in non-cirrhotic livers, and better than hepatocellular carcinoma that arises in cirrhotic livers."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 8660,
      "label": "hepatocellular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:684",
          "DOID:686",
          "EFO:0000182",
          "GARD:0016773",
          "ICD10CM:C22.0",
          "ICDO:8170/3",
          "MEDGEN:389187",
          "MESH:D006528",
          "MedDRA:10049010",
          "NANDO:2200047",
          "NCIT:C3099",
          "NORD:1907",
          "OMIM:114550",
          "ONCOTREE:HCC",
          "Orphanet:88673",
          "UMLS:C2239176",
          "icd11.foundation:1294035808"
        ],
        "synonyms": [
          "HCC",
          "cancer, hepatocellular",
          "carcinoma of liver",
          "carcinoma of liver cells",
          "carcinoma of the liver cells",
          "carcinoma, hepatocellular, malignant",
          "hepatoblastoma, somatic",
          "hepatocellular adenocarcinoma",
          "hepatocellular cancer",
          "hepatocellular cancer, somatic",
          "hepatocellular carcinoma",
          "hepatocellular carcinoma, childhood type, somatic",
          "hepatocellular carcinoma, somatic",
          "hepatoma",
          "liver carcinoma",
          "liver cell cancer (hepatocellular carcinoma)",
          "liver cell carcinoma",
          "primary carcinoma of liver cells",
          "primary carcinoma of the liver cells",
          "adult hepatoma",
          "adult primary hepatocellular carcinoma",
          "hepatoblastoma",
          "hepatoblastoma caused by somatic mutation",
          "liver and intrahepatic bile duct carcinoma",
          "liver cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation."
      },
      "child_count": 16,
      "reference_id": "MONDO:0007256"
    }
  ],
  "children": [
    {
      "id": 3171,
      "label": "mixed fibrolamellar hepatocellular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080182",
          "GARD:0022839"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A fibrolamellar carcinoma that is characterized by the presence of both pure fibrolamellar hepatocellular carcinoma and and conventional hepatocellular carcinoma components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000891"
    }
  ],
  "roots": [
    {
      "id": 8660,
      "label": "hepatocellular carcinoma"
    }
  ]
}